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Gene: OGT |
Gene summary for OGT |
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Gene information | Species | Human | Gene symbol | OGT | Gene ID | 8473 |
Gene name | O-linked N-acetylglucosamine (GlcNAc) transferase | |
Gene Alias | HINCUT-1 | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | O15294 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8473 | OGT | LZE4T | Human | Esophagus | ESCC | 3.13e-08 | 4.64e-01 | 0.0811 |
8473 | OGT | LZE7T | Human | Esophagus | ESCC | 4.42e-18 | 8.47e-01 | 0.0667 |
8473 | OGT | LZE8T | Human | Esophagus | ESCC | 5.15e-13 | 2.98e-01 | 0.067 |
8473 | OGT | LZE20T | Human | Esophagus | ESCC | 4.39e-08 | 2.26e-01 | 0.0662 |
8473 | OGT | LZE22D1 | Human | Esophagus | HGIN | 3.33e-04 | 8.25e-02 | 0.0595 |
8473 | OGT | LZE22T | Human | Esophagus | ESCC | 1.83e-02 | 3.89e-01 | 0.068 |
8473 | OGT | LZE24T | Human | Esophagus | ESCC | 1.77e-39 | 1.34e+00 | 0.0596 |
8473 | OGT | LZE22D3 | Human | Esophagus | HGIN | 2.89e-02 | 2.67e-01 | 0.0653 |
8473 | OGT | LZE21T | Human | Esophagus | ESCC | 3.91e-05 | 4.84e-01 | 0.0655 |
8473 | OGT | LZE6T | Human | Esophagus | ESCC | 8.79e-09 | 1.67e-01 | 0.0845 |
8473 | OGT | P1T-E | Human | Esophagus | ESCC | 1.52e-13 | 6.89e-01 | 0.0875 |
8473 | OGT | P2T-E | Human | Esophagus | ESCC | 2.21e-19 | 3.27e-01 | 0.1177 |
8473 | OGT | P4T-E | Human | Esophagus | ESCC | 1.77e-15 | 2.25e-01 | 0.1323 |
8473 | OGT | P5T-E | Human | Esophagus | ESCC | 3.91e-19 | 1.75e-01 | 0.1327 |
8473 | OGT | P8T-E | Human | Esophagus | ESCC | 1.31e-32 | 7.17e-01 | 0.0889 |
8473 | OGT | P9T-E | Human | Esophagus | ESCC | 1.33e-12 | 3.89e-01 | 0.1131 |
8473 | OGT | P10T-E | Human | Esophagus | ESCC | 9.15e-33 | 4.55e-01 | 0.116 |
8473 | OGT | P11T-E | Human | Esophagus | ESCC | 8.05e-15 | 2.92e-01 | 0.1426 |
8473 | OGT | P12T-E | Human | Esophagus | ESCC | 7.59e-27 | 6.18e-01 | 0.1122 |
8473 | OGT | P15T-E | Human | Esophagus | ESCC | 1.15e-17 | 4.05e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603427 | Esophagus | HGIN | ATP metabolic process | 101/2587 | 277/18723 | 1.53e-21 | 1.02e-18 | 101 |
GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
GO:001049826 | Esophagus | HGIN | proteasomal protein catabolic process | 139/2587 | 490/18723 | 1.20e-17 | 3.41e-15 | 139 |
GO:004586227 | Esophagus | HGIN | positive regulation of proteolysis | 107/2587 | 372/18723 | 2.61e-14 | 4.60e-12 | 107 |
GO:004316126 | Esophagus | HGIN | proteasome-mediated ubiquitin-dependent protein catabolic process | 114/2587 | 412/18723 | 7.00e-14 | 1.20e-11 | 114 |
GO:190336227 | Esophagus | HGIN | regulation of cellular protein catabolic process | 81/2587 | 255/18723 | 1.16e-13 | 1.93e-11 | 81 |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:190305027 | Esophagus | HGIN | regulation of proteolysis involved in cellular protein catabolic process | 70/2587 | 221/18723 | 6.21e-12 | 7.76e-10 | 70 |
GO:006113627 | Esophagus | HGIN | regulation of proteasomal protein catabolic process | 60/2587 | 187/18723 | 1.10e-10 | 1.12e-08 | 60 |
GO:000989520 | Esophagus | HGIN | negative regulation of catabolic process | 87/2587 | 320/18723 | 1.74e-10 | 1.68e-08 | 87 |
GO:003139627 | Esophagus | HGIN | regulation of protein ubiquitination | 64/2587 | 210/18723 | 3.02e-10 | 2.71e-08 | 64 |
GO:003133026 | Esophagus | HGIN | negative regulation of cellular catabolic process | 74/2587 | 262/18723 | 6.27e-10 | 5.30e-08 | 74 |
GO:200005827 | Esophagus | HGIN | regulation of ubiquitin-dependent protein catabolic process | 53/2587 | 164/18723 | 9.89e-10 | 8.13e-08 | 53 |
