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Gene: ATP2B4 |
Gene summary for ATP2B4 |
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Gene information | Species | Human | Gene symbol | ATP2B4 | Gene ID | 493 |
Gene name | ATPase plasma membrane Ca2+ transporting 4 | |
Gene Alias | ATP2B2 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P23634 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
493 | ATP2B4 | CA_HPV_3 | Human | Cervix | CC | 8.73e-03 | 1.06e-01 | 0.0414 |
493 | ATP2B4 | CCI_1 | Human | Cervix | CC | 9.10e-11 | 1.25e+00 | 0.528 |
493 | ATP2B4 | CCI_2 | Human | Cervix | CC | 9.36e-05 | 6.87e-01 | 0.5249 |
493 | ATP2B4 | CCI_3 | Human | Cervix | CC | 3.77e-18 | 1.09e+00 | 0.516 |
493 | ATP2B4 | sample3 | Human | Cervix | CC | 5.05e-06 | 2.51e-01 | 0.1387 |
493 | ATP2B4 | T3 | Human | Cervix | CC | 4.11e-02 | 2.10e-01 | 0.1389 |
493 | ATP2B4 | LZE2D | Human | Esophagus | HGIN | 3.16e-03 | 3.68e-01 | 0.0642 |
493 | ATP2B4 | LZE2T | Human | Esophagus | ESCC | 1.96e-03 | 6.19e-01 | 0.082 |
493 | ATP2B4 | LZE4T | Human | Esophagus | ESCC | 2.68e-17 | 5.77e-01 | 0.0811 |
493 | ATP2B4 | LZE7T | Human | Esophagus | ESCC | 7.24e-12 | 6.07e-01 | 0.0667 |
493 | ATP2B4 | LZE8T | Human | Esophagus | ESCC | 1.59e-04 | 3.16e-01 | 0.067 |
493 | ATP2B4 | LZE20T | Human | Esophagus | ESCC | 2.09e-03 | 3.46e-01 | 0.0662 |
493 | ATP2B4 | LZE24T | Human | Esophagus | ESCC | 1.41e-10 | 3.09e-01 | 0.0596 |
493 | ATP2B4 | LZE21T | Human | Esophagus | ESCC | 1.26e-09 | 1.09e+00 | 0.0655 |
493 | ATP2B4 | P1T-E | Human | Esophagus | ESCC | 6.74e-05 | 4.08e-01 | 0.0875 |
493 | ATP2B4 | P2T-E | Human | Esophagus | ESCC | 2.03e-30 | 6.00e-01 | 0.1177 |
493 | ATP2B4 | P4T-E | Human | Esophagus | ESCC | 8.46e-24 | 6.64e-01 | 0.1323 |
493 | ATP2B4 | P5T-E | Human | Esophagus | ESCC | 2.18e-50 | 1.11e+00 | 0.1327 |
493 | ATP2B4 | P8T-E | Human | Esophagus | ESCC | 2.72e-16 | 2.63e-01 | 0.0889 |
493 | ATP2B4 | P9T-E | Human | Esophagus | ESCC | 7.13e-11 | 3.88e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:19043779 | Cervix | CC | positive regulation of protein localization to cell periphery | 24/2311 | 69/18723 | 1.21e-06 | 4.15e-05 | 24 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:19030788 | Cervix | CC | positive regulation of protein localization to plasma membrane | 21/2311 | 62/18723 | 8.91e-06 | 2.03e-04 | 21 |
GO:00435427 | Cervix | CC | endothelial cell migration | 60/2311 | 279/18723 | 1.05e-05 | 2.33e-04 | 60 |
GO:19028062 | Cervix | CC | regulation of cell cycle G1/S phase transition | 41/2311 | 168/18723 | 1.18e-05 | 2.51e-04 | 41 |
GO:00105944 | Cervix | CC | regulation of endothelial cell migration | 52/2311 | 232/18723 | 1.20e-05 | 2.54e-04 | 52 |
GO:00448434 | Cervix | CC | cell cycle G1/S phase transition | 53/2311 | 241/18723 | 1.76e-05 | 3.32e-04 | 53 |
GO:00719025 | Cervix | CC | positive regulation of protein serine/threonine kinase activity | 46/2311 | 200/18723 | 1.87e-05 | 3.47e-04 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040224 | Oral cavity | EOLP | cGMP-PKG signaling pathway | 36/1218 | 167/8465 | 7.34e-03 | 2.12e-02 | 1.25e-02 | 36 |
hsa0402211 | Oral cavity | EOLP | cGMP-PKG signaling pathway | 36/1218 | 167/8465 | 7.34e-03 | 2.12e-02 | 1.25e-02 | 36 |
hsa0402221 | Oral cavity | NEOLP | cGMP-PKG signaling pathway | 35/1112 | 167/8465 | 3.02e-03 | 1.25e-02 | 7.85e-03 | 35 |
hsa0402231 | Oral cavity | NEOLP | cGMP-PKG signaling pathway | 35/1112 | 167/8465 | 3.02e-03 | 1.25e-02 | 7.85e-03 | 35 |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0496112 | Prostate | BPH | Endocrine and other factor-regulated calcium reabsorption | 18/1718 | 53/8465 | 1.39e-02 | 4.05e-02 | 2.51e-02 | 18 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0496113 | Prostate | BPH | Endocrine and other factor-regulated calcium reabsorption | 18/1718 | 53/8465 | 1.39e-02 | 4.05e-02 | 2.51e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP2B4 | insertion | Frame_Shift_Ins | novel | c.2679_2680insC | p.Thr896TyrfsTer14 | p.T896Yfs*14 | P23634 | protein_coding | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | ||
ATP2B4 | SNV | Missense_Mutation | rs530220412 | c.1918A>G | p.Ile640Val | p.I640V | P23634 | protein_coding | tolerated(0.44) | benign(0.014) | TCGA-J8-A3O1-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP2B4 | SNV | Missense_Mutation | novel | c.933N>G | p.Asn311Lys | p.N311K | P23634 | protein_coding | tolerated(0.29) | benign(0.012) | TCGA-L6-A4EQ-01 | Thyroid | thyroid carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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