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Gene: NRXN1 |
Gene summary for NRXN1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NRXN1 | Gene ID | 9378 |
Gene name | neurexin 1 | |
Gene Alias | Hs.22998 | |
Cytomap | 2p16.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9ULB1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9378 | NRXN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.63e-03 | 2.37e-01 | -0.0811 |
9378 | NRXN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.07e-05 | 2.03e-01 | -0.1954 |
9378 | NRXN1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.11e-02 | 3.39e-01 | -0.2196 |
9378 | NRXN1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.05e-06 | 2.92e-01 | -0.1207 |
9378 | NRXN1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.31e-10 | 3.13e-01 | -0.1464 |
9378 | NRXN1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.03e-04 | 2.00e-01 | -0.1001 |
9378 | NRXN1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.13e-13 | 3.27e-01 | -0.059 |
9378 | NRXN1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.27e-02 | 2.52e-01 | -0.2061 |
9378 | NRXN1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-04 | 2.32e-01 | -0.0842 |
9378 | NRXN1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.09e-03 | 5.57e-01 | 0.3487 |
9378 | NRXN1 | HTA12-15-2 | Human | Pancreas | PDAC | 2.97e-13 | 9.78e-01 | 0.2315 |
9378 | NRXN1 | HTA12-23-1 | Human | Pancreas | PDAC | 2.88e-24 | 1.70e+00 | 0.3405 |
9378 | NRXN1 | HTA12-25-1 | Human | Pancreas | PDAC | 3.81e-22 | 1.55e+00 | 0.313 |
9378 | NRXN1 | HTA12-26-1 | Human | Pancreas | PDAC | 2.71e-57 | 1.96e+00 | 0.3728 |
9378 | NRXN1 | HTA12-29-1 | Human | Pancreas | PDAC | 8.43e-121 | 1.97e+00 | 0.3722 |
9378 | NRXN1 | HTA12-30-1 | Human | Pancreas | PDAC | 3.11e-06 | 1.61e+00 | 0.3671 |
9378 | NRXN1 | HTA12-32-1 | Human | Pancreas | PDAC | 1.97e-13 | 1.73e+00 | 0.3624 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0071709 | Colorectum | AD | membrane assembly | 22/3918 | 50/18723 | 2.00e-04 | 2.66e-03 | 22 |
GO:0044091 | Colorectum | AD | membrane biogenesis | 22/3918 | 55/18723 | 9.88e-04 | 9.28e-03 | 22 |
GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:0007411 | Colorectum | AD | axon guidance | 64/3918 | 227/18723 | 5.41e-03 | 3.55e-02 | 64 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:0097485 | Colorectum | AD | neuron projection guidance | 64/3918 | 228/18723 | 6.02e-03 | 3.78e-02 | 64 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00717091 | Colorectum | SER | membrane assembly | 20/2897 | 50/18723 | 2.45e-05 | 6.84e-04 | 20 |
GO:00991731 | Colorectum | SER | postsynapse organization | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00440911 | Colorectum | SER | membrane biogenesis | 20/2897 | 55/18723 | 1.21e-04 | 2.49e-03 | 20 |
GO:00074111 | Colorectum | SER | axon guidance | 51/2897 | 227/18723 | 3.29e-03 | 2.82e-02 | 51 |
GO:00974851 | Colorectum | SER | neuron projection guidance | 51/2897 | 228/18723 | 3.61e-03 | 3.03e-02 | 51 |
GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
GO:19018881 | Colorectum | SER | regulation of cell junction assembly | 46/2897 | 204/18723 | 4.70e-03 | 3.70e-02 | 46 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
NRXN1 | NLGN1 | NRXN1_NLGN1 | NRXN | CRC | ADJ |
NRXN1 | NLGN1 | NRXN1_NLGN1 | NRXN | Endometrium | ADJ |
NRXN1 | NLGN1 | NRXN1_NLGN1 | NRXN | GC | ADJ |
NRXN1 | NLGN1 | NRXN1_NLGN1 | NRXN | Skin | SCCIS |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRXN1 | SNV | Missense_Mutation | c.3512N>T | p.Gly1171Val | p.G1171V | Q9ULB1 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
NRXN1 | SNV | Missense_Mutation | c.1079N>T | p.Ser360Leu | p.S360L | Q9ULB1 | protein_coding | deleterious(0.01) | possibly_damaging(0.786) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
NRXN1 | SNV | Missense_Mutation | novel | c.4489N>C | p.Asn1497His | p.N1497H | Q9ULB1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
NRXN1 | SNV | Missense_Mutation | c.3931N>T | p.Arg1311Cys | p.R1311C | Q9ULB1 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
NRXN1 | SNV | Missense_Mutation | rs200391188 | c.2456N>T | p.Thr819Met | p.T819M | Q9ULB1 | protein_coding | tolerated(0.14) | possibly_damaging(0.901) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
NRXN1 | SNV | Missense_Mutation | c.3922G>A | p.Asp1308Asn | p.D1308N | Q9ULB1 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
NRXN1 | SNV | Missense_Mutation | novel | c.2404G>T | p.Asp802Tyr | p.D802Y | Q9ULB1 | protein_coding | deleterious(0) | possibly_damaging(0.447) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
NRXN1 | SNV | Missense_Mutation | novel | c.965C>A | p.Ser322Tyr | p.S322Y | Q9ULB1 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
NRXN1 | SNV | Missense_Mutation | rs200202367 | c.493N>A | p.Ala165Thr | p.A165T | Q9ULB1 | protein_coding | tolerated(0.14) | benign(0.065) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NRXN1 | SNV | Missense_Mutation | novel | c.2911T>A | p.Phe971Ile | p.F971I | Q9ULB1 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9378 | NRXN1 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME, TRANSPORTER | antipsychotics | |||
9378 | NRXN1 | CELL SURFACE, ION CHANNEL, DRUGGABLE GENOME, TRANSPORTER | duloxetine | DULOXETINE | 29407288 |
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