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Gene: PTPRG |
Gene summary for PTPRG |
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Gene information | Species | Human | Gene symbol | PTPRG | Gene ID | 5793 |
Gene name | protein tyrosine phosphatase receptor type G | |
Gene Alias | HPTPG | |
Cytomap | 3p14.2 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | P23470 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5793 | PTPRG | CCI_1 | Human | Cervix | CC | 2.73e-09 | 1.54e+00 | 0.528 |
5793 | PTPRG | CCI_2 | Human | Cervix | CC | 7.17e-03 | 5.95e-02 | 0.5249 |
5793 | PTPRG | HTA11_347_2000001011 | Human | Colorectum | AD | 2.21e-04 | 4.75e-01 | -0.1954 |
5793 | PTPRG | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.20e-10 | 1.01e+00 | -0.059 |
5793 | PTPRG | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.90e-07 | -5.79e-01 | -0.2061 |
5793 | PTPRG | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.45e-05 | 6.13e-01 | 0.0446 |
5793 | PTPRG | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.69e-04 | -5.67e-01 | 0.0451 |
5793 | PTPRG | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.09e-06 | 5.68e-01 | 0.294 |
5793 | PTPRG | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.84e-27 | 1.41e+00 | 0.3487 |
5793 | PTPRG | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.64e-23 | 1.42e+00 | 0.281 |
5793 | PTPRG | A002-C-010 | Human | Colorectum | FAP | 1.18e-10 | 1.94e-01 | 0.242 |
5793 | PTPRG | A001-C-207 | Human | Colorectum | FAP | 7.38e-03 | 6.20e-02 | 0.1278 |
5793 | PTPRG | A015-C-203 | Human | Colorectum | FAP | 6.28e-38 | -5.88e-01 | -0.1294 |
5793 | PTPRG | A015-C-204 | Human | Colorectum | FAP | 4.24e-05 | -2.66e-01 | -0.0228 |
5793 | PTPRG | A014-C-040 | Human | Colorectum | FAP | 6.84e-03 | -3.22e-01 | -0.1184 |
5793 | PTPRG | A002-C-201 | Human | Colorectum | FAP | 5.35e-13 | -2.67e-01 | 0.0324 |
5793 | PTPRG | A001-C-119 | Human | Colorectum | FAP | 1.65e-13 | -6.36e-01 | -0.1557 |
5793 | PTPRG | A001-C-108 | Human | Colorectum | FAP | 1.81e-19 | -4.67e-01 | -0.0272 |
5793 | PTPRG | A002-C-205 | Human | Colorectum | FAP | 6.31e-30 | -6.61e-01 | -0.1236 |
5793 | PTPRG | A001-C-104 | Human | Colorectum | FAP | 2.54e-02 | -2.10e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:20001463 | Cervix | CC | negative regulation of cell motility | 71/2311 | 359/18723 | 3.47e-05 | 5.60e-04 | 71 |
GO:00303363 | Cervix | CC | negative regulation of cell migration | 68/2311 | 344/18723 | 5.11e-05 | 7.70e-04 | 68 |
GO:00313456 | Cervix | CC | negative regulation of cell projection organization | 39/2311 | 186/18723 | 5.86e-04 | 5.57e-03 | 39 |
GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
GO:00109775 | Cervix | CC | negative regulation of neuron projection development | 28/2311 | 137/18723 | 4.74e-03 | 2.83e-02 | 28 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTPRG | SNV | Missense_Mutation | novel | c.2876N>A | p.Arg959Gln | p.R959Q | P23470 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-71-6725-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PTPRG | SNV | Missense_Mutation | c.2515G>A | p.Glu839Lys | p.E839K | P23470 | protein_coding | deleterious(0.01) | possibly_damaging(0.807) | TCGA-78-7154-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PTPRG | SNV | Missense_Mutation | novel | c.677N>G | p.His226Arg | p.H226R | P23470 | protein_coding | tolerated(1) | probably_damaging(0.998) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRG | SNV | Missense_Mutation | c.2119N>C | p.Phe707Leu | p.F707L | P23470 | protein_coding | tolerated(0.49) | benign(0) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
PTPRG | SNV | Missense_Mutation | c.354A>C | p.Lys118Asn | p.K118N | P23470 | protein_coding | deleterious(0.04) | possibly_damaging(0.575) | TCGA-18-5592-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PTPRG | SNV | Missense_Mutation | c.2791N>G | p.Thr931Ala | p.T931A | P23470 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTPRG | SNV | Missense_Mutation | novel | c.190N>T | p.Gly64Cys | p.G64C | P23470 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-34-2600-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRG | SNV | Missense_Mutation | c.2241N>T | p.Leu747Phe | p.L747F | P23470 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD | |
PTPRG | SNV | Missense_Mutation | novel | c.3833N>T | p.Thr1278Ile | p.T1278I | P23470 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-68-7755-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unspecific | SD | |
PTPRG | SNV | Missense_Mutation | novel | c.3769N>A | p.Glu1257Lys | p.E1257K | P23470 | protein_coding | deleterious(0.03) | benign(0.168) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5793 | PTPRG | PROTEIN PHOSPHATASE, DRUGGABLE GENOME | inhibitor | 252827488 |
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