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Gene: NRP2 |
Gene summary for NRP2 |
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Gene information | Species | Human | Gene symbol | NRP2 | Gene ID | 8828 |
Gene name | neuropilin 2 | |
Gene Alias | NP2 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O60462 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8828 | NRP2 | LZE8T | Human | Esophagus | ESCC | 1.04e-04 | -3.23e-01 | 0.067 |
8828 | NRP2 | LZE22T | Human | Esophagus | ESCC | 5.88e-03 | -9.38e-02 | 0.068 |
8828 | NRP2 | LZE24T | Human | Esophagus | ESCC | 1.08e-02 | -3.65e-01 | 0.0596 |
8828 | NRP2 | P2T-E | Human | Esophagus | ESCC | 6.28e-07 | 3.44e-01 | 0.1177 |
8828 | NRP2 | P4T-E | Human | Esophagus | ESCC | 1.04e-16 | 8.17e-01 | 0.1323 |
8828 | NRP2 | P5T-E | Human | Esophagus | ESCC | 2.63e-03 | 2.00e-01 | 0.1327 |
8828 | NRP2 | P8T-E | Human | Esophagus | ESCC | 1.98e-05 | 2.14e-01 | 0.0889 |
8828 | NRP2 | P9T-E | Human | Esophagus | ESCC | 1.25e-04 | 1.26e-01 | 0.1131 |
8828 | NRP2 | P10T-E | Human | Esophagus | ESCC | 2.06e-09 | 2.58e-01 | 0.116 |
8828 | NRP2 | P11T-E | Human | Esophagus | ESCC | 3.67e-03 | 3.99e-01 | 0.1426 |
8828 | NRP2 | P15T-E | Human | Esophagus | ESCC | 9.90e-03 | 3.07e-01 | 0.1149 |
8828 | NRP2 | P16T-E | Human | Esophagus | ESCC | 8.62e-16 | -4.12e-01 | 0.1153 |
8828 | NRP2 | P17T-E | Human | Esophagus | ESCC | 2.09e-03 | 2.12e-01 | 0.1278 |
8828 | NRP2 | P19T-E | Human | Esophagus | ESCC | 3.06e-03 | 4.63e-01 | 0.1662 |
8828 | NRP2 | P21T-E | Human | Esophagus | ESCC | 1.28e-22 | 7.63e-01 | 0.1617 |
8828 | NRP2 | P22T-E | Human | Esophagus | ESCC | 6.58e-07 | -9.53e-02 | 0.1236 |
8828 | NRP2 | P23T-E | Human | Esophagus | ESCC | 2.36e-04 | 4.89e-01 | 0.108 |
8828 | NRP2 | P24T-E | Human | Esophagus | ESCC | 6.43e-09 | 4.13e-01 | 0.1287 |
8828 | NRP2 | P26T-E | Human | Esophagus | ESCC | 2.77e-25 | 1.07e+00 | 0.1276 |
8828 | NRP2 | P27T-E | Human | Esophagus | ESCC | 5.09e-17 | 7.27e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:199082316 | Esophagus | ESCC | response to leukemia inhibitory factor | 60/8552 | 95/18723 | 4.41e-04 | 2.48e-03 | 60 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:199083015 | Esophagus | ESCC | cellular response to leukemia inhibitory factor | 59/8552 | 94/18723 | 6.19e-04 | 3.32e-03 | 59 |
GO:006056010 | Esophagus | ESCC | developmental growth involved in morphogenesis | 131/8552 | 234/18723 | 9.28e-04 | 4.73e-03 | 131 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:001063120 | Esophagus | ESCC | epithelial cell migration | 187/8552 | 357/18723 | 6.05e-03 | 2.23e-02 | 187 |
GO:009013220 | Esophagus | ESCC | epithelium migration | 188/8552 | 360/18723 | 6.96e-03 | 2.54e-02 | 188 |
