![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BNC2 |
Gene summary for BNC2 |
![]() |
Gene information | Species | Human | Gene symbol | BNC2 | Gene ID | 54796 |
Gene name | basonuclin 2 | |
Gene Alias | BSN2 | |
Cytomap | 9p22.3-p22.2 | |
Gene Type | protein-coding | GO ID | GO:0003416 | UniProtAcc | Q5H9S4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54796 | BNC2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.93e-17 | 9.80e-01 | -0.059 |
54796 | BNC2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.13e-02 | 6.01e-01 | 0.0131 |
54796 | BNC2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.07e-02 | 3.99e-01 | 0.0338 |
54796 | BNC2 | A002-C-010 | Human | Colorectum | FAP | 4.84e-03 | 3.51e-01 | 0.242 |
54796 | BNC2 | A015-C-202 | Human | Colorectum | FAP | 1.51e-02 | 2.65e-01 | -0.0849 |
54796 | BNC2 | A008-E-015 | Human | Colorectum | FAP | 1.45e-03 | 3.45e-01 | 0.0177 |
54796 | BNC2 | P2T-E | Human | Esophagus | ESCC | 1.00e-30 | 5.97e-01 | 0.1177 |
54796 | BNC2 | P9T-E | Human | Esophagus | ESCC | 1.45e-04 | 2.20e-01 | 0.1131 |
54796 | BNC2 | P10T-E | Human | Esophagus | ESCC | 9.24e-68 | 1.25e+00 | 0.116 |
54796 | BNC2 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 1.71e-01 | 0.1175 |
54796 | BNC2 | P44T-E | Human | Esophagus | ESCC | 2.47e-02 | 1.24e-01 | 0.1096 |
54796 | BNC2 | P1_S1_AK | Human | Skin | AK | 5.74e-28 | 8.36e-01 | -0.3399 |
54796 | BNC2 | P2_S3_AK | Human | Skin | AK | 8.68e-30 | 7.79e-01 | -0.3287 |
54796 | BNC2 | P2_S4_SCCIS | Human | Skin | SCCIS | 1.08e-16 | 5.78e-01 | -0.3043 |
54796 | BNC2 | P3_S6_AK | Human | Skin | AK | 7.19e-18 | 6.03e-01 | -0.3256 |
54796 | BNC2 | P4_S8_cSCC | Human | Skin | cSCC | 1.46e-02 | 1.71e-01 | -0.3095 |
54796 | BNC2 | P2_cSCC | Human | Skin | cSCC | 5.92e-09 | 3.91e-01 | -0.024 |
54796 | BNC2 | PTC01 | Human | Thyroid | PTC | 5.49e-07 | 2.22e-01 | 0.1899 |
54796 | BNC2 | PTC06 | Human | Thyroid | PTC | 4.08e-09 | 3.51e-01 | 0.2057 |
54796 | BNC2 | PTC07 | Human | Thyroid | PTC | 2.31e-12 | 2.78e-01 | 0.2044 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060485 | Colorectum | FAP | mesenchyme development | 59/2622 | 291/18723 | 1.94e-03 | 1.64e-02 | 59 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:0003416 | Esophagus | ESCC | endochondral bone growth | 19/8552 | 26/18723 | 4.31e-03 | 1.71e-02 | 19 |
GO:0060021 | Esophagus | ESCC | roof of mouth development | 50/8552 | 85/18723 | 1.00e-02 | 3.42e-02 | 50 |
GO:00604857 | Skin | AK | mesenchyme development | 48/1910 | 291/18723 | 5.64e-04 | 5.06e-03 | 48 |
GO:00352653 | Skin | AK | organ growth | 29/1910 | 178/18723 | 7.57e-03 | 3.86e-02 | 29 |
GO:003526512 | Skin | SCCIS | organ growth | 17/919 | 178/18723 | 6.73e-03 | 4.96e-02 | 17 |
GO:006048514 | Thyroid | PTC | mesenchyme development | 112/5968 | 291/18723 | 9.48e-03 | 3.90e-02 | 112 |
GO:006048521 | Thyroid | ATC | mesenchyme development | 136/6293 | 291/18723 | 2.04e-06 | 2.43e-05 | 136 |
GO:00600211 | Thyroid | ATC | roof of mouth development | 42/6293 | 85/18723 | 1.83e-03 | 9.02e-03 | 42 |
GO:00352654 | Thyroid | ATC | organ growth | 77/6293 | 178/18723 | 4.45e-03 | 1.85e-02 | 77 |
GO:00034161 | Thyroid | ATC | endochondral bone growth | 15/6293 | 26/18723 | 9.95e-03 | 3.63e-02 | 15 |
GO:0098868 | Thyroid | ATC | bone growth | 16/6293 | 29/18723 | 1.37e-02 | 4.77e-02 | 16 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BNC2 | SNV | Missense_Mutation | rs780058802 | c.550G>A | p.Val184Met | p.V184M | Q6ZN30 | protein_coding | deleterious(0) | possibly_damaging(0.598) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BNC2 | SNV | Missense_Mutation | novel | c.389A>C | p.Asn130Thr | p.N130T | Q6ZN30 | protein_coding | deleterious(0.01) | benign(0.143) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BNC2 | SNV | Missense_Mutation | rs201719018 | c.2941N>A | p.Asp981Asn | p.D981N | Q6ZN30 | protein_coding | deleterious(0) | possibly_damaging(0.569) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BNC2 | SNV | Missense_Mutation | novel | c.610N>T | p.His204Tyr | p.H204Y | Q6ZN30 | protein_coding | deleterious(0) | possibly_damaging(0.633) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BNC2 | SNV | Missense_Mutation | rs752799809 | c.3005N>T | p.Ser1002Leu | p.S1002L | Q6ZN30 | protein_coding | tolerated(0.13) | benign(0.019) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BNC2 | SNV | Missense_Mutation | rs752429719 | c.452N>T | p.Thr151Met | p.T151M | Q6ZN30 | protein_coding | tolerated(0.07) | benign(0.401) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BNC2 | SNV | Missense_Mutation | rs752551063 | c.2708N>T | p.Ser903Leu | p.S903L | Q6ZN30 | protein_coding | tolerated(0.65) | benign(0.027) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
BNC2 | SNV | Missense_Mutation | c.1462N>T | p.Arg488Cys | p.R488C | Q6ZN30 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
BNC2 | SNV | Missense_Mutation | novel | c.734N>C | p.Leu245Pro | p.L245P | Q6ZN30 | protein_coding | deleterious(0) | possibly_damaging(0.467) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
BNC2 | SNV | Missense_Mutation | novel | c.2483C>A | p.Ser828Tyr | p.S828Y | Q6ZN30 | protein_coding | tolerated(0.6) | probably_damaging(0.99) | TCGA-PG-A917-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |