![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: EXOC4 |
Gene summary for EXOC4 |
![]() |
Gene information | Species | Human | Gene symbol | EXOC4 | Gene ID | 60412 |
Gene name | exocyst complex component 4 | |
Gene Alias | SEC8 | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q6NX51 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60412 | EXOC4 | CCI_2 | Human | Cervix | CC | 3.60e-07 | 8.29e-01 | 0.5249 |
60412 | EXOC4 | CCI_3 | Human | Cervix | CC | 1.17e-14 | 1.30e+00 | 0.516 |
60412 | EXOC4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.59e-19 | -5.61e-01 | 0.0155 |
60412 | EXOC4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.87e-03 | -4.48e-01 | -0.1808 |
60412 | EXOC4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.22e-06 | -9.73e-01 | 0.0216 |
60412 | EXOC4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.72e-04 | 4.25e-01 | -0.1954 |
60412 | EXOC4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.10e-13 | -7.06e-01 | -0.1207 |
60412 | EXOC4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.89e-06 | -6.41e-01 | -0.2061 |
60412 | EXOC4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.35e-03 | -7.68e-01 | -0.1462 |
60412 | EXOC4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.08e-06 | -3.51e-01 | -0.0179 |
60412 | EXOC4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.50e-09 | -5.57e-01 | 0.096 |
60412 | EXOC4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.03e-02 | -4.88e-01 | 0.0528 |
60412 | EXOC4 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.56e-02 | -5.59e-01 | 0.0171 |
60412 | EXOC4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.49e-10 | -4.42e-01 | 0.0338 |
60412 | EXOC4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.90e-10 | -4.45e-01 | 0.0674 |
60412 | EXOC4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.35e-06 | -3.80e-01 | 0.294 |
60412 | EXOC4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.76e-04 | 6.58e-01 | 0.3487 |
60412 | EXOC4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.37e-14 | 9.45e-01 | 0.281 |
60412 | EXOC4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.55e-15 | -5.44e-01 | 0.3005 |
60412 | EXOC4 | A015-C-203 | Human | Colorectum | FAP | 4.12e-47 | -8.42e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:00073695 | Cervix | CC | gastrulation | 42/2311 | 185/18723 | 5.83e-05 | 8.46e-04 | 42 |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:0001704 | Cervix | CC | formation of primary germ layer | 27/2311 | 121/18723 | 1.49e-03 | 1.16e-02 | 27 |
GO:00068936 | Cervix | CC | Golgi to plasma membrane transport | 16/2311 | 60/18723 | 2.00e-03 | 1.46e-02 | 16 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:0006893 | Colorectum | AD | Golgi to plasma membrane transport | 27/3918 | 60/18723 | 2.41e-05 | 4.66e-04 | 27 |
GO:0016241 | Colorectum | AD | regulation of macroautophagy | 50/3918 | 141/18723 | 4.55e-05 | 7.92e-04 | 50 |
GO:0051648 | Colorectum | AD | vesicle localization | 59/3918 | 177/18723 | 7.83e-05 | 1.25e-03 | 59 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051322 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051323 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051325 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051326 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051327 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051328 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa051329 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa0513210 | Colorectum | CRC | Salmonella infection | 48/1091 | 249/8465 | 2.43e-03 | 1.69e-02 | 1.15e-02 | 48 |
hsa0513211 | Colorectum | CRC | Salmonella infection | 48/1091 | 249/8465 | 2.43e-03 | 1.69e-02 | 1.15e-02 | 48 |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa05132112 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0513227 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0513236 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
Page: 1 2 3 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXOC4 | SNV | Missense_Mutation | novel | c.811C>G | p.Pro271Ala | p.P271A | Q96A65 | protein_coding | tolerated(0.05) | probably_damaging(0.994) | TCGA-UF-A71A-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
EXOC4 | SNV | Missense_Mutation | novel | c.1207N>G | p.Met403Val | p.M403V | Q96A65 | protein_coding | tolerated(1) | benign(0) | TCGA-YJ-A8SW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
EXOC4 | insertion | Frame_Shift_Ins | novel | c.60dupC | p.Ser21LeufsTer14 | p.S21Lfs*14 | Q96A65 | protein_coding | TCGA-ZG-A8QW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | ||
EXOC4 | SNV | Missense_Mutation | c.440N>A | p.Ser147Asn | p.S147N | Q96A65 | protein_coding | tolerated(0.15) | possibly_damaging(0.542) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EXOC4 | SNV | Missense_Mutation | c.193C>T | p.His65Tyr | p.H65Y | Q96A65 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EXOC4 | SNV | Missense_Mutation | rs544415669 | c.716G>A | p.Arg239Gln | p.R239Q | Q96A65 | protein_coding | tolerated(0.14) | benign(0.072) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EXOC4 | SNV | Missense_Mutation | rs759701016 | c.1492G>A | p.Val498Ile | p.V498I | Q96A65 | protein_coding | tolerated(0.35) | benign(0) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EXOC4 | SNV | Missense_Mutation | c.2759N>G | p.Tyr920Cys | p.Y920C | Q96A65 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
EXOC4 | SNV | Missense_Mutation | c.436G>A | p.Ala146Thr | p.A146T | Q96A65 | protein_coding | tolerated(0.21) | probably_damaging(0.989) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EXOC4 | SNV | Missense_Mutation | c.2065A>G | p.Asn689Asp | p.N689D | Q96A65 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |