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Gene: NID2 |
Gene summary for NID2 |
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Gene information | Species | Human | Gene symbol | NID2 | Gene ID | 22795 |
Gene name | nidogen 2 | |
Gene Alias | NID-2 | |
Cytomap | 14q22.1 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q14112 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22795 | NID2 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 3.65e-02 | -2.84e-01 | 0.02 |
22795 | NID2 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 2.18e-03 | -2.89e-01 | 0.0267 |
22795 | NID2 | PTCwithHT_6 | Human | Thyroid | HT | 1.19e-03 | -2.85e-01 | 0.02 |
22795 | NID2 | PTCwithHT_8 | Human | Thyroid | HT | 5.43e-04 | -2.89e-01 | 0.0351 |
22795 | NID2 | male-WTA | Human | Thyroid | PTC | 1.57e-57 | 4.23e-01 | 0.1037 |
22795 | NID2 | PTC01 | Human | Thyroid | PTC | 8.99e-13 | 3.39e-03 | 0.1899 |
22795 | NID2 | PTC04 | Human | Thyroid | PTC | 6.94e-08 | -7.60e-02 | 0.1927 |
22795 | NID2 | PTC06 | Human | Thyroid | PTC | 4.83e-24 | 9.48e-01 | 0.2057 |
22795 | NID2 | PTC07 | Human | Thyroid | PTC | 7.73e-19 | 3.59e-01 | 0.2044 |
22795 | NID2 | ATC09 | Human | Thyroid | ATC | 4.01e-02 | 3.41e-01 | 0.2871 |
22795 | NID2 | ATC12 | Human | Thyroid | ATC | 1.50e-19 | 6.76e-01 | 0.34 |
22795 | NID2 | ATC13 | Human | Thyroid | ATC | 2.88e-12 | 1.91e-01 | 0.34 |
22795 | NID2 | ATC1 | Human | Thyroid | ATC | 2.17e-03 | 4.40e-01 | 0.2878 |
22795 | NID2 | ATC3 | Human | Thyroid | ATC | 3.19e-02 | -4.84e-02 | 0.338 |
22795 | NID2 | ATC4 | Human | Thyroid | ATC | 3.50e-26 | 8.58e-01 | 0.34 |
22795 | NID2 | ATC5 | Human | Thyroid | ATC | 1.19e-15 | 2.45e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158927 | Thyroid | HT | cell-substrate adhesion | 41/1272 | 363/18723 | 9.54e-04 | 9.83e-03 | 41 |
GO:0031589111 | Thyroid | PTC | cell-substrate adhesion | 169/5968 | 363/18723 | 2.73e-09 | 7.57e-08 | 169 |
GO:000716020 | Thyroid | PTC | cell-matrix adhesion | 109/5968 | 233/18723 | 1.28e-06 | 1.84e-05 | 109 |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:00717116 | Thyroid | PTC | basement membrane organization | 19/5968 | 31/18723 | 7.02e-04 | 4.39e-03 | 19 |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:0007160111 | Thyroid | ATC | cell-matrix adhesion | 128/6293 | 233/18723 | 1.49e-11 | 5.41e-10 | 128 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:007171113 | Thyroid | ATC | basement membrane organization | 20/6293 | 31/18723 | 4.20e-04 | 2.51e-03 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NID2 | SNV | Missense_Mutation | novel | c.82N>C | p.Ala28Pro | p.A28P | Q14112 | protein_coding | deleterious(0.04) | benign(0.193) | TCGA-ZS-A9CG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NID2 | SNV | Missense_Mutation | novel | c.436C>T | p.Arg146Cys | p.R146C | Q14112 | protein_coding | tolerated(0.08) | benign(0.27) | TCGA-05-4420-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NID2 | SNV | Missense_Mutation | novel | c.2006N>A | p.Leu669Gln | p.L669Q | Q14112 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
NID2 | SNV | Missense_Mutation | novel | c.740N>A | p.Thr247Asn | p.T247N | Q14112 | protein_coding | tolerated(0.4) | benign(0.043) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
NID2 | SNV | Missense_Mutation | novel | c.2629N>G | p.Cys877Gly | p.C877G | Q14112 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-38-4629-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NID2 | SNV | Missense_Mutation | c.1124G>T | p.Gly375Val | p.G375V | Q14112 | protein_coding | tolerated(0.25) | benign(0) | TCGA-44-3398-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NID2 | SNV | Missense_Mutation | c.2039N>G | p.Thr680Arg | p.T680R | Q14112 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
NID2 | SNV | Missense_Mutation | novel | c.2158N>T | p.Thr720Ser | p.T720S | Q14112 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-53-A4EZ-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
NID2 | SNV | Missense_Mutation | c.2437N>T | p.Gly813Cys | p.G813C | Q14112 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NID2 | SNV | Missense_Mutation | c.2540N>A | p.Pro847Gln | p.P847Q | Q14112 | protein_coding | tolerated(0.17) | possibly_damaging(0.53) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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