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Gene: NRCAM |
Gene summary for NRCAM |
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Gene information | Species | Human | Gene symbol | NRCAM | Gene ID | 4897 |
Gene name | neuronal cell adhesion molecule | |
Gene Alias | NRCAM | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q14CA1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4897 | NRCAM | AEH-subject1 | Human | Endometrium | AEH | 1.04e-03 | 2.64e-01 | -0.3059 |
4897 | NRCAM | AEH-subject2 | Human | Endometrium | AEH | 1.69e-07 | 3.42e-01 | -0.2525 |
4897 | NRCAM | EEC-subject1 | Human | Endometrium | EEC | 4.32e-35 | 7.76e-01 | -0.2682 |
4897 | NRCAM | EEC-subject2 | Human | Endometrium | EEC | 1.96e-05 | 3.68e-01 | -0.2607 |
4897 | NRCAM | EEC-subject5 | Human | Endometrium | EEC | 7.89e-11 | 4.22e-01 | -0.249 |
4897 | NRCAM | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.43e-02 | 1.89e-01 | -0.1934 |
4897 | NRCAM | LZE7T | Human | Esophagus | ESCC | 2.41e-06 | 5.29e-01 | 0.0667 |
4897 | NRCAM | P9T-E | Human | Esophagus | ESCC | 1.71e-09 | 2.75e-01 | 0.1131 |
4897 | NRCAM | P12T-E | Human | Esophagus | ESCC | 1.42e-10 | 3.46e-01 | 0.1122 |
4897 | NRCAM | P16T-E | Human | Esophagus | ESCC | 1.31e-11 | 3.05e-01 | 0.1153 |
4897 | NRCAM | P26T-E | Human | Esophagus | ESCC | 1.37e-23 | 7.63e-01 | 0.1276 |
4897 | NRCAM | P27T-E | Human | Esophagus | ESCC | 2.86e-04 | 2.35e-01 | 0.1055 |
4897 | NRCAM | P30T-E | Human | Esophagus | ESCC | 1.53e-02 | 1.68e-01 | 0.137 |
4897 | NRCAM | P32T-E | Human | Esophagus | ESCC | 7.98e-04 | 1.71e-01 | 0.1666 |
4897 | NRCAM | P48T-E | Human | Esophagus | ESCC | 1.63e-06 | 1.92e-01 | 0.0959 |
4897 | NRCAM | P52T-E | Human | Esophagus | ESCC | 5.76e-11 | 3.64e-01 | 0.1555 |
4897 | NRCAM | P61T-E | Human | Esophagus | ESCC | 1.69e-10 | 2.39e-01 | 0.099 |
4897 | NRCAM | P74T-E | Human | Esophagus | ESCC | 1.97e-04 | 2.08e-01 | 0.1479 |
4897 | NRCAM | P76T-E | Human | Esophagus | ESCC | 3.31e-07 | 1.64e-01 | 0.1207 |
4897 | NRCAM | P83T-E | Human | Esophagus | ESCC | 1.17e-09 | 3.21e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160499 | Endometrium | AEH | cell growth | 93/2100 | 482/18723 | 1.00e-07 | 4.99e-06 | 93 |
GO:003253510 | Endometrium | AEH | regulation of cellular component size | 78/2100 | 383/18723 | 1.10e-07 | 5.29e-06 | 78 |
GO:00605607 | Endometrium | AEH | developmental growth involved in morphogenesis | 53/2100 | 234/18723 | 4.02e-07 | 1.67e-05 | 53 |
GO:00074098 | Endometrium | AEH | axonogenesis | 81/2100 | 418/18723 | 5.54e-07 | 2.12e-05 | 81 |
GO:00615648 | Endometrium | AEH | axon development | 88/2100 | 467/18723 | 6.39e-07 | 2.38e-05 | 88 |
GO:00343299 | Endometrium | AEH | cell junction assembly | 78/2100 | 420/18723 | 4.80e-06 | 1.24e-04 | 78 |
GO:00486757 | Endometrium | AEH | axon extension | 31/2100 | 120/18723 | 6.13e-06 | 1.50e-04 | 31 |
GO:00015589 | Endometrium | AEH | regulation of cell growth | 75/2100 | 414/18723 | 1.79e-05 | 3.65e-04 | 75 |
GO:00485887 | Endometrium | AEH | developmental cell growth | 48/2100 | 234/18723 | 2.39e-05 | 4.53e-04 | 48 |
GO:19901386 | Endometrium | AEH | neuron projection extension | 38/2100 | 172/18723 | 3.03e-05 | 5.56e-04 | 38 |
