![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NWD1 |
Gene summary for NWD1 |
![]() |
Gene information | Species | Human | Gene symbol | NWD1 | Gene ID | 284434 |
Gene name | NACHT and WD repeat domain containing 1 | |
Gene Alias | NWD1 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q149M9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284434 | NWD1 | HCC1 | Human | Liver | HCC | 7.03e-21 | 2.11e+00 | 0.5336 |
284434 | NWD1 | HCC2 | Human | Liver | HCC | 2.75e-38 | 2.24e+00 | 0.5341 |
284434 | NWD1 | HCC5 | Human | Liver | HCC | 4.48e-36 | 2.11e+00 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NWD1 | SNV | Missense_Mutation | novel | c.3883N>T | p.Pro1295Ser | p.P1295S | Q149M9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NWD1 | SNV | Missense_Mutation | novel | c.3884N>T | p.Pro1295Leu | p.P1295L | Q149M9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NWD1 | SNV | Missense_Mutation | c.2242N>C | p.Glu748Gln | p.E748Q | Q149M9 | protein_coding | deleterious(0.01) | possibly_damaging(0.603) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
NWD1 | insertion | Frame_Shift_Ins | novel | c.1003_1004insC | p.Leu337ProfsTer20 | p.L337Pfs*20 | Q149M9 | protein_coding | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
NWD1 | SNV | Missense_Mutation | novel | c.832N>T | p.Leu278Phe | p.L278F | Q149M9 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NWD1 | SNV | Missense_Mutation | rs556816698 | c.1880N>A | p.Pro627Gln | p.P627Q | Q149M9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
NWD1 | SNV | Missense_Mutation | novel | c.3129N>G | p.Ile1043Met | p.I1043M | Q149M9 | protein_coding | tolerated(0.17) | benign(0.006) | TCGA-CV-7103-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
NWD1 | SNV | Missense_Mutation | rs571275303 | c.1489N>A | p.Gly497Arg | p.G497R | Q149M9 | protein_coding | tolerated(0.54) | benign(0.023) | TCGA-CV-7261-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NWD1 | SNV | Missense_Mutation | rs778568082 | c.2722N>A | p.Gly908Arg | p.G908R | Q149M9 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NWD1 | SNV | Missense_Mutation | c.3157T>G | p.Ser1053Ala | p.S1053A | Q149M9 | protein_coding | tolerated(0.96) | benign(0.025) | TCGA-G9-6499-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |