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Gene: INPP5D |
Gene summary for INPP5D |
Gene summary. |
Gene information | Species | Human | Gene symbol | INPP5D | Gene ID | 3635 |
Gene name | inositol polyphosphate-5-phosphatase D | |
Gene Alias | SHIP | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q92835 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3635 | INPP5D | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.77e-23 | 3.86e-01 | 0.0155 |
3635 | INPP5D | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.03e-06 | 2.53e-01 | -0.1808 |
3635 | INPP5D | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.03e-07 | 5.92e-01 | 0.0216 |
3635 | INPP5D | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.24e-26 | 6.62e-01 | -0.0811 |
3635 | INPP5D | HTA11_78_2000001011 | Human | Colorectum | AD | 7.84e-13 | 3.98e-01 | -0.1088 |
3635 | INPP5D | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.75e-08 | 1.97e-01 | -0.1207 |
3635 | INPP5D | HTA11_83_2000001011 | Human | Colorectum | SER | 4.77e-05 | 3.69e-01 | -0.1526 |
3635 | INPP5D | HTA11_696_2000001011 | Human | Colorectum | AD | 2.81e-02 | 1.05e-01 | -0.1464 |
3635 | INPP5D | HTA11_866_2000001011 | Human | Colorectum | AD | 1.70e-12 | 3.77e-01 | -0.1001 |
3635 | INPP5D | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.72e-21 | 6.10e-01 | -0.059 |
3635 | INPP5D | HTA11_866_3004761011 | Human | Colorectum | AD | 1.69e-20 | 4.99e-01 | 0.096 |
3635 | INPP5D | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.81e-06 | 3.67e-01 | 0.0451 |
3635 | INPP5D | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.40e-20 | 5.58e-01 | 0.0338 |
3635 | INPP5D | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.08e-27 | 7.17e-01 | 0.0674 |
3635 | INPP5D | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.93e-06 | 3.72e-01 | 0.0112 |
3635 | INPP5D | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.74e-17 | 3.70e-01 | 0.0588 |
3635 | INPP5D | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.68e-24 | 4.92e-01 | 0.294 |
3635 | INPP5D | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.64e-08 | 1.10e+00 | 0.3487 |
3635 | INPP5D | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.78e-12 | 3.99e-01 | 0.281 |
3635 | INPP5D | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.98e-27 | 7.16e-01 | 0.3859 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034101 | Colorectum | AD | erythrocyte homeostasis | 51/3918 | 129/18723 | 1.07e-06 | 3.59e-05 | 51 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0002262 | Colorectum | AD | myeloid cell homeostasis | 57/3918 | 157/18723 | 6.17e-06 | 1.56e-04 | 57 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0030218 | Colorectum | AD | erythrocyte differentiation | 45/3918 | 120/18723 | 2.22e-05 | 4.39e-04 | 45 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0030224 | Colorectum | AD | monocyte differentiation | 17/3918 | 36/18723 | 3.79e-04 | 4.36e-03 | 17 |
GO:0045646 | Colorectum | AD | regulation of erythrocyte differentiation | 20/3918 | 47/18723 | 6.54e-04 | 6.75e-03 | 20 |
GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
GO:0045637 | Colorectum | AD | regulation of myeloid cell differentiation | 61/3918 | 210/18723 | 3.17e-03 | 2.35e-02 | 61 |
GO:0002573 | Colorectum | AD | myeloid leukocyte differentiation | 60/3918 | 208/18723 | 4.03e-03 | 2.81e-02 | 60 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00341011 | Colorectum | SER | erythrocyte homeostasis | 39/2897 | 129/18723 | 1.70e-05 | 5.11e-04 | 39 |
GO:00022621 | Colorectum | SER | myeloid cell homeostasis | 44/2897 | 157/18723 | 4.09e-05 | 1.03e-03 | 44 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa046662 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa046663 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa046665 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa046666 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa046667 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa046668 | Colorectum | CRC | Fc gamma R-mediated phagocytosis | 27/1091 | 97/8465 | 6.24e-05 | 1.12e-03 | 7.57e-04 | 27 |
hsa046669 | Colorectum | CRC | Fc gamma R-mediated phagocytosis | 27/1091 | 97/8465 | 6.24e-05 | 1.12e-03 | 7.57e-04 | 27 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INPP5D | SNV | Missense_Mutation | c.508A>T | p.Ser170Cys | p.S170C | Q92835 | protein_coding | tolerated(0.09) | benign(0.211) | TCGA-EM-A3FR-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3635 | INPP5D | DRUGGABLE GENOME, KINASE, ENZYME, CLINICALLY ACTIONABLE | activator | 315661324 | ROSIPTOR | |
3635 | INPP5D | DRUGGABLE GENOME, KINASE, ENZYME, CLINICALLY ACTIONABLE | TURNAGAINOLIDE B | TURNAGAINOLIDE B | 21539394 | |
3635 | INPP5D | DRUGGABLE GENOME, KINASE, ENZYME, CLINICALLY ACTIONABLE | inhibitor | 336446950 | ||
3635 | INPP5D | DRUGGABLE GENOME, KINASE, ENZYME, CLINICALLY ACTIONABLE | AQX-1125 | ROSIPTOR |
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