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Gene: DEPDC5 |
Gene summary for DEPDC5 |
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Gene information | Species | Human | Gene symbol | DEPDC5 | Gene ID | 9681 |
Gene name | DEP domain containing 5, GATOR1 subcomplex subunit | |
Gene Alias | DEP.5 | |
Cytomap | 22q12.2-q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | O75140 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9681 | DEPDC5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.02e-11 | 2.37e-01 | 0.0155 |
9681 | DEPDC5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.43e-18 | 4.98e-01 | -0.1808 |
9681 | DEPDC5 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 3.89e-01 | 0.0216 |
9681 | DEPDC5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.53e-23 | 6.33e-01 | -0.0811 |
9681 | DEPDC5 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.86e-16 | 4.36e-01 | -0.1088 |
9681 | DEPDC5 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.69e-50 | 8.41e-01 | -0.1954 |
9681 | DEPDC5 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 7.18e-01 | -0.2602 |
9681 | DEPDC5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-06 | 4.24e-01 | -0.2196 |
9681 | DEPDC5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.93e-12 | 4.18e-01 | -0.1207 |
9681 | DEPDC5 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.68e-22 | 6.66e-01 | -0.1526 |
9681 | DEPDC5 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.45e-42 | 7.89e-01 | -0.1464 |
9681 | DEPDC5 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.14e-33 | 5.83e-01 | -0.1001 |
9681 | DEPDC5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.25e-24 | 6.20e-01 | -0.059 |
9681 | DEPDC5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.52e-10 | 5.85e-01 | -0.1706 |
9681 | DEPDC5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.00e-07 | 3.82e-01 | -0.2061 |
9681 | DEPDC5 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.36e-01 | -0.1462 |
9681 | DEPDC5 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.57e-20 | 6.83e-01 | -0.0842 |
9681 | DEPDC5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.20e-07 | 4.38e-01 | -0.00410000000000005 |
9681 | DEPDC5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 3.05e-01 | -0.0179 |
9681 | DEPDC5 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.97e-15 | 3.40e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00105061 | Colorectum | SER | regulation of autophagy | 74/2897 | 317/18723 | 1.39e-04 | 2.77e-03 | 74 |
GO:00425941 | Colorectum | SER | response to starvation | 47/2897 | 197/18723 | 1.31e-03 | 1.45e-02 | 47 |
GO:00714961 | Colorectum | SER | cellular response to external stimulus | 70/2897 | 320/18723 | 1.40e-03 | 1.53e-02 | 70 |
GO:00092671 | Colorectum | SER | cellular response to starvation | 38/2897 | 156/18723 | 2.45e-03 | 2.32e-02 | 38 |
GO:00316681 | Colorectum | SER | cellular response to extracellular stimulus | 54/2897 | 246/18723 | 4.26e-03 | 3.45e-02 | 54 |
GO:00316691 | Colorectum | SER | cellular response to nutrient levels | 48/2897 | 215/18723 | 4.82e-03 | 3.78e-02 | 48 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:00425942 | Colorectum | MSS | response to starvation | 56/3467 | 197/18723 | 4.25e-04 | 5.21e-03 | 56 |
GO:00714962 | Colorectum | MSS | cellular response to external stimulus | 82/3467 | 320/18723 | 9.30e-04 | 9.44e-03 | 82 |
GO:00092672 | Colorectum | MSS | cellular response to starvation | 44/3467 | 156/18723 | 1.96e-03 | 1.69e-02 | 44 |
GO:00316692 | Colorectum | MSS | cellular response to nutrient levels | 56/3467 | 215/18723 | 3.80e-03 | 2.79e-02 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04150 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041501 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEPDC5 | SNV | Missense_Mutation | rs377718352 | c.503N>T | p.Ser168Leu | p.S168L | O75140 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | c.3026G>C | p.Gly1009Ala | p.G1009A | O75140 | protein_coding | tolerated(0.08) | benign(0.266) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DEPDC5 | SNV | Missense_Mutation | c.487N>T | p.Val163Leu | p.V163L | O75140 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-MP-A4TF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | navelbine | PD | |
DEPDC5 | SNV | Missense_Mutation | c.3007N>T | p.Asp1003Tyr | p.D1003Y | O75140 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DEPDC5 | SNV | Missense_Mutation | novel | c.4643N>T | p.Trp1548Leu | p.W1548L | O75140 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DEPDC5 | SNV | Missense_Mutation | novel | c.3821N>T | p.Pro1274Leu | p.P1274L | O75140 | protein_coding | deleterious(0) | benign(0.205) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | c.3026N>A | p.Gly1009Glu | p.G1009E | O75140 | protein_coding | tolerated(0.12) | possibly_damaging(0.559) | TCGA-37-4133-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DEPDC5 | SNV | Missense_Mutation | c.2109G>T | p.Met703Ile | p.M703I | O75140 | protein_coding | tolerated(0.47) | benign(0) | TCGA-39-5036-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DEPDC5 | SNV | Missense_Mutation | novel | c.3604N>G | p.Pro1202Ala | p.P1202A | O75140 | protein_coding | tolerated(0.35) | benign(0.015) | TCGA-43-7656-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DEPDC5 | SNV | Missense_Mutation | novel | c.3934C>G | p.Leu1312Val | p.L1312V | O75140 | protein_coding | deleterious(0.02) | benign(0.119) | TCGA-56-7580-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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