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Gene: DGKB |
Gene summary for DGKB |
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Gene information | Species | Human | Gene symbol | DGKB | Gene ID | 1607 |
Gene name | diacylglycerol kinase beta | |
Gene Alias | DAGK2 | |
Cytomap | 7p21.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9Y6T7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1607 | DGKB | HCC1_Meng | Human | Liver | HCC | 3.38e-03 | -3.04e-02 | 0.0246 |
1607 | DGKB | HCC1 | Human | Liver | HCC | 1.05e-12 | 2.01e+00 | 0.5336 |
1607 | DGKB | HCC2 | Human | Liver | HCC | 4.48e-17 | 2.27e+00 | 0.5341 |
1607 | DGKB | HCC5 | Human | Liver | HCC | 4.03e-11 | 1.39e+00 | 0.4932 |
1607 | DGKB | HTA12-15-2 | Human | Pancreas | PDAC | 1.66e-14 | 9.82e-01 | 0.2315 |
1607 | DGKB | HTA12-23-1 | Human | Pancreas | PDAC | 8.00e-12 | 1.12e+00 | 0.3405 |
1607 | DGKB | HTA12-25-1 | Human | Pancreas | PDAC | 3.07e-08 | 7.26e-01 | 0.313 |
1607 | DGKB | HTA12-26-1 | Human | Pancreas | PDAC | 2.45e-25 | 1.28e+00 | 0.3728 |
1607 | DGKB | HTA12-29-1 | Human | Pancreas | PDAC | 2.25e-25 | 8.40e-01 | 0.3722 |
1607 | DGKB | HTA12-30-1 | Human | Pancreas | PDAC | 1.14e-02 | 9.73e-01 | 0.3671 |
1607 | DGKB | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 7.32e-01 | 0.3624 |
1607 | DGKB | HTA12-9-3 | Human | Pancreas | PDAC | 1.07e-02 | 5.47e-01 | 0.2045 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:003025821 | Liver | HCC | lipid modification | 123/7958 | 212/18723 | 3.50e-06 | 4.58e-05 | 123 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:00075962 | Liver | HCC | blood coagulation | 118/7958 | 217/18723 | 2.63e-04 | 1.94e-03 | 118 |
GO:00075992 | Liver | HCC | hemostasis | 119/7958 | 222/18723 | 5.25e-04 | 3.41e-03 | 119 |
GO:00508172 | Liver | HCC | coagulation | 118/7958 | 222/18723 | 8.41e-04 | 5.03e-03 | 118 |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
GO:000663911 | Liver | HCC | acylglycerol metabolic process | 72/7958 | 128/18723 | 1.16e-03 | 6.54e-03 | 72 |
GO:0006654 | Liver | HCC | phosphatidic acid biosynthetic process | 23/7958 | 33/18723 | 1.46e-03 | 7.75e-03 | 23 |
GO:000663811 | Liver | HCC | neutral lipid metabolic process | 72/7958 | 129/18723 | 1.54e-03 | 8.14e-03 | 72 |
GO:00464732 | Liver | HCC | phosphatidic acid metabolic process | 24/7958 | 37/18723 | 5.03e-03 | 2.11e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa005615 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0056112 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa0523111 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DGKB | SNV | Missense_Mutation | c.1449N>A | p.Phe483Leu | p.F483L | Q9Y6T7 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DGKB | SNV | Missense_Mutation | novel | c.2362A>G | p.Thr788Ala | p.T788A | Q9Y6T7 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DGKB | SNV | Missense_Mutation | rs186010649 | c.368C>G | p.Ser123Cys | p.S123C | Q9Y6T7 | protein_coding | tolerated(0.07) | benign(0.161) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DGKB | SNV | Missense_Mutation | novel | c.2168C>A | p.Ala723Asp | p.A723D | Q9Y6T7 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DGKB | SNV | Missense_Mutation | c.952N>A | p.Pro318Thr | p.P318T | Q9Y6T7 | protein_coding | tolerated(0.27) | benign(0.024) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DGKB | SNV | Missense_Mutation | c.1476N>T | p.Leu492Phe | p.L492F | Q9Y6T7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
DGKB | SNV | Missense_Mutation | novel | c.1991T>C | p.Ile664Thr | p.I664T | Q9Y6T7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-52-7812-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD |
DGKB | SNV | Missense_Mutation | novel | c.2402N>T | p.Arg801Leu | p.R801L | Q9Y6T7 | protein_coding | deleterious(0.01) | benign(0.02) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DGKB | SNV | Missense_Mutation | c.1208N>A | p.Ser403Tyr | p.S403Y | Q9Y6T7 | protein_coding | deleterious(0.03) | benign(0.326) | TCGA-63-A5MY-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DGKB | SNV | Missense_Mutation | c.1606N>C | p.Gly536Arg | p.G536R | Q9Y6T7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2780-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1607 | DGKB | KINASE | antipsychotics | 31447353 |
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