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Gene: PRG4 |
Gene summary for PRG4 |
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Gene information | Species | Human | Gene symbol | PRG4 | Gene ID | 10216 |
Gene name | proteoglycan 4 | |
Gene Alias | CACP | |
Cytomap | 1q31.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q92954 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10216 | PRG4 | NAFLD1 | Human | Liver | NAFLD | 1.53e-03 | 3.30e-01 | -0.04 |
10216 | PRG4 | HCC1_Meng | Human | Liver | HCC | 2.67e-79 | 3.04e-01 | 0.0246 |
10216 | PRG4 | cirrhotic3 | Human | Liver | Cirrhotic | 7.74e-05 | 3.34e-01 | 0.0215 |
10216 | PRG4 | HCC2 | Human | Liver | HCC | 2.81e-72 | 6.87e+00 | 0.5341 |
10216 | PRG4 | Pt14.a | Human | Liver | HCC | 1.26e-06 | 2.67e-01 | 0.0169 |
10216 | PRG4 | S027 | Human | Liver | HCC | 3.63e-08 | 6.89e-01 | 0.2446 |
10216 | PRG4 | S028 | Human | Liver | HCC | 2.91e-25 | 1.00e+00 | 0.2503 |
10216 | PRG4 | S029 | Human | Liver | HCC | 1.79e-27 | 1.13e+00 | 0.2581 |
10216 | PRG4 | HTA12-23-1 | Human | Pancreas | PDAC | 8.83e-07 | 6.58e-01 | 0.3405 |
10216 | PRG4 | HTA12-25-1 | Human | Pancreas | PDAC | 3.56e-02 | 3.28e-01 | 0.313 |
10216 | PRG4 | HTA12-26-1 | Human | Pancreas | PDAC | 1.03e-14 | 7.48e-01 | 0.3728 |
10216 | PRG4 | HTA12-29-1 | Human | Pancreas | PDAC | 1.08e-04 | 1.96e-01 | 0.3722 |
10216 | PRG4 | HTA12-30-1 | Human | Pancreas | PDAC | 1.14e-02 | 8.14e-01 | 0.3671 |
10216 | PRG4 | HTA12-9-1 | Human | Pancreas | PDAC | 4.42e-05 | 4.11e-01 | 0.1532 |
10216 | PRG4 | HTA12-9-3 | Human | Pancreas | PDAC | 5.91e-13 | 1.20e+00 | 0.2045 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRG4 | SNV | Missense_Mutation | novel | c.2507C>G | p.Pro836Arg | p.P836R | Q92954 | protein_coding | deleterious(0) | benign(0.144) | TCGA-55-7910-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PRG4 | SNV | Missense_Mutation | c.1843N>A | p.Glu615Lys | p.E615K | Q92954 | protein_coding | tolerated(0.1) | benign(0.161) | TCGA-55-8094-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PRG4 | SNV | Missense_Mutation | c.328C>G | p.Pro110Ala | p.P110A | Q92954 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-55-8206-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRG4 | SNV | Missense_Mutation | c.1376N>A | p.Pro459His | p.P459H | Q92954 | protein_coding | deleterious(0) | benign(0.052) | TCGA-55-8207-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PRG4 | SNV | Missense_Mutation | c.1556N>T | p.Pro519Leu | p.P519L | Q92954 | protein_coding | deleterious(0) | possibly_damaging(0.562) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
PRG4 | SNV | Missense_Mutation | novel | c.574N>G | p.Arg192Gly | p.R192G | Q92954 | protein_coding | tolerated(0.07) | probably_damaging(0.946) | TCGA-69-8255-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRG4 | SNV | Missense_Mutation | novel | c.2749G>C | p.Asp917His | p.D917H | Q92954 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-83-5908-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRG4 | SNV | Missense_Mutation | c.2453N>A | p.Pro818His | p.P818H | Q92954 | protein_coding | deleterious(0) | benign(0.373) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRG4 | SNV | Missense_Mutation | c.40N>A | p.Leu14Met | p.L14M | Q92954 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRG4 | SNV | Missense_Mutation | novel | c.940G>C | p.Glu314Gln | p.E314Q | Q92954 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-L9-A743-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxotere | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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