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Gene: DHX38 |
Gene summary for DHX38 |
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Gene information | Species | Human | Gene symbol | DHX38 | Gene ID | 9785 |
Gene name | DEAH-box helicase 38 | |
Gene Alias | DDX38 | |
Cytomap | 16q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q92620 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9785 | DHX38 | LZE4T | Human | Esophagus | ESCC | 2.41e-09 | 3.69e-01 | 0.0811 |
9785 | DHX38 | LZE7T | Human | Esophagus | ESCC | 1.13e-07 | 3.66e-01 | 0.0667 |
9785 | DHX38 | LZE8T | Human | Esophagus | ESCC | 5.19e-05 | 2.26e-01 | 0.067 |
9785 | DHX38 | LZE24T | Human | Esophagus | ESCC | 2.43e-08 | 2.18e-01 | 0.0596 |
9785 | DHX38 | P1T-E | Human | Esophagus | ESCC | 2.70e-07 | 5.33e-01 | 0.0875 |
9785 | DHX38 | P2T-E | Human | Esophagus | ESCC | 5.28e-14 | 1.39e-01 | 0.1177 |
9785 | DHX38 | P4T-E | Human | Esophagus | ESCC | 1.04e-08 | 1.42e-01 | 0.1323 |
9785 | DHX38 | P5T-E | Human | Esophagus | ESCC | 1.00e-12 | 1.42e-01 | 0.1327 |
9785 | DHX38 | P8T-E | Human | Esophagus | ESCC | 1.57e-17 | 2.94e-01 | 0.0889 |
9785 | DHX38 | P9T-E | Human | Esophagus | ESCC | 1.28e-09 | 1.85e-01 | 0.1131 |
9785 | DHX38 | P10T-E | Human | Esophagus | ESCC | 4.19e-17 | 1.37e-01 | 0.116 |
9785 | DHX38 | P11T-E | Human | Esophagus | ESCC | 1.05e-03 | 2.69e-01 | 0.1426 |
9785 | DHX38 | P12T-E | Human | Esophagus | ESCC | 2.06e-11 | 1.75e-01 | 0.1122 |
9785 | DHX38 | P15T-E | Human | Esophagus | ESCC | 1.14e-11 | 2.40e-01 | 0.1149 |
9785 | DHX38 | P16T-E | Human | Esophagus | ESCC | 1.84e-05 | 9.55e-02 | 0.1153 |
9785 | DHX38 | P17T-E | Human | Esophagus | ESCC | 3.54e-08 | 2.34e-01 | 0.1278 |
9785 | DHX38 | P20T-E | Human | Esophagus | ESCC | 1.76e-20 | 3.10e-01 | 0.1124 |
9785 | DHX38 | P21T-E | Human | Esophagus | ESCC | 4.27e-18 | 2.84e-01 | 0.1617 |
9785 | DHX38 | P22T-E | Human | Esophagus | ESCC | 1.40e-14 | 2.03e-01 | 0.1236 |
9785 | DHX38 | P23T-E | Human | Esophagus | ESCC | 1.65e-22 | 4.28e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DHX38 | SNV | Missense_Mutation | c.608G>A | p.Arg203Gln | p.R203Q | Q92620 | protein_coding | tolerated(0.14) | benign(0.029) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
DHX38 | SNV | Missense_Mutation | rs763111684 | c.758G>A | p.Arg253Gln | p.R253Q | Q92620 | protein_coding | tolerated(0.3) | benign(0.011) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
DHX38 | SNV | Missense_Mutation | novel | c.1549N>C | p.Ser517Arg | p.S517R | Q92620 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
DHX38 | insertion | Frame_Shift_Ins | novel | c.314_315insTTTCA | p.Lys106PhefsTer12 | p.K106Ffs*12 | Q92620 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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