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Gene: ZNF471 |
Gene summary for ZNF471 |
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Gene information | Species | Human | Gene symbol | ZNF471 | Gene ID | 57573 |
Gene name | zinc finger protein 471 | |
Gene Alias | ERP1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BX82 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57573 | ZNF471 | HCC1 | Human | Liver | HCC | 9.91e-07 | 2.30e+00 | 0.5336 |
57573 | ZNF471 | HCC2 | Human | Liver | HCC | 1.60e-20 | 3.32e+00 | 0.5341 |
57573 | ZNF471 | HCC5 | Human | Liver | HCC | 1.24e-02 | 2.05e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF471 | SNV | Missense_Mutation | novel | c.1496N>T | p.Ser499Ile | p.S499I | Q9BX82 | protein_coding | deleterious(0.05) | benign(0.238) | TCGA-YL-A8SK-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | CR | |
ZNF471 | SNV | Missense_Mutation | c.1196N>A | p.Gly399Glu | p.G399E | Q9BX82 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF471 | SNV | Missense_Mutation | rs773139042 | c.155N>T | p.Ser52Leu | p.S52L | Q9BX82 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-BR-A4PD-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF471 | SNV | Missense_Mutation | c.832A>T | p.Ile278Phe | p.I278F | Q9BX82 | protein_coding | deleterious(0) | possibly_damaging(0.711) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ZNF471 | SNV | Missense_Mutation | rs142290015 | c.1088N>A | p.Arg363His | p.R363H | Q9BX82 | protein_coding | deleterious(0.04) | possibly_damaging(0.883) | TCGA-KB-A93J-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ZNF471 | SNV | Missense_Mutation | novel | c.347T>G | p.Leu116Arg | p.L116R | Q9BX82 | protein_coding | deleterious(0.04) | benign(0.178) | TCGA-RD-A7BT-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF471 | SNV | Missense_Mutation | rs766567776 | c.1048N>A | p.Glu350Lys | p