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Gene: ARMC3 |
Gene summary for ARMC3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ARMC3 | Gene ID | 219681 |
Gene name | armadillo repeat containing 3 | |
Gene Alias | CT81 | |
Cytomap | 10p12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5W041 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219681 | ARMC3 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 7.47e-01 | -0.0238 |
219681 | ARMC3 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 6.53e-01 | -0.0186 |
219681 | ARMC3 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 7.14e-01 | -0.0296 |
219681 | ARMC3 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 7.21e-01 | -0.0263 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Lung | AAH: Atypical adenomatous hyperplasia | |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMC3 | SNV | Missense_Mutation | c.2267G>A | p.Gly756Asp | p.G756D | Q5W041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4366-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | c.197T>G | p.Leu66Arg | p.L66R | Q5W041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR | |
ARMC3 | SNV | Missense_Mutation | c.164N>C | p.Lys55Thr | p.K55T | Q5W041 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMC3 | SNV | Missense_Mutation | rs763504461 | c.1294N>T | p.Arg432Cys | p.R432C | Q5W041 | protein_coding | deleterious(0.01) | possibly_damaging(0.609) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
ARMC3 | SNV | Missense_Mutation | c.1637A>C | p.Lys546Thr | p.K546T | Q5W041 | protein_coding | tolerated(0.15) | possibly_damaging(0.621) | TCGA-D7-6818-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
ARMC3 | SNV | Missense_Mutation | rs199547387 | c.1346N>A | p.Arg449His | p.R449H | Q5W041 | protein_coding | tolerated(0.37) | benign(0) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | novel | c.524N>T | p.Tyr175Phe | p.Y175F | Q5W041 | protein_coding | tolerated(0.27) | benign(0.25) | TCGA-IN-A6RL-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ARMC3 | SNV | Missense_Mutation | novel | c.668A>T | p.Glu223Val | p.E223V | Q5W041 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ARMC3 | SNV | Missense_Mutation | c.2449C>T | p.Arg817Cys | p.R817C | Q5W041 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
ARMC3 | SNV | Missense_Mutation | novel | c.865N>T | p.Pro289Ser | p.P289S | Q5W041 | protein_coding | deleterious(0.03) | possibly_damaging(0.774) | TCGA-VQ-A8P5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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