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Gene: OBSL1 |
Gene summary for OBSL1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | OBSL1 | Gene ID | 23363 |
Gene name | obscurin like cytoskeletal adaptor 1 | |
Gene Alias | OBSL1 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O75147 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23363 | OBSL1 | LZE8T | Human | Esophagus | ESCC | 9.25e-05 | 4.48e-02 | 0.067 |
23363 | OBSL1 | P2T-E | Human | Esophagus | ESCC | 2.55e-15 | 1.74e-01 | 0.1177 |
23363 | OBSL1 | P4T-E | Human | Esophagus | ESCC | 2.02e-06 | 8.24e-02 | 0.1323 |
23363 | OBSL1 | P5T-E | Human | Esophagus | ESCC | 3.55e-09 | 5.74e-02 | 0.1327 |
23363 | OBSL1 | P8T-E | Human | Esophagus | ESCC | 1.10e-17 | 2.64e-01 | 0.0889 |
23363 | OBSL1 | P9T-E | Human | Esophagus | ESCC | 2.73e-12 | 1.63e-01 | 0.1131 |
23363 | OBSL1 | P10T-E | Human | Esophagus | ESCC | 5.78e-26 | 9.04e-02 | 0.116 |
23363 | OBSL1 | P11T-E | Human | Esophagus | ESCC | 9.15e-03 | 2.82e-01 | 0.1426 |
23363 | OBSL1 | P12T-E | Human | Esophagus | ESCC | 1.15e-20 | 1.42e-01 | 0.1122 |
23363 | OBSL1 | P15T-E | Human | Esophagus | ESCC | 9.69e-16 | 1.08e-01 | 0.1149 |
23363 | OBSL1 | P16T-E | Human | Esophagus | ESCC | 1.06e-15 | 2.18e-01 | 0.1153 |
23363 | OBSL1 | P17T-E | Human | Esophagus | ESCC | 4.24e-02 | 7.30e-02 | 0.1278 |
23363 | OBSL1 | P20T-E | Human | Esophagus | ESCC | 6.30e-09 | 1.52e-01 | 0.1124 |
23363 | OBSL1 | P21T-E | Human | Esophagus | ESCC | 1.71e-20 | 2.23e-01 | 0.1617 |
23363 | OBSL1 | P22T-E | Human | Esophagus | ESCC | 5.94e-22 | 1.08e-01 | 0.1236 |
23363 | OBSL1 | P23T-E | Human | Esophagus | ESCC | 9.25e-03 | -6.90e-02 | 0.108 |
23363 | OBSL1 | P24T-E | Human | Esophagus | ESCC | 1.23e-13 | 1.59e-02 | 0.1287 |
23363 | OBSL1 | P26T-E | Human | Esophagus | ESCC | 8.48e-15 | 6.04e-02 | 0.1276 |
23363 | OBSL1 | P27T-E | Human | Esophagus | ESCC | 4.27e-13 | 8.10e-02 | 0.1055 |
23363 | OBSL1 | P28T-E | Human | Esophagus | ESCC | 1.30e-09 | 8.27e-02 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00070883 | Esophagus | ESCC | regulation of mitotic nuclear division | 78/8552 | 110/18723 | 6.96e-08 | 1.21e-06 | 78 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00517831 | Esophagus | ESCC | regulation of nuclear division | 90/8552 | 139/18723 | 4.30e-06 | 4.60e-05 | 90 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:00340676 | Esophagus | ESCC | protein localization to Golgi apparatus | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:001076920 | Esophagus | ESCC | regulation of cell morphogenesis involved in differentiation | 61/8552 | 96/18723 | 3.12e-04 | 1.85e-03 | 61 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:001077018 | Esophagus | ESCC | positive regulation of cell morphogenesis involved in differentiation | 51/8552 | 79/18723 | 5.48e-04 | 3.00e-03 | 51 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:006053716 | Esophagus | ESCC | muscle tissue development | 211/8552 | 403/18723 | 3.84e-03 | 1.56e-02 | 211 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OBSL1 | SNV | Missense_Mutation | rs535601955 | c.2915T>C | p.Ile972Thr | p.I972T | O75147 | protein_coding | tolerated(0.29) | benign(0.34) | TCGA-2Y-A9HA-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
OBSL1 | SNV | Missense_Mutation | rs750084343 | c.3134N>A | p.Arg1045His | p.R1045H | O75147 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-DD-AACT-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OBSL1 | SNV | Missense_Mutation | novel | c.3803G>T | p.Arg1268Leu | p.R1268L | O75147 | protein_coding | tolerated(0.34) | possibly_damaging(0.724) | TCGA-DD-AAEB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OBSL1 | SNV | Missense_Mutation | c.3599C>T | p.Ala1200Val | p.A1200V | O75147 | protein_coding | tolerated(0.26) | probably_damaging(0.963) | TCGA-MI-A75H-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OBSL1 | deletion | Frame_Shift_Del | c.427delN | p.Ala143ArgfsTer5 | p.A143Rfs*5 | O75147 | protein_coding | TCGA-WQ-A9G7-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
OBSL1 | SNV | Missense_Mutation | rs754529663 | c.4908N>A | p.His1636Gln | p.H1636Q | O75147 | protein_coding | tolerated(1) | benign(0) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
OBSL1 | SNV | Missense_Mutation | novel | c.1776N>G | p.Ile592Met | p.I592M | O75147 | protein_coding | deleterious(0) | benign(0.221) | TCGA-44-2662-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Other, specify in notesGSK Mage Vaccine Study | rec | PD |
OBSL1 | SNV | Missense_Mutation | c.3572T>C | p.Val1191Ala | p.V1191A | O75147 | protein_coding | tolerated(0.24) | possibly_damaging(0.855) | TCGA-44-6774-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | alimta | SD | |
OBSL1 | SNV | Missense_Mutation | c.1297C>T | p.Arg433Cys | p.R433C | O75147 | protein_coding | deleterious(0) | possibly_damaging(0.667) | TCGA-44-7671-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
OBSL1 | SNV | Missense_Mutation | c.2907N>T | p.Leu969Phe | p.L969F | O75147 | protein_coding | deleterious(0.02) | possibly_damaging(0.678) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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