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Gene: ADGRG6 |
Gene summary for ADGRG6 |
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Gene information | Species | Human | Gene symbol | ADGRG6 | Gene ID | 57211 |
Gene name | adhesion G protein-coupled receptor G6 | |
Gene Alias | APG1 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003007 | UniProtAcc | Q86SQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57211 | ADGRG6 | NAFLD1 | Human | Liver | NAFLD | 9.15e-11 | 1.02e+00 | -0.04 |
57211 | ADGRG6 | S43 | Human | Liver | Cirrhotic | 4.66e-09 | -8.30e-02 | -0.0187 |
57211 | ADGRG6 | HCC1_Meng | Human | Liver | HCC | 1.02e-89 | -5.60e-02 | 0.0246 |
57211 | ADGRG6 | HCC2_Meng | Human | Liver | HCC | 3.22e-50 | 1.98e-01 | 0.0107 |
57211 | ADGRG6 | cirrhotic1 | Human | Liver | Cirrhotic | 5.43e-07 | -2.94e-01 | 0.0202 |
57211 | ADGRG6 | cirrhotic2 | Human | Liver | Cirrhotic | 2.74e-06 | -2.36e-01 | 0.0201 |
57211 | ADGRG6 | cirrhotic3 | Human | Liver | Cirrhotic | 4.38e-03 | -3.18e-01 | 0.0215 |
57211 | ADGRG6 | HCC2 | Human | Liver | HCC | 3.05e-06 | 3.26e+00 | 0.5341 |
57211 | ADGRG6 | HCC5 | Human | Liver | HCC | 5.01e-03 | 7.43e-01 | 0.4932 |
57211 | ADGRG6 | Pt13.a | Human | Liver | HCC | 6.25e-16 | -4.44e-01 | 0.021 |
57211 | ADGRG6 | Pt13.b | Human | Liver | HCC | 6.54e-08 | -4.44e-01 | 0.0251 |
57211 | ADGRG6 | Pt13.c | Human | Liver | HCC | 1.36e-04 | -4.44e-01 | 0.0076 |
57211 | ADGRG6 | Pt14.d | Human | Liver | HCC | 1.22e-16 | -4.44e-01 | 0.0143 |
57211 | ADGRG6 | S027 | Human | Liver | HCC | 2.34e-09 | 1.14e+00 | 0.2446 |
57211 | ADGRG6 | S028 | Human | Liver | HCC | 1.21e-24 | 1.21e+00 | 0.2503 |
57211 | ADGRG6 | S029 | Human | Liver | HCC | 3.07e-17 | 1.18e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042063 | Liver | Cirrhotic | gliogenesis | 98/4634 | 301/18723 | 1.28e-03 | 8.60e-03 | 98 |
GO:0010001 | Liver | Cirrhotic | glial cell differentiation | 75/4634 | 225/18723 | 2.24e-03 | 1.36e-02 | 75 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00420631 | Liver | HCC | gliogenesis | 148/7958 | 301/18723 | 1.10e-02 | 4.07e-02 | 148 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRG6 | SNV | Missense_Mutation | c.1793G>T | p.Gly598Val | p.G598V | Q86SQ4 | protein_coding | tolerated(0.05) | probably_damaging(0.997) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ADGRG6 | SNV | Missense_Mutation | c.2179N>T | p.Pro727Ser | p.P727S | Q86SQ4 | protein_coding | tolerated(0.35) | benign(0.046) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADGRG6 | SNV | Missense_Mutation | novel | c.767N>C | p.Val256Ala | p.V256A | Q86SQ4 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-94-8035-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | |
ADGRG6 | SNV | Missense_Mutation | novel | c.1975N>A | p.Glu659Lys | p.E659K | Q86SQ4 | protein_coding | tolerated(0.1) | possibly_damaging(0.828) | TCGA-98-A53J-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADGRG6 | SNV | Missense_Mutation | novel | c.3694N>A | p.Asp1232Asn | p.D1232N | Q86SQ4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-98-A53J-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADGRG6 | SNV | Missense_Mutation | novel | c.441N>G | p.Ile147Met | p.I147M | Q86SQ4 | protein_coding | tolerated(0.1) | possibly_damaging(0.452) | TCGA-BB-4227-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | docetaxel | PD |
ADGRG6 | SNV | Missense_Mutation | rs777617124 | c.1466A>G | p.Asn489Ser | p.N489S | Q86SQ4 | protein_coding | tolerated(0.15) | benign(0.093) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ADGRG6 | SNV | Missense_Mutation | novel | c.3661N>C | p.Asp1221His | p.D1221H | Q86SQ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7252-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ADGRG6 | SNV | Missense_Mutation | rs756919427 | c.1244N>T | p.Ser415Phe | p.S415F | Q86SQ4 | protein_coding | deleterious(0.04) | benign(0.081) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ADGRG6 | SNV | Missense_Mutation | novel | c.1492N>G | p.Gln498Glu | p.Q498E | Q86SQ4 | protein_coding | tolerated(0.83) | benign(0.001) | TCGA-D6-6823-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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