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Gene: AGL |
Gene summary for AGL |
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Gene information | Species | Human | Gene symbol | AGL | Gene ID | 178 |
Gene name | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | |
Gene Alias | GDE | |
Cytomap | 1p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | A0A0S2A4E4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
178 | AGL | CCI_2 | Human | Cervix | CC | 3.47e-21 | 1.53e+00 | 0.5249 |
178 | AGL | CCI_3 | Human | Cervix | CC | 3.04e-14 | 1.01e+00 | 0.516 |
178 | AGL | LZE4T | Human | Esophagus | ESCC | 4.15e-08 | 3.27e-01 | 0.0811 |
178 | AGL | LZE7T | Human | Esophagus | ESCC | 2.02e-02 | 3.58e-01 | 0.0667 |
178 | AGL | LZE8T | Human | Esophagus | ESCC | 2.41e-05 | 1.13e-01 | 0.067 |
178 | AGL | LZE20T | Human | Esophagus | ESCC | 3.43e-03 | 7.66e-02 | 0.0662 |
178 | AGL | LZE24T | Human | Esophagus | ESCC | 2.47e-03 | 7.60e-02 | 0.0596 |
178 | AGL | P1T-E | Human | Esophagus | ESCC | 2.06e-10 | 3.44e-01 | 0.0875 |
178 | AGL | P2T-E | Human | Esophagus | ESCC | 2.43e-27 | 5.20e-01 | 0.1177 |
178 | AGL | P4T-E | Human | Esophagus | ESCC | 2.43e-13 | 3.05e-01 | 0.1323 |
178 | AGL | P5T-E | Human | Esophagus | ESCC | 2.09e-19 | 1.91e-01 | 0.1327 |
178 | AGL | P8T-E | Human | Esophagus | ESCC | 2.00e-28 | 2.79e-01 | 0.0889 |
178 | AGL | P9T-E | Human | Esophagus | ESCC | 1.82e-14 | 2.68e-01 | 0.1131 |
178 | AGL | P10T-E | Human | Esophagus | ESCC | 1.10e-26 | 5.13e-01 | 0.116 |
178 | AGL | P11T-E | Human | Esophagus | ESCC | 4.50e-08 | 1.92e-01 | 0.1426 |
178 | AGL | P12T-E | Human | Esophagus | ESCC | 9.71e-32 | 6.89e-01 | 0.1122 |
178 | AGL | P15T-E | Human | Esophagus | ESCC | 5.05e-13 | 2.48e-01 | 0.1149 |
178 | AGL | P16T-E | Human | Esophagus | ESCC | 2.47e-13 | 1.40e-01 | 0.1153 |
178 | AGL | P17T-E | Human | Esophagus | ESCC | 4.03e-06 | 2.27e-01 | 0.1278 |
178 | AGL | P20T-E | Human | Esophagus | ESCC | 7.39e-11 | 3.13e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075172 | Breast | IDC | muscle organ development | 38/1434 | 327/18723 | 6.63e-03 | 4.62e-02 | 38 |
GO:00075171 | Breast | DCIS | muscle organ development | 37/1390 | 327/18723 | 6.86e-03 | 4.75e-02 | 37 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00159809 | Cervix | CC | energy derivation by oxidation of organic compounds | 74/2311 | 318/18723 | 3.83e-08 | 2.53e-06 | 74 |
GO:004854510 | Cervix | CC | response to steroid hormone | 74/2311 | 339/18723 | 5.71e-07 | 2.09e-05 | 74 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00319609 | Cervix | CC | response to corticosteroid | 39/2311 | 167/18723 | 5.48e-05 | 8.06e-04 | 39 |
GO:00513849 | Cervix | CC | response to glucocorticoid | 35/2311 | 148/18723 | 9.87e-05 | 1.27e-03 | 35 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00075846 | Cervix | CC | response to nutrient | 33/2311 | 174/18723 | 7.65e-03 | 4.07e-02 | 33 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00161973 | Colorectum | FAP | endosomal transport | 56/2622 | 230/18723 | 1.79e-05 | 4.53e-04 | 56 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:000751712 | Endometrium | EEC | muscle organ development | 59/2168 | 327/18723 | 3.49e-04 | 3.85e-03 | 59 |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGL | SNV | Missense_Mutation | novel | c.4513N>G | p.Asn1505Asp | p.N1505D | P35573 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8362-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
AGL | SNV | Missense_Mutation | c.577A>G | p.Thr193Ala | p.T193A | P35573 | protein_coding | deleterious(0.01) | benign(0.118) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
AGL | SNV | Missense_Mutation | c.2765N>A | p.Cys922Tyr | p.C922Y | P35573 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
AGL | SNV | Missense_Mutation | c.1678N>C | p.Ser560Arg | p.S560R | P35573 | protein_coding | deleterious(0.03) | benign(0.213) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
AGL | SNV | Missense_Mutation | c.2234N>A | p.Ala745Asp | p.A745D | P35573 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AGL | SNV | Missense_Mutation | c.4580N>G | p.Glu1527Gly | p.E1527G | P35573 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AGL | SNV | Missense_Mutation | novel | c.511N>C | p.Ser171Pro | p.S171P | P35573 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
AGL | SNV | Missense_Mutation | rs557516658 | c.1064N>T | p.Thr355Met | p.T355M | P35573 | protein_coding | tolerated(0.05) | benign(0.081) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
AGL | insertion | Frame_Shift_Ins | novel | c.617dupA | p.Glu207GlyfsTer9 | p.E207Gfs*9 | P35573 | protein_coding | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
AGL | insertion | Frame_Shift_Ins | rs772172553 | c.3903_3904insA | p.Asn1304LysfsTer7 | p.N1304Kfs*7 | P35573 | protein_coding | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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