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Gene: CLSPN |
Gene summary for CLSPN |
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Gene information | Species | Human | Gene symbol | CLSPN | Gene ID | 63967 |
Gene name | claspin | |
Gene Alias | CLSPN | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9HAW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63967 | CLSPN | LZE7T | Human | Esophagus | ESCC | 6.13e-07 | 4.59e-01 | 0.0667 |
63967 | CLSPN | LZE6T | Human | Esophagus | ESCC | 5.35e-04 | 2.02e-01 | 0.0845 |
63967 | CLSPN | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 3.11e-01 | 0.0875 |
63967 | CLSPN | P2T-E | Human | Esophagus | ESCC | 2.68e-08 | 4.30e-01 | 0.1177 |
63967 | CLSPN | P4T-E | Human | Esophagus | ESCC | 6.14e-11 | 2.89e-01 | 0.1323 |
63967 | CLSPN | P5T-E | Human | Esophagus | ESCC | 1.29e-11 | 3.60e-01 | 0.1327 |
63967 | CLSPN | P10T-E | Human | Esophagus | ESCC | 1.29e-06 | 2.62e-01 | 0.116 |
63967 | CLSPN | P12T-E | Human | Esophagus | ESCC | 1.31e-03 | 1.52e-01 | 0.1122 |
63967 | CLSPN | P15T-E | Human | Esophagus | ESCC | 3.34e-06 | 2.01e-01 | 0.1149 |
63967 | CLSPN | P17T-E | Human | Esophagus | ESCC | 2.14e-09 | 3.71e-01 | 0.1278 |
63967 | CLSPN | P21T-E | Human | Esophagus | ESCC | 1.16e-05 | 3.67e-01 | 0.1617 |
63967 | CLSPN | P22T-E | Human | Esophagus | ESCC | 9.54e-05 | 1.47e-01 | 0.1236 |
63967 | CLSPN | P23T-E | Human | Esophagus | ESCC | 3.36e-03 | 1.47e-01 | 0.108 |
63967 | CLSPN | P24T-E | Human | Esophagus | ESCC | 2.89e-04 | 1.57e-01 | 0.1287 |
63967 | CLSPN | P26T-E | Human | Esophagus | ESCC | 1.48e-03 | 1.21e-01 | 0.1276 |
63967 | CLSPN | P27T-E | Human | Esophagus | ESCC | 2.04e-06 | 2.46e-01 | 0.1055 |
63967 | CLSPN | P28T-E | Human | Esophagus | ESCC | 1.29e-12 | 3.49e-01 | 0.1149 |
63967 | CLSPN | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 3.78e-01 | 0.137 |
63967 | CLSPN | P31T-E | Human | Esophagus | ESCC | 1.92e-17 | 5.34e-01 | 0.1251 |
63967 | CLSPN | P32T-E | Human | Esophagus | ESCC | 7.37e-19 | 5.02e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:00448394 | Esophagus | ESCC | cell cycle G2/M phase transition | 103/8552 | 148/18723 | 3.09e-09 | 6.67e-08 | 103 |
GO:00000864 | Esophagus | ESCC | G2/M transition of mitotic cell cycle | 96/8552 | 137/18723 | 6.00e-09 | 1.23e-07 | 96 |
GO:00070934 | Esophagus | ESCC | mitotic cell cycle checkpoint | 90/8552 | 129/18723 | 2.49e-08 | 4.69e-07 | 90 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:00000775 | Esophagus | ESCC | DNA damage checkpoint | 78/8552 | 115/18723 | 1.27e-06 | 1.56e-05 | 78 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:004593013 | Esophagus | ESCC | negative regulation of mitotic cell cycle | 143/8552 | 235/18723 | 1.84e-06 | 2.15e-05 | 143 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:190199113 | Esophagus | ESCC | negative regulation of mitotic cell cycle phase transition | 112/8552 | 179/18723 | 3.69e-06 | 4.03e-05 | 112 |
GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLSPN | SNV | Missense_Mutation | novel | c.928N>C | p.Glu310Gln | p.E310Q | Q9HAW4 | protein_coding | deleterious(0.02) | possibly_damaging(0.776) | TCGA-BB-4223-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
CLSPN | SNV | Missense_Mutation | rs747801015 | c.2861C>T | p.Ser954Phe | p.S954F | Q9HAW4 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-C9-A47Z-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CLSPN | SNV | Missense_Mutation | novel | c.758N>T | p.Ser253Phe | p.S253F | Q9HAW4 | protein_coding | tolerated(0.31) | benign(0.055) | TCGA-CN-4734-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLSPN | SNV | Missense_Mutation | novel | c.770N>T | p.Gly257Val | p.G257V | Q9HAW4 | protein_coding | tolerated(0.25) | possibly_damaging(0.9) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CLSPN | insertion | Frame_Shift_Ins | novel | c.1211_1212insA | p.Asn404LysfsTer2 | p.N404Kfs*2 | Q9HAW4 | protein_coding | TCGA-CV-7250-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
CLSPN | SNV | Missense_Mutation | rs114727604 | c.1090N>A | p.Gly364Ser | p.G364S | Q9HAW4 | protein_coding | tolerated(0.25) | benign(0.074) | TCGA-EJ-A46F-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | PD |
CLSPN | SNV | Missense_Mutation | novel | c.1655N>T | p.Asn552Ile | p.N552I | Q9HAW4 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-B7-A5TJ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CLSPN | SNV | Missense_Mutation | novel | c.2454N>T | p.Leu818Phe | p.L818F | Q9HAW4 | protein_coding | tolerated(1) | benign(0.047) | TCGA-BR-8284-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CLSPN | SNV | Missense_Mutation | c.548N>A | p.Ile183Asn | p.I183N | Q9HAW4 | protein_coding | deleterious(0.01) | probably_damaging(0.93) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CLSPN | SNV | Missense_Mutation | c.3859N>G | p.Thr1287Ala | p.T1287A | Q9HAW4 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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