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Gene: PIK3CA |
Gene summary for PIK3CA |
Gene summary. |
Gene information | Species | Human | Gene symbol | PIK3CA | Gene ID | 5290 |
Gene name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | |
Gene Alias | CLAPO | |
Cytomap | 3q26.32 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | P42336 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5290 | PIK3CA | CA_HPV_2 | Human | Cervix | CC | 6.44e-06 | 3.23e-01 | 0.0391 |
5290 | PIK3CA | CCI_2 | Human | Cervix | CC | 3.01e-09 | 1.19e+00 | 0.5249 |
5290 | PIK3CA | CCI_3 | Human | Cervix | CC | 8.00e-05 | 6.32e-01 | 0.516 |
5290 | PIK3CA | HCC1_Meng | Human | Liver | HCC | 7.90e-28 | 1.41e-02 | 0.0246 |
5290 | PIK3CA | HCC2_Meng | Human | Liver | HCC | 8.04e-25 | 1.29e-01 | 0.0107 |
5290 | PIK3CA | HCC1 | Human | Liver | HCC | 6.95e-10 | 3.40e+00 | 0.5336 |
5290 | PIK3CA | HCC2 | Human | Liver | HCC | 1.23e-13 | 3.78e+00 | 0.5341 |
5290 | PIK3CA | S028 | Human | Liver | HCC | 9.79e-07 | 3.87e-01 | 0.2503 |
5290 | PIK3CA | S029 | Human | Liver | HCC | 2.66e-04 | 3.62e-01 | 0.2581 |
5290 | PIK3CA | male-WTA | Human | Thyroid | PTC | 3.74e-13 | 5.74e-02 | 0.1037 |
5290 | PIK3CA | PTC01 | Human | Thyroid | PTC | 2.99e-12 | 4.20e-02 | 0.1899 |
5290 | PIK3CA | PTC04 | Human | Thyroid | PTC | 2.28e-16 | 2.51e-01 | 0.1927 |
5290 | PIK3CA | PTC05 | Human | Thyroid | PTC | 3.40e-11 | 4.25e-01 | 0.2065 |
5290 | PIK3CA | PTC06 | Human | Thyroid | PTC | 9.79e-15 | 4.11e-01 | 0.2057 |
5290 | PIK3CA | PTC07 | Human | Thyroid | PTC | 8.04e-18 | 2.27e-01 | 0.2044 |
5290 | PIK3CA | ATC09 | Human | Thyroid | ATC | 4.79e-05 | 1.50e-01 | 0.2871 |
5290 | PIK3CA | ATC11 | Human | Thyroid | ATC | 1.53e-05 | 4.32e-01 | 0.3386 |
5290 | PIK3CA | ATC12 | Human | Thyroid | ATC | 1.44e-08 | 8.02e-02 | 0.34 |
5290 | PIK3CA | ATC13 | Human | Thyroid | ATC | 1.25e-43 | 7.28e-01 | 0.34 |
5290 | PIK3CA | ATC1 | Human | Thyroid | ATC | 4.24e-06 | 2.20e-01 | 0.2878 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:00453339 | Cervix | CC | cellular respiration | 66/2311 | 230/18723 | 2.07e-11 | 5.39e-09 | 66 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
GO:00159809 | Cervix | CC | energy derivation by oxidation of organic compounds | 74/2311 | 318/18723 | 3.83e-08 | 2.53e-06 | 74 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0520820 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0541520 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0493218 | Cervix | CC | Non-alcoholic fatty liver disease | 58/1267 | 155/8465 | 3.58e-12 | 1.05e-10 | 6.23e-11 | 58 |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0541720 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa0516720 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0421810 | Cervix | CC | Cellular senescence | 49/1267 | 156/8465 | 1.30e-07 | 1.63e-06 | 9.61e-07 | 49 |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0491520 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa0516920 | Cervix | CC | Epstein-Barr virus infection | 57/1267 | 202/8465 | 7.30e-07 | 7.39e-06 | 4.37e-06 | 57 |
hsa0516620 | Cervix | CC | Human T-cell leukemia virus 1 infection | 61/1267 | 222/8465 | 8.13e-07 | 7.98e-06 | 4.72e-06 | 61 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIK3CA | SNV | Missense_Mutation | novel | c.1421N>C | p.Glu474Ala | p.E474A | P42336 | protein_coding | deleterious(0.03) | possibly_damaging(0.655) | TCGA-J9-A8CL-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PIK3CA | SNV | Missense_Mutation | rs121913279 | c.3140A>G | p.His1047Arg | p.H1047R | P42336 | protein_coding | tolerated(0.11) | benign(0.085) | TCGA-QU-A6IN-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
PIK3CA | SNV | Missense_Mutation | rs121913273 | c.1624G>A | p.Glu542Lys | p.E542K | P42336 | protein_coding | deleterious(0.04) | probably_damaging(0.912) | TCGA-VP-A87H-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
PIK3CA | SNV | Missense_Mutation | novel | c.1705N>A | p.Leu569Ile | p.L569I | P42336 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PIK3CA | SNV | Missense_Mutation | rs121913273 | c.1624G>A | p.Glu542Lys | p.E542K | P42336 | protein_coding | deleterious(0.04) | probably_damaging(0.912) | TCGA-XK-AAJ3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
PIK3CA | SNV | Missense_Mutation | rs772110575 | c.113G>A | p.Arg38His | p.R38H | P42336 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIK3CA | SNV | Missense_Mutation | rs121913273 | c.1624G>A | p.Glu542Lys | p.E542K | P42336 | protein_coding | deleterious(0.04) | probably_damaging(0.912) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PIK3CA | SNV | Missense_Mutation | rs397517201 | c.1637A>G | p.Gln546Arg | p.Q546R | P42336 | protein_coding | deleterious(0.02) | probably_damaging(0.934) | TCGA-B7-A5TK-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | CR |
PIK3CA | SNV | Missense_Mutation | rs121913284 | c.1035N>A | p.Asn345Lys | p.N345K | P42336 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BR-4253-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PIK3CA | SNV | Missense_Mutation | rs121913279 | c.3140A>G | p.His1047Arg | p.H1047R | P42336 | protein_coding | tolerated(0.11) | benign(0.085) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | inhibitor | 249565638 | ALPELISIB | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | inhibitor | INK-1117 | INK-1117 | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | inhibitor | 354702297 | GSK-1059615 | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | MS417 | 26058079 | ||
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | Olaparib | OLAPARIB | 26909613 | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | NSC-79888 | CHEMBL1939433 | 22212721 | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | CH-5132799 | PA-799 | ||
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | inhibitor | 381118806 | ACALISIB | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | ALPELISIB | ALPELISIB | 31091374,24608574 | |
5290 | PIK3CA | PHOSPHATIDYLINOSITOL 3 KINASE, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, KINASE, ENZYME, SERINE THREONINE KINASE, DRUG RESISTANCE | Linsitinib | LINSITINIB | 27196766 |
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