GO:003243427 | Esophagus | HGIN | regulation of proteasomal ubiquitin-dependent protein catabolic process | 45/2587 | 134/18723 | 4.64e-09 | 3.12e-07 | 45 |
GO:190332127 | Esophagus | HGIN | negative regulation of protein modification by small protein conjugation or removal | 33/2587 | 95/18723 | 2.07e-07 | 9.95e-06 | 33 |
GO:003139727 | Esophagus | HGIN | negative regulation of protein ubiquitination | 30/2587 | 83/18723 | 2.72e-07 | 1.28e-05 | 30 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:004217720 | Esophagus | HGIN | negative regulation of protein catabolic process | 37/2587 | 121/18723 | 1.47e-06 | 5.56e-05 | 37 |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049318 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0493113 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa049316 | Liver | NAFLD | Insulin resistance | 29/1043 | 108/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 29 |
hsa0493111 | Liver | NAFLD | Insulin resistance | 29/1043 | 108/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 29 |
hsa0493121 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0493131 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa049317 | Oral cavity | OSCC | Insulin resistance | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
hsa0493112 | Oral cavity | OSCC | Insulin resistance | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
hsa0493122 | Oral cavity | EOLP | Insulin resistance | 25/1218 | 108/8465 | 9.53e-03 | 2.63e-02 | 1.55e-02 | 25 |
hsa0493132 | Oral cavity | EOLP | Insulin resistance | 25/1218 | 108/8465 | 9.53e-03 | 2.63e-02 | 1.55e-02 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OGT | deletion | Frame_Shift_Del | c.597delN | p.Cys199TrpfsTer33 | p.C199Wfs*33 | O15294 | protein_coding | TCGA-60-2715-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | PD | |||
OGT | SNV | Missense_Mutation | novel | c.1186N>A | p.Asp396Asn | p.D396N | O15294 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OGT | SNV | Missense_Mutation | novel | c.1256C>T | p.Thr419Met | p.T419M | O15294 | protein_coding | tolerated(0.09) | probably_damaging(0.975) | TCGA-CQ-6224-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
OGT | SNV | Missense_Mutation | novel | c.1258N>G | p.Arg420Gly | p.R420G | O15294 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
OGT | SNV | Missense_Mutation | novel | c.771N>G | p.Asn257Lys | p.N257K | O15294 | protein_coding | deleterious(0.03) | probably_damaging(0.931) | TCGA-QK-A6VC-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OGT | SNV | Missense_Mutation | c.394G>A | p.Ala132Thr | p.A132T | O15294 | protein_coding | tolerated(0.15) | probably_damaging(0.983) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OGT | SNV | Missense_Mutation | c.2630G>A | p.Arg877His | p.R877H | O15294 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | |
OGT | SNV | Missense_Mutation | novel | c.2174C>T | p.Ser725Phe | p.S725F | O15294 | protein_coding | deleterious(0.02) | benign(0.423) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
OGT | SNV | Missense_Mutation | novel | c.1502N>A | p.Arg501Lys | p.R501K | O15294 | protein_coding | tolerated(0.25) | probably_damaging(0.992) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
OGT | SNV | Missense_Mutation | novel | c.784C>T | p.His262Tyr | p.H262Y | O15294 | protein_coding | tolerated(0.44) | probably_damaging(0.993) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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