GO:009013020 | Esophagus | ESCC | tissue migration | 190/8552 | 365/18723 | 7.91e-03 | 2.82e-02 | 190 |
GO:004858810 | Esophagus | ESCC | developmental cell growth | 125/8552 | 234/18723 | 1.01e-02 | 3.46e-02 | 125 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:004867511 | Liver | HCC | axon extension | 67/7958 | 120/18723 | 2.17e-03 | 1.09e-02 | 67 |
GO:199013811 | Liver | HCC | neuron projection extension | 92/7958 | 172/18723 | 2.31e-03 | 1.14e-02 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SEMA3D | NRP2_PLXNA2 | SEMA3D_NRP2_PLXNA2 | SEMA3 | Breast | ADJ |
SEMA3C | NRP1_NRP2 | SEMA3C_NRP1_NRP2 | SEMA3 | Breast | DCIS |
SEMA3C | NRP2_PLXNA2 | SEMA3C_NRP2_PLXNA2 | SEMA3 | Breast | Healthy |
SEMA3D | NRP2_PLXNA2 | SEMA3D_NRP2_PLXNA2 | SEMA3 | Breast | Healthy |
SEMA3C | NRP1_NRP2 | SEMA3C_NRP1_NRP2 | SEMA3 | Breast | Healthy |
SEMA3C | NRP1_NRP2 | SEMA3C_NRP1_NRP2 | SEMA3 | Cervix | ADJ |
SEMA3C | NRP2_PLXNA2 | SEMA3C_NRP2_PLXNA2 | SEMA3 | Cervix | CC |
SEMA3F | NRP2_PLXNA2 | SEMA3F_NRP2_PLXNA2 | SEMA3 | Cervix | CC |
SEMA3C | NRP1_NRP2 | SEMA3C_NRP1_NRP2 | SEMA3 | Cervix | CC |
SEMA3C | NRP1_NRP2 | SEMA3C_NRP1_NRP2 | SEMA3 | Cervix | Precancer |
SEMA3C | NRP2_PLXNA2 | SEMA3C_NRP2_PLXNA2 | SEMA3 | CRC | AD |
SEMA3F | NRP2_PLXNA2 | SEMA3F_NRP2_PLXNA2 | SEMA3 | CRC | AD |
SEMA3C | NRP1_NRP2 | SEMA3C_NRP1_NRP2 | SEMA3 | CRC | AD |
SEMA3B | NRP2_PLXNA2 | SEMA3B_NRP2_PLXNA2 | SEMA3 | CRC | ADJ |
SEMA3C | NRP2_PLXNA2 | SEMA3C_NRP2_PLXNA2 | SEMA3 | CRC | ADJ |
SEMA3B | NRP2_PLXNA2 | SEMA3B_NRP2_PLXNA2 | SEMA3 | CRC | FAP |
SEMA3C | NRP2_PLXNA2 | SEMA3C_NRP2_PLXNA2 | SEMA3 | CRC | FAP |
SEMA3B | NRP2_PLXNA2 | SEMA3B_NRP2_PLXNA2 | SEMA3 | CRC | MSI-H |
SEMA3C | NRP2_PLXNA2 | SEMA3C_NRP2_PLXNA2 | SEMA3 | CRC | MSI-H |
SEMA3F | NRP2_PLXNA2 | SEMA3F_NRP2_PLXNA2 | SEMA3 | CRC | MSI-H |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRP2 | SNV | Missense_Mutation | novel | c.1397N>A | p.Arg466His | p.R466H | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |
NRP2 | SNV | Missense_Mutation | novel | c.2041N>T | p.Pro681Ser | p.P681S | protein_coding | tolerated(0.28) | benign(0.011) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |
NRP2 | SNV | Missense_Mutation | c.1228N>T | p.Arg410Cys | p.R410C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A91W-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR | ||
NRP2 | insertion | Frame_Shift_Ins | novel | c.2182dupG | p.Val728GlyfsTer21 | p.V728Gfs*21 | protein_coding | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8828 | NRP2 | NA | daunorubicin | DAUNORUBICIN | 18451141 |
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