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Gene: ZNF608 |
Gene summary for ZNF608 |
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Gene information | Species | Human | Gene symbol | ZNF608 | Gene ID | 57507 |
Gene name | zinc finger protein 608 | |
Gene Alias | NY-REN-36 | |
Cytomap | 5q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B3KPE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57507 | ZNF608 | P2T-E | Human | Esophagus | ESCC | 2.37e-07 | 7.21e-02 | 0.1177 |
57507 | ZNF608 | P4T-E | Human | Esophagus | ESCC | 1.73e-03 | 8.14e-02 | 0.1323 |
57507 | ZNF608 | P8T-E | Human | Esophagus | ESCC | 2.21e-09 | 2.31e-01 | 0.0889 |
57507 | ZNF608 | P10T-E | Human | Esophagus | ESCC | 2.46e-05 | 5.25e-02 | 0.116 |
57507 | ZNF608 | P11T-E | Human | Esophagus | ESCC | 9.11e-03 | 1.11e-01 | 0.1426 |
57507 | ZNF608 | P12T-E | Human | Esophagus | ESCC | 4.44e-16 | 3.28e-01 | 0.1122 |
57507 | ZNF608 | P15T-E | Human | Esophagus | ESCC | 8.96e-09 | 1.60e-01 | 0.1149 |
57507 | ZNF608 | P16T-E | Human | Esophagus | ESCC | 3.82e-04 | 3.01e-02 | 0.1153 |
57507 | ZNF608 | P21T-E | Human | Esophagus | ESCC | 7.49e-08 | 1.26e-01 | 0.1617 |
57507 | ZNF608 | P24T-E | Human | Esophagus | ESCC | 1.78e-04 | 4.43e-02 | 0.1287 |
57507 | ZNF608 | P26T-E | Human | Esophagus | ESCC | 1.81e-14 | 2.08e-01 | 0.1276 |
57507 | ZNF608 | P27T-E | Human | Esophagus | ESCC | 1.45e-15 | 1.60e-01 | 0.1055 |
57507 | ZNF608 | P28T-E | Human | Esophagus | ESCC | 1.13e-05 | 9.20e-02 | 0.1149 |
57507 | ZNF608 | P32T-E | Human | Esophagus | ESCC | 1.39e-13 | 1.22e-01 | 0.1666 |
57507 | ZNF608 | P36T-E | Human | Esophagus | ESCC | 1.41e-03 | 2.07e-01 | 0.1187 |
57507 | ZNF608 | P40T-E | Human | Esophagus | ESCC | 1.26e-05 | 1.22e-01 | 0.109 |
57507 | ZNF608 | P48T-E | Human | Esophagus | ESCC | 1.53e-02 | 4.47e-02 | 0.0959 |
57507 | ZNF608 | P52T-E | Human | Esophagus | ESCC | 6.33e-11 | 5.29e-02 | 0.1555 |
57507 | ZNF608 | P54T-E | Human | Esophagus | ESCC | 2.60e-05 | 7.49e-02 | 0.0975 |
57507 | ZNF608 | P57T-E | Human | Esophagus | ESCC | 2.53e-10 | 1.51e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF608 | SNV | Missense_Mutation | c.3781N>C | p.Asp1261His | p.D1261H | Q9ULD9 | protein_coding | deleterious(0.01) | possibly_damaging(0.717) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF608 | SNV | Missense_Mutation | novel | c.3239N>G | p.Tyr1080Cys | p.Y1080C | Q9ULD9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-21-5784-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | novel | c.3169N>T | p.Ala1057Ser | p.A1057S | Q9ULD9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
ZNF608 | SNV | Missense_Mutation | rs761615973 | c.3473C>T | p.Ser1158Phe | p.S1158F | Q9ULD9 | protein_coding | deleterious(0) | benign(0.405) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | c.2644N>C | p.Glu882Gln | p.E882Q | Q9ULD9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-77-8136-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF608 | SNV | Missense_Mutation | rs527721257 | c.1880N>T | p.Ser627Phe | p.S627F | Q9ULD9 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF608 | deletion | In_Frame_Del | novel | c.1047_1061delTGTGGGTGTCAATAC | p.Val350_Thr354del | p.V350_T354del | Q9ULD9 | protein_coding | TCGA-22-4591-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemzar | PD | ||
ZNF608 | SNV | Missense_Mutation | novel | c.4480N>G | p.Gln1494Glu | p.Q1494E | Q9ULD9 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-BB-4227-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | docetaxel | PD |
ZNF608 | SNV | Missense_Mutation | novel | c.247N>G | p.Leu83Val | p.L83V | Q9ULD9 | protein_coding | deleterious(0.02) | benign(0.391) | TCGA-CN-6988-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF608 | SNV | Missense_Mutation | novel | c.3150N>T | p.Lys1050Asn | p.K1050N | Q9ULD9 | protein_coding | deleterious(0.01) | possibly_damaging(0.865) | TCGA-CQ-A4CA-01 | Oral cavity | head & neck squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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