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Gene: AFF1 |
Gene summary for AFF1 |
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Gene information | Species | Human | Gene symbol | AFF1 | Gene ID | 4299 |
Gene name | AF4/FMR2 family member 1 | |
Gene Alias | AF4 | |
Cytomap | 4q21.3-q22.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P51825 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4299 | AFF1 | CCI_1 | Human | Cervix | CC | 2.87e-15 | 1.32e+00 | 0.528 |
4299 | AFF1 | CCI_2 | Human | Cervix | CC | 6.67e-14 | 1.38e+00 | 0.5249 |
4299 | AFF1 | CCI_3 | Human | Cervix | CC | 1.26e-22 | 1.29e+00 | 0.516 |
4299 | AFF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.14e-10 | -3.61e-01 | 0.0155 |
4299 | AFF1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.61e-04 | -7.08e-01 | 0.0216 |
4299 | AFF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.09e-16 | 7.58e-01 | -0.1954 |
4299 | AFF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.19e-04 | 7.66e-01 | -0.2602 |
4299 | AFF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.47e-02 | -3.63e-01 | 0.096 |
4299 | AFF1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.80e-02 | -3.56e-01 | 0.0451 |
4299 | AFF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.59e-08 | -6.27e-01 | 0.2585 |
4299 | AFF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.52e-32 | -7.54e-01 | 0.3005 |
4299 | AFF1 | F007 | Human | Colorectum | FAP | 5.72e-06 | -4.52e-01 | 0.1176 |
4299 | AFF1 | A001-C-207 | Human | Colorectum | FAP | 2.80e-04 | -2.64e-01 | 0.1278 |
4299 | AFF1 | A015-C-203 | Human | Colorectum | FAP | 7.16e-40 | -5.78e-01 | -0.1294 |
4299 | AFF1 | A015-C-204 | Human | Colorectum | FAP | 1.98e-09 | -4.46e-01 | -0.0228 |
4299 | AFF1 | A014-C-040 | Human | Colorectum | FAP | 1.92e-06 | -4.29e-01 | -0.1184 |
4299 | AFF1 | A002-C-201 | Human | Colorectum | FAP | 4.83e-20 | -5.03e-01 | 0.0324 |
4299 | AFF1 | A002-C-203 | Human | Colorectum | FAP | 1.35e-04 | -1.22e-01 | 0.2786 |
4299 | AFF1 | A001-C-119 | Human | Colorectum | FAP | 1.69e-10 | -4.36e-01 | -0.1557 |
4299 | AFF1 | A001-C-108 | Human | Colorectum | FAP | 9.50e-19 | -3.43e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0520211 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa052022 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052023 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052027 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520212 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AFF1 | SNV | Missense_Mutation | c.1372N>G | p.Pro458Ala | p.P458A | P51825 | protein_coding | tolerated(0.08) | possibly_damaging(0.45) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
AFF1 | SNV | Missense_Mutation | c.2779N>T | p.Gly927Trp | p.G927W | P51825 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
AFF1 | SNV | Missense_Mutation | c.1762G>A | p.Gly588Arg | p.G588R | P51825 | protein_coding | deleterious(0.02) | probably_damaging(0.911) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
AFF1 | SNV | Missense_Mutation | novel | c.3203N>T | p.Ala1068Val | p.A1068V | P51825 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AFF1 | insertion | Frame_Shift_Ins | novel | c.988_989insA | p.Thr332AsnfsTer22 | p.T332Nfs*22 | P51825 | protein_coding | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
AFF1 | deletion | Frame_Shift_Del | novel | c.989delN | p.Thr332GlnfsTer3 | p.T332Qfs*3 | P51825 | protein_coding | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AFF1 | insertion | In_Frame_Ins | novel | c.275_276insAAAAGGAGAATT | p.Asn92delinsLysLysGlyGluPhe | p.N92delinsKKGEF | P51825 | protein_coding | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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