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Gene: AIM1 |
Gene summary for AIM1 |
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Gene information | Species | Human | Gene symbol | AIM1 | Gene ID | 9212 |
Gene name | aurora kinase B | |
Gene Alias | AIK2 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000022 | UniProtAcc | Q96GD4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9212 | AIM1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.29e-72 | 1.30e+00 | 0.294 |
9212 | AIM1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.60e-16 | 1.29e+00 | 0.3487 |
9212 | AIM1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.91e-54 | 1.92e+00 | 0.281 |
9212 | AIM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.54e-31 | 6.60e-01 | 0.3859 |
9212 | AIM1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.78e-27 | 8.17e-01 | 0.2585 |
9212 | AIM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.28e-34 | 6.47e-01 | 0.3005 |
9212 | AIM1 | P1T-E | Human | Esophagus | ESCC | 6.81e-06 | 4.23e-01 | 0.0875 |
9212 | AIM1 | P2T-E | Human | Esophagus | ESCC | 9.49e-19 | 2.70e-01 | 0.1177 |
9212 | AIM1 | P4T-E | Human | Esophagus | ESCC | 4.75e-06 | 1.92e-01 | 0.1323 |
9212 | AIM1 | P5T-E | Human | Esophagus | ESCC | 1.31e-18 | 6.51e-02 | 0.1327 |
9212 | AIM1 | P8T-E | Human | Esophagus | ESCC | 3.82e-17 | 2.48e-01 | 0.0889 |
9212 | AIM1 | P9T-E | Human | Esophagus | ESCC | 9.50e-09 | 8.24e-03 | 0.1131 |
9212 | AIM1 | P10T-E | Human | Esophagus | ESCC | 9.85e-06 | -6.22e-02 | 0.116 |
9212 | AIM1 | P12T-E | Human | Esophagus | ESCC | 5.63e-11 | 1.53e-01 | 0.1122 |
9212 | AIM1 | P15T-E | Human | Esophagus | ESCC | 1.22e-08 | 2.04e-01 | 0.1149 |
9212 | AIM1 | P16T-E | Human | Esophagus | ESCC | 2.78e-18 | 3.74e-01 | 0.1153 |
9212 | AIM1 | P17T-E | Human | Esophagus | ESCC | 2.21e-05 | 3.09e-01 | 0.1278 |
9212 | AIM1 | P20T-E | Human | Esophagus | ESCC | 8.07e-13 | 2.69e-01 | 0.1124 |
9212 | AIM1 | P21T-E | Human | Esophagus | ESCC | 3.06e-39 | 8.85e-01 | 0.1617 |
9212 | AIM1 | P22T-E | Human | Esophagus | ESCC | 3.17e-04 | -3.24e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIM1 | SNV | Missense_Mutation | c.3485A>T | p.His1162Leu | p.H1162L | Q9Y4K1 | protein_coding | deleterious(0.05) | possibly_damaging(0.808) | TCGA-60-2707-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | PD | |
AIM1 | SNV | Missense_Mutation | novel | c.457N>C | p.Glu153Gln | p.E153Q | Q9Y4K1 | protein_coding | deleterious(0.04) | possibly_damaging(0.723) | TCGA-63-A5MJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vinorelbine | SD |
AIM1 | SNV | Missense_Mutation | novel | c.3875N>G | p.Glu1292Gly | p.E1292G | Q9Y4K1 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-66-2780-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AIM1 | SNV | Missense_Mutation | novel | c.1550N>C | p.Leu517Pro | p.L517P | Q9Y4K1 | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-85-7696-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AIM1 | SNV | Missense_Mutation | rs754338096 | c.1486N>A | p.Val496Met | p.V496M | Q9Y4K1 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.707) | TCGA-85-8355-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AIM1 | SNV | Missense_Mutation | rs763237031 | c.3133N>A | p.Asp1045Asn | p.D1045N | Q9Y4K1 | protein_coding | deleterious(0.03) | possibly_damaging(0.874) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AIM1 | SNV | Missense_Mutation | c.3976N>A | p.Glu1326Lys | p.E1326K | Q9Y4K1 | protein_coding | deleterious(0) | possibly_damaging(0.536) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AIM1 | SNV | Missense_Mutation | novel | c.2821N>G | p.Leu941Val | p.L941V | Q9Y4K1 | protein_coding | tolerated(0.15) | benign(0.411) | TCGA-CN-5356-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
AIM1 | SNV | Missense_Mutation | novel | c.3029N>C | p.Arg1010Thr | p.R1010T | Q9Y4K1 | protein_coding | tolerated(0.09) | benign(0.085) | TCGA-CN-5374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
AIM1 | SNV | Missense_Mutation | novel | c.4091G>T | p.Trp1364Leu | p.W1364L | Q9Y4K1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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