GO:00083616 | Endometrium | AEH | regulation of cell size | 38/2100 | 181/18723 | 9.69e-05 | 1.40e-03 | 38 |
GO:00486387 | Endometrium | AEH | regulation of developmental growth | 58/2100 | 330/18723 | 3.45e-04 | 3.80e-03 | 58 |
GO:00017642 | Endometrium | AEH | neuron migration | 31/2100 | 156/18723 | 1.08e-03 | 9.46e-03 | 31 |
GO:00613872 | Endometrium | AEH | regulation of extent of cell growth | 23/2100 | 110/18723 | 2.27e-03 | 1.74e-02 | 23 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
GO:00305166 | Endometrium | AEH | regulation of axon extension | 20/2100 | 95/18723 | 3.91e-03 | 2.64e-02 | 20 |
GO:006156412 | Endometrium | EEC | axon development | 93/2168 | 467/18723 | 9.60e-08 | 4.69e-06 | 93 |
GO:001604915 | Endometrium | EEC | cell growth | 95/2168 | 482/18723 | 1.16e-07 | 5.54e-06 | 95 |
GO:003253516 | Endometrium | EEC | regulation of cellular component size | 79/2168 | 383/18723 | 1.98e-07 | 8.93e-06 | 79 |
GO:006056013 | Endometrium | EEC | developmental growth involved in morphogenesis | 54/2168 | 234/18723 | 4.60e-07 | 1.78e-05 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CNTN1 | NRCAM | CNTN1_NRCAM | CNTN | HNSCC | Precancer |
CNTN1 | NRCAM | CNTN1_NRCAM | CNTN | Skin | AK |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRCAM | SNV | Missense_Mutation | novel | c.2425N>C | p.Ser809Pro | p.S809P | Q92823 | protein_coding | tolerated(0.2) | benign(0.258) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NRCAM | SNV | Missense_Mutation | c.47N>A | p.Arg16Lys | p.R16K | Q92823 | protein_coding | tolerated(1) | benign(0) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRCAM | SNV | Missense_Mutation | c.3479N>T | p.Arg1160Leu | p.R1160L | Q92823 | protein_coding | tolerated(0.11) | possibly_damaging(0.458) | TCGA-73-4677-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NRCAM | SNV | Missense_Mutation | c.2548G>T | p.Gly850Trp | p.G850W | Q92823 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-78-7156-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NRCAM | SNV | Missense_Mutation | c.817C>A | p.Pro273Thr | p.P273T | Q92823 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
NRCAM | SNV | Missense_Mutation | c.2095N>A | p.Glu699Lys | p.E699K | Q92823 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NRCAM | SNV | Missense_Mutation | rs760065961 | c.1142T>C | p.Ile381Thr | p.I381T | Q92823 | protein_coding | tolerated(0.48) | benign(0.019) | TCGA-86-8359-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
NRCAM | SNV | Missense_Mutation | c.2496N>T | p.Glu832Asp | p.E832D | Q92823 | protein_coding | tolerated(0.11) | benign(0.079) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NRCAM | SNV | Missense_Mutation | rs374383279 | c.1576G>T | p.Val526Phe | p.V526F | Q92823 | protein_coding | deleterious(0.02) | benign(0.274) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NRCAM | SNV | Missense_Mutation | rs201534122 | c.2411C>G | p.Ser804Cys | p.S804C | Q92823 | protein_coding | tolerated(0.05) | possibly_damaging(0.766) | TCGA-L9-A5IP-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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