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Gene: CNGB1 |
Gene summary for CNGB1 |
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Gene information | Species | Human | Gene symbol | CNGB1 | Gene ID | 1258 |
Gene name | cyclic nucleotide gated channel subunit beta 1 | |
Gene Alias | CNCG2 | |
Cytomap | 16q21 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q14028 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1258 | CNGB1 | C04 | Human | Oral cavity | OSCC | 2.02e-04 | 2.00e-01 | 0.2633 |
1258 | CNGB1 | C21 | Human | Oral cavity | OSCC | 8.63e-03 | 1.16e-01 | 0.2678 |
1258 | CNGB1 | C51 | Human | Oral cavity | OSCC | 3.74e-18 | 6.08e-01 | 0.2674 |
1258 | CNGB1 | C06 | Human | Oral cavity | OSCC | 5.31e-08 | 1.03e+00 | 0.2699 |
1258 | CNGB1 | C09 | Human | Oral cavity | OSCC | 1.83e-17 | 4.24e-01 | 0.1431 |
1258 | CNGB1 | SYSMH3 | Human | Oral cavity | OSCC | 4.88e-03 | 1.59e-01 | 0.2442 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNGB1 | SNV | Missense_Mutation | novel | c.3535G>T | p.Ala1179Ser | p.A1179S | Q14028 | protein_coding | tolerated(0.42) | benign(0) | TCGA-85-8479-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CNGB1 | deletion | Frame_Shift_Del | c.1047delN | p.Ile350LeufsTer23 | p.I350Lfs*23 | Q14028 | protein_coding | TCGA-55-8615-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |||
CNGB1 | SNV | Missense_Mutation | novel | c.3133A>T | p.Asn1045Tyr | p.N1045Y | Q14028 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CNGB1 | SNV | Missense_Mutation | novel | c.790N>C | p.Glu264Gln | p.E264Q | Q14028 | protein_coding | deleterious_low_confidence(0.05) | benign(0.063) | TCGA-BB-8596-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CNGB1 | SNV | Missense_Mutation | rs768874859 | c.1676C>A | p.Thr559Lys | p.T559K | Q14028 | protein_coding | deleterious(0.03) | benign(0.079) | TCGA-CN-6012-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
CNGB1 | SNV | Missense_Mutation | novel | c.575N>T | p.Ser192Leu | p.S192L | Q14028 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-CN-6013-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CNGB1 | SNV | Missense_Mutation | rs762365839 | c.1721N>C | p.Leu574Pro | p.L574P | Q14028 | protein_coding | deleterious(0.01) | possibly_damaging(0.885) | TCGA-CR-7382-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
CNGB1 | SNV | Missense_Mutation | novel | c.94N>C | p.Glu32Gln | p.E32Q | Q14028 | protein_coding | tolerated_low_confidence(0.1) | possibly_damaging(0.601) | TCGA-CV-5970-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CNGB1 | SNV | Missense_Mutation | novel | c.1348N>A | p.Glu450Lys | p.E450K | Q14028 | protein_coding | tolerated(0.48) | benign(0.036) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
CNGB1 | SNV | Missense_Mutation | novel | c.1336G>A | p.Glu446Lys | p.E446K | Q14028 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-CV-A45Q-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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