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Gene: ADNP |
Gene summary for ADNP |
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Gene information | Species | Human | Gene symbol | ADNP | Gene ID | 23394 |
Gene name | activity dependent neuroprotector homeobox | |
Gene Alias | ADNP1 | |
Cytomap | 20q13.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H2P0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23394 | ADNP | CA_HPV_3 | Human | Cervix | CC | 4.59e-02 | 1.04e-01 | 0.0414 |
23394 | ADNP | CCI_1 | Human | Cervix | CC | 3.01e-04 | 6.21e-01 | 0.528 |
23394 | ADNP | CCI_2 | Human | Cervix | CC | 9.58e-11 | 8.44e-01 | 0.5249 |
23394 | ADNP | CCI_3 | Human | Cervix | CC | 1.70e-16 | 9.09e-01 | 0.516 |
23394 | ADNP | T3 | Human | Cervix | CC | 2.96e-04 | 1.44e-01 | 0.1389 |
23394 | ADNP | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.66e-08 | -5.06e-01 | 0.0155 |
23394 | ADNP | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.01e-02 | -5.70e-01 | -0.2061 |
23394 | ADNP | F007 | Human | Colorectum | FAP | 8.30e-03 | 8.30e-02 | 0.1176 |
23394 | ADNP | A001-C-207 | Human | Colorectum | FAP | 2.66e-03 | -9.62e-02 | 0.1278 |
23394 | ADNP | A015-C-203 | Human | Colorectum | FAP | 5.30e-29 | -3.39e-01 | -0.1294 |
23394 | ADNP | A015-C-204 | Human | Colorectum | FAP | 3.73e-05 | -2.21e-01 | -0.0228 |
23394 | ADNP | A014-C-040 | Human | Colorectum | FAP | 1.37e-04 | -1.58e-01 | -0.1184 |
23394 | ADNP | A002-C-201 | Human | Colorectum | FAP | 3.08e-16 | -3.08e-01 | 0.0324 |
23394 | ADNP | A001-C-119 | Human | Colorectum | FAP | 7.37e-08 | -2.86e-01 | -0.1557 |
23394 | ADNP | A001-C-108 | Human | Colorectum | FAP | 6.00e-11 | -1.44e-01 | -0.0272 |
23394 | ADNP | A002-C-205 | Human | Colorectum | FAP | 1.02e-24 | -3.15e-01 | -0.1236 |
23394 | ADNP | A001-C-104 | Human | Colorectum | FAP | 2.73e-02 | -7.39e-02 | 0.0184 |
23394 | ADNP | A015-C-005 | Human | Colorectum | FAP | 1.03e-03 | -1.57e-01 | -0.0336 |
23394 | ADNP | A015-C-006 | Human | Colorectum | FAP | 8.29e-17 | -2.62e-01 | -0.0994 |
23394 | ADNP | A015-C-106 | Human | Colorectum | FAP | 3.51e-10 | -2.48e-01 | -0.0511 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00316689 | Cervix | CC | cellular response to extracellular stimulus | 59/2311 | 246/18723 | 3.03e-07 | 1.24e-05 | 59 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00107206 | Cervix | CC | positive regulation of cell development | 64/2311 | 298/18723 | 5.69e-06 | 1.41e-04 | 64 |
GO:00313467 | Cervix | CC | positive regulation of cell projection organization | 72/2311 | 353/18723 | 1.04e-05 | 2.32e-04 | 72 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:000974310 | Cervix | CC | response to carbohydrate | 53/2311 | 253/18723 | 7.02e-05 | 9.85e-04 | 53 |
GO:007099710 | Cervix | CC | neuron death | 70/2311 | 361/18723 | 7.50e-05 | 1.03e-03 | 70 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00433939 | Cervix | CC | regulation of protein binding | 42/2311 | 196/18723 | 2.27e-04 | 2.55e-03 | 42 |
GO:190121410 | Cervix | CC | regulation of neuron death | 61/2311 | 319/18723 | 3.11e-04 | 3.31e-03 | 61 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ADNP | CD8TEX | Oral cavity | NEOLP | CDC42,HNRNPH1,C1orf56, etc. | 1.10e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADNP | deletion | Frame_Shift_Del | novel | c.1896delN | p.Gly633AspfsTer43 | p.G633Dfs*43 | Q9H2P0 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ADNP | deletion | Frame_Shift_Del | c.64delN | p.Ile22TyrfsTer14 | p.I22Yfs*14 | Q9H2P0 | protein_coding | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |||
ADNP | insertion | Frame_Shift_Ins | novel | c.1851dupA | p.Asp618ArgfsTer20 | p.D618Rfs*20 | Q9H2P0 | protein_coding | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | ||
ADNP | insertion | Frame_Shift_Ins | novel | c.308_309insA | p.Asn103LysfsTer2 | p.N103Kfs*2 | Q9H2P0 | protein_coding | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ADNP | insertion | Frame_Shift_Ins | rs761350619 | c.3047_3048insA | p.Ala1017GlyfsTer6 | p.A1017Gfs*6 | Q9H2P0 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
ADNP | insertion | Frame_Shift_Ins | novel | c.2062_2063insT | p.Arg688MetfsTer12 | p.R688Mfs*12 | Q9H2P0 | protein_coding | TCGA-F1-A448-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | ||
ADNP | insertion | Frame_Shift_Ins | rs761350619 | c.3047_3048insA | p.Ala1017GlyfsTer6 | p.A1017Gfs*6 | Q9H2P0 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
ADNP | insertion | Frame_Shift_Ins | novel | c.64_65insA | p.Ile22AsnfsTer3 | p.I22Nfs*3 | Q9H2P0 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
ADNP | deletion | Frame_Shift_Del | c.64delN | p.Ile22TyrfsTer14 | p.I22Yfs*14 | Q9H2P0 | protein_coding | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |||
ADNP | SNV | Missense_Mutation | novel | c.2810N>G | p.Glu937Gly | p.E937G | Q9H2P0 | protein_coding | tolerated_low_confidence(0.23) | benign(0) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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