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Gene: CKAP5 |
Gene summary for CKAP5 |
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Gene information | Species | Human | Gene symbol | CKAP5 | Gene ID | 9793 |
Gene name | cytoskeleton associated protein 5 | |
Gene Alias | CHTOG | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q14008 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9793 | CKAP5 | LZE2T | Human | Esophagus | ESCC | 5.05e-04 | 8.41e-01 | 0.082 |
9793 | CKAP5 | LZE4T | Human | Esophagus | ESCC | 2.12e-13 | 3.88e-01 | 0.0811 |
9793 | CKAP5 | LZE5T | Human | Esophagus | ESCC | 1.76e-03 | 3.10e-01 | 0.0514 |
9793 | CKAP5 | LZE7T | Human | Esophagus | ESCC | 3.52e-17 | 6.46e-01 | 0.0667 |
9793 | CKAP5 | LZE8T | Human | Esophagus | ESCC | 1.40e-10 | 2.54e-01 | 0.067 |
9793 | CKAP5 | LZE24T | Human | Esophagus | ESCC | 1.39e-12 | 3.74e-01 | 0.0596 |
9793 | CKAP5 | LZE6T | Human | Esophagus | ESCC | 3.95e-03 | 3.44e-01 | 0.0845 |
9793 | CKAP5 | P1T-E | Human | Esophagus | ESCC | 4.90e-04 | 2.25e-01 | 0.0875 |
9793 | CKAP5 | P2T-E | Human | Esophagus | ESCC | 1.92e-34 | 5.98e-01 | 0.1177 |
9793 | CKAP5 | P4T-E | Human | Esophagus | ESCC | 5.96e-12 | 4.55e-01 | 0.1323 |
9793 | CKAP5 | P5T-E | Human | Esophagus | ESCC | 3.43e-13 | 2.53e-01 | 0.1327 |
9793 | CKAP5 | P8T-E | Human | Esophagus | ESCC | 1.57e-18 | 3.56e-01 | 0.0889 |
9793 | CKAP5 | P9T-E | Human | Esophagus | ESCC | 4.56e-16 | 3.21e-01 | 0.1131 |
9793 | CKAP5 | P10T-E | Human | Esophagus | ESCC | 5.25e-19 | 3.65e-01 | 0.116 |
9793 | CKAP5 | P11T-E | Human | Esophagus | ESCC | 1.70e-05 | 3.75e-01 | 0.1426 |
9793 | CKAP5 | P12T-E | Human | Esophagus | ESCC | 2.00e-15 | 3.26e-01 | 0.1122 |
9793 | CKAP5 | P15T-E | Human | Esophagus | ESCC | 2.72e-12 | 4.51e-01 | 0.1149 |
9793 | CKAP5 | P16T-E | Human | Esophagus | ESCC | 6.18e-23 | 3.50e-01 | 0.1153 |
9793 | CKAP5 | P17T-E | Human | Esophagus | ESCC | 5.37e-11 | 5.93e-01 | 0.1278 |
9793 | CKAP5 | P20T-E | Human | Esophagus | ESCC | 4.60e-17 | 4.11e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0043624 | Colorectum | AD | cellular protein complex disassembly | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0051261 | Colorectum | AD | protein depolymerization | 39/3918 | 114/18723 | 6.74e-04 | 6.91e-03 | 39 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00512611 | Colorectum | SER | protein depolymerization | 31/2897 | 114/18723 | 9.18e-04 | 1.11e-02 | 31 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00329843 | Colorectum | MSI-H | protein-containing complex disassembly | 28/1319 | 224/18723 | 2.24e-03 | 3.01e-02 | 28 |
GO:00224113 | Colorectum | MSI-H | cellular component disassembly | 47/1319 | 443/18723 | 3.26e-03 | 3.99e-02 | 47 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
GO:00329844 | Colorectum | FAP | protein-containing complex disassembly | 54/2622 | 224/18723 | 3.37e-05 | 7.48e-04 | 54 |
GO:00512612 | Colorectum | FAP | protein depolymerization | 26/2622 | 114/18723 | 7.36e-03 | 4.40e-02 | 26 |
GO:00329845 | Colorectum | CRC | protein-containing complex disassembly | 46/2078 | 224/18723 | 2.61e-05 | 7.18e-04 | 46 |
GO:00224115 | Colorectum | CRC | cellular component disassembly | 75/2078 | 443/18723 | 1.26e-04 | 2.42e-03 | 75 |
GO:00512613 | Colorectum | CRC | protein depolymerization | 22/2078 | 114/18723 | 6.73e-03 | 4.77e-02 | 22 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CKAP5 | insertion | Frame_Shift_Ins | novel | c.876_877insA | p.Trp293MetfsTer94 | p.W293Mfs*94 | Q14008 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
CKAP5 | insertion | Frame_Shift_Ins | novel | c.1670dupA | p.Lys559GlufsTer22 | p.K559Efs*22 | Q14008 | protein_coding | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CKAP5 | SNV | Missense_Mutation | c.2224N>A | p.Ala742Thr | p.A742T | Q14008 | protein_coding | deleterious(0) | benign(0.043) | TCGA-DD-A1EF-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CKAP5 | SNV | Missense_Mutation | novel | c.1301A>T | p.Lys434Met | p.K434M | Q14008 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-DD-AACL-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CKAP5 | SNV | Missense_Mutation | novel | c.5573A>G | p.Lys1858Arg | p.K1858R | Q14008 | protein_coding | tolerated(0.54) | benign(0.039) | TCGA-DD-AADG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CKAP5 | SNV | Missense_Mutation | c.1621N>A | p.Gly541Arg | p.G541R | Q14008 | protein_coding | tolerated(0.06) | possibly_damaging(0.642) | TCGA-G3-A5SM-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CKAP5 | SNV | Missense_Mutation | novel | c.1603N>G | p.Ile535Val | p.I535V | Q14008 | protein_coding | tolerated(0.42) | benign(0) | TCGA-LG-A9QD-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | sorafenib | SD |
CKAP5 | SNV | Missense_Mutation | novel | c.3457N>C | p.Asp1153His | p.D1153H | Q14008 | protein_coding | deleterious(0) | possibly_damaging(0.868) | TCGA-44-6777-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CKAP5 | SNV | Missense_Mutation | c.3917N>T | p.Arg1306Leu | p.R1306L | Q14008 | protein_coding | deleterious(0) | possibly_damaging(0.733) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CKAP5 | SNV | Missense_Mutation | novel | c.4361N>T | p.Lys1454Met | p.K1454M | Q14008 | protein_coding | deleterious(0.01) | possibly_damaging(0.72) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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