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Gene: NLRP8 |
Gene summary for NLRP8 |
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Gene information | Species | Human | Gene symbol | NLRP8 | Gene ID | 126205 |
Gene name | NLR family pyrin domain containing 8 | |
Gene Alias | CLR19.2 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86W28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126205 | NLRP8 | HCC1 | Human | Liver | HCC | 3.12e-03 | 2.91e-01 | 0.5336 |
126205 | NLRP8 | HCC2 | Human | Liver | HCC | 8.19e-10 | 5.04e-01 | 0.5341 |
126205 | NLRP8 | HCC5 | Human | Liver | HCC | 5.72e-12 | 5.53e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NLRP8 | SNV | Missense_Mutation | novel | c.1216N>A | p.Leu406Met | p.L406M | Q86W28 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-43-A56U-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | novel | c.2564N>T | p.Thr855Ile | p.T855I | Q86W28 | protein_coding | tolerated(0.09) | benign(0) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NLRP8 | SNV | Missense_Mutation | novel | c.2036N>T | p.Gly679Val | p.G679V | Q86W28 | protein_coding | tolerated(0.4) | benign(0.013) | TCGA-56-A49D-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | c.967N>C | p.Thr323Pro | p.T323P | Q86W28 | protein_coding | tolerated(0.17) | benign(0.233) | TCGA-60-2708-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
NLRP8 | SNV | Missense_Mutation | c.3020G>A | p.Ser1007Asn | p.S1007N | Q86W28 | protein_coding | tolerated(0.44) | benign(0.048) | TCGA-66-2770-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NLRP8 | SNV | Missense_Mutation | novel | c.1988C>A | p.Thr663Asn | p.T663N | Q86W28 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-68-8250-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | novel | c.2959N>T | p.Asp987Tyr | p.D987Y | Q86W28 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-6A-AB49-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | novel | c.1443N>T | p.Gln481His | p.Q481H | Q86W28 | protein_coding | deleterious(0.01) | possibly_damaging(0.629) | TCGA-77-7139-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | rs745723781 | c.95A>T | p.Tyr32Phe | p.Y32F | Q86W28 | protein_coding | tolerated_low_confidence(0.7) | benign(0.071) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | c.2402N>A | p.Thr801Asn | p.T801N | Q86W28 | protein_coding | tolerated(0.08) | possibly_damaging(0.898) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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