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Gene: ZNF644 |
Gene summary for ZNF644 |
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Gene information | Species | Human | Gene symbol | ZNF644 | Gene ID | 84146 |
Gene name | zinc finger protein 644 | |
Gene Alias | BM-005 | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H582 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84146 | ZNF644 | CA_HPV_1 | Human | Cervix | CC | 1.42e-02 | -1.57e-02 | 0.0264 |
84146 | ZNF644 | CCI_1 | Human | Cervix | CC | 3.07e-05 | 8.75e-01 | 0.528 |
84146 | ZNF644 | CCI_2 | Human | Cervix | CC | 3.23e-13 | 1.23e+00 | 0.5249 |
84146 | ZNF644 | CCI_3 | Human | Cervix | CC | 2.13e-09 | 1.03e+00 | 0.516 |
84146 | ZNF644 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.11e-31 | -9.07e-01 | 0.0155 |
84146 | ZNF644 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.85e-17 | -8.23e-01 | -0.1808 |
84146 | ZNF644 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.88e-03 | -8.31e-01 | 0.0216 |
84146 | ZNF644 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.10e-03 | -5.41e-01 | -0.0811 |
84146 | ZNF644 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.72e-07 | -6.06e-01 | -0.1088 |
84146 | ZNF644 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.44e-16 | -8.72e-01 | -0.1207 |
84146 | ZNF644 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.96e-09 | -6.40e-01 | -0.1526 |
84146 | ZNF644 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-30 | -7.24e-01 | -0.1464 |
84146 | ZNF644 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.02e-27 | -6.87e-01 | -0.1001 |
84146 | ZNF644 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.04e-09 | -5.38e-01 | -0.059 |
84146 | ZNF644 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.20e-05 | -8.06e-01 | -0.1706 |
84146 | ZNF644 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.30e-06 | -8.17e-01 | -0.2061 |
84146 | ZNF644 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.53e-04 | -8.88e-01 | -0.1462 |
84146 | ZNF644 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.72e-02 | -6.09e-01 | -0.0842 |
84146 | ZNF644 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.55e-20 | -7.79e-01 | 0.096 |
84146 | ZNF644 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.23e-03 | -6.99e-01 | 0.0446 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF644 | SNV | Missense_Mutation | novel | c.907N>C | p.Tyr303His | p.Y303H | Q9H582 | protein_coding | tolerated(0.43) | probably_damaging(0.986) | TCGA-2Y-A9HB-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF644 | SNV | Missense_Mutation | novel | c.3964A>T | p.Met1322Leu | p.M1322L | Q9H582 | protein_coding | deleterious(0.04) | benign(0.27) | TCGA-DD-AADP-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF644 | SNV | Missense_Mutation | c.800N>T | p.Gln267Leu | p.Q267L | Q9H582 | protein_coding | deleterious(0.01) | benign(0.15) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
ZNF644 | SNV | Missense_Mutation | novel | c.1201N>T | p.Thr401Ser | p.T401S | Q9H582 | protein_coding | tolerated(0.41) | benign(0.079) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
ZNF644 | SNV | Missense_Mutation | rs769317289 | c.3298N>T | p.Arg1100Cys | p.R1100C | Q9H582 | protein_coding | deleterious(0.04) | benign(0.365) | TCGA-44-A4SU-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF644 | SNV | Missense_Mutation | c.61N>T | p.Gly21Trp | p.G21W | Q9H582 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.793) | TCGA-55-1592-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF644 | SNV | Missense_Mutation | c.2012N>T | p.Ser671Leu | p.S671L | Q9H582 | protein_coding | tolerated(0.19) | benign(0.073) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
ZNF644 | SNV | Missense_Mutation | c.3538N>T | p.Met1180Leu | p.M1180L | Q9H582 | protein_coding | tolerated(1) | benign(0) | TCGA-91-6828-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF644 | SNV | Missense_Mutation | novel | c.3976G>T | p.Ala1326Ser | p.A1326S | Q9H582 | protein_coding | deleterious(0.01) | benign(0.088) | TCGA-95-7944-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF644 | SNV | Missense_Mutation | c.1646N>T | p.Gly549Val | p.G549V | Q9H582 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-NJ-A4YI-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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