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Gene: CPSF1 |
Gene summary for CPSF1 |
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Gene information | Species | Human | Gene symbol | CPSF1 | Gene ID | 29894 |
Gene name | cleavage and polyadenylation specific factor 1 | |
Gene Alias | CPSF160 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q10570 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29894 | CPSF1 | LZE4T | Human | Esophagus | ESCC | 2.77e-03 | 8.17e-02 | 0.0811 |
29894 | CPSF1 | LZE7T | Human | Esophagus | ESCC | 2.96e-10 | 5.52e-01 | 0.0667 |
29894 | CPSF1 | LZE20T | Human | Esophagus | ESCC | 3.61e-08 | 3.56e-01 | 0.0662 |
29894 | CPSF1 | LZE24T | Human | Esophagus | ESCC | 1.39e-07 | 2.11e-01 | 0.0596 |
29894 | CPSF1 | P1T-E | Human | Esophagus | ESCC | 1.74e-14 | 4.45e-01 | 0.0875 |
29894 | CPSF1 | P2T-E | Human | Esophagus | ESCC | 2.46e-14 | 2.66e-01 | 0.1177 |
29894 | CPSF1 | P4T-E | Human | Esophagus | ESCC | 1.35e-10 | 1.55e-01 | 0.1323 |
29894 | CPSF1 | P5T-E | Human | Esophagus | ESCC | 4.06e-12 | 1.57e-01 | 0.1327 |
29894 | CPSF1 | P8T-E | Human | Esophagus | ESCC | 3.21e-10 | 1.95e-01 | 0.0889 |
29894 | CPSF1 | P9T-E | Human | Esophagus | ESCC | 2.87e-09 | 1.41e-01 | 0.1131 |
29894 | CPSF1 | P10T-E | Human | Esophagus | ESCC | 5.83e-10 | 1.50e-01 | 0.116 |
29894 | CPSF1 | P11T-E | Human | Esophagus | ESCC | 4.28e-07 | 3.73e-01 | 0.1426 |
29894 | CPSF1 | P12T-E | Human | Esophagus | ESCC | 8.29e-24 | 4.17e-01 | 0.1122 |
29894 | CPSF1 | P15T-E | Human | Esophagus | ESCC | 1.52e-20 | 4.50e-01 | 0.1149 |
29894 | CPSF1 | P16T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.06e-01 | 0.1153 |
29894 | CPSF1 | P17T-E | Human | Esophagus | ESCC | 3.21e-08 | 3.75e-01 | 0.1278 |
29894 | CPSF1 | P20T-E | Human | Esophagus | ESCC | 5.00e-16 | 1.99e-01 | 0.1124 |
29894 | CPSF1 | P21T-E | Human | Esophagus | ESCC | 2.92e-20 | 3.39e-01 | 0.1617 |
29894 | CPSF1 | P22T-E | Human | Esophagus | ESCC | 1.27e-12 | 1.92e-01 | 0.1236 |
29894 | CPSF1 | P23T-E | Human | Esophagus | ESCC | 4.37e-16 | 3.69e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:003112412 | Esophagus | ESCC | mRNA 3'-end processing | 47/8552 | 62/18723 | 1.29e-06 | 1.58e-05 | 47 |
GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:00063783 | Esophagus | ESCC | mRNA polyadenylation | 33/8552 | 44/18723 | 7.30e-05 | 5.49e-04 | 33 |
GO:00436313 | Esophagus | ESCC | RNA polyadenylation | 33/8552 | 45/18723 | 1.54e-04 | 1.02e-03 | 33 |
GO:00063793 | Esophagus | ESCC | mRNA cleavage | 17/8552 | 22/18723 | 2.60e-03 | 1.11e-02 | 17 |
GO:00987872 | Esophagus | ESCC | mRNA cleavage involved in mRNA processing | 11/8552 | 14/18723 | 1.30e-02 | 4.27e-02 | 11 |
GO:00311241 | Liver | HCC | mRNA 3'-end processing | 50/7958 | 62/18723 | 8.44e-10 | 2.60e-08 | 50 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00311231 | Liver | HCC | RNA 3'-end processing | 81/7958 | 116/18723 | 2.27e-09 | 6.32e-08 | 81 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0006378 | Liver | HCC | mRNA polyadenylation | 35/7958 | 44/18723 | 5.70e-07 | 9.03e-06 | 35 |
GO:0043631 | Liver | HCC | RNA polyadenylation | 35/7958 | 45/18723 | 1.51e-06 | 2.15e-05 | 35 |
GO:0006379 | Liver | HCC | mRNA cleavage | 17/7958 | 22/18723 | 9.84e-04 | 5.70e-03 | 17 |
GO:0098789 | Liver | HCC | pre-mRNA cleavage required for polyadenylation | 11/7958 | 13/18723 | 2.38e-03 | 1.16e-02 | 11 |
GO:0098787 | Liver | HCC | mRNA cleavage involved in mRNA processing | 11/7958 | 14/18723 | 6.81e-03 | 2.73e-02 | 11 |
GO:00311242 | Oral cavity | OSCC | mRNA 3'-end processing | 49/7305 | 62/18723 | 1.40e-10 | 4.14e-09 | 49 |
GO:00905012 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis | 95/7305 | 152/18723 | 3.65e-09 | 8.22e-08 | 95 |
GO:00311232 | Oral cavity | OSCC | RNA 3'-end processing | 75/7305 | 116/18723 | 1.93e-08 | 3.79e-07 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0301521 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa0301531 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa030158 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0301513 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPSF1 | SNV | Missense_Mutation | novel | c.1763C>T | p.Thr588Met | p.T588M | Q10570 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CPSF1 | SNV | Missense_Mutation | novel | c.2816N>T | p.Gly939Val | p.G939V | Q10570 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPSF1 | SNV | Missense_Mutation | novel | c.1735C>T | p.Arg579Trp | p.R579W | Q10570 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPSF1 | SNV | Missense_Mutation | novel | c.1483N>A | p.Glu495Lys | p.E495K | Q10570 | protein_coding | tolerated(0.05) | possibly_damaging(0.459) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CPSF1 | SNV | Missense_Mutation | novel | c.1279N>G | p.Thr427Ala | p.T427A | Q10570 | protein_coding | tolerated(0.89) | benign(0.009) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
CPSF1 | SNV | Missense_Mutation | rs141624286 | c.3767A>G | p.Tyr1256Cys | p.Y1256C | Q10570 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
CPSF1 | SNV | Missense_Mutation | novel | c.1880G>A | p.Arg627His | p.R627H | Q10570 | protein_coding | deleterious(0.05) | probably_damaging(0.994) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
CPSF1 | SNV | Missense_Mutation | rs781806525 | c.3821N>A | p.Arg1274His | p.R1274H | Q10570 | protein_coding | tolerated(0.24) | benign(0.159) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CPSF1 | SNV | Missense_Mutation | novel | c.407N>C | p.Val136Ala | p.V136A | Q10570 | protein_coding | tolerated(0.48) | benign(0.089) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CPSF1 | SNV | Missense_Mutation | rs145778551 | c.1298N>T | p.Ala433Val | p.A433V | Q10570 | protein_coding | tolerated(0.21) | benign(0.051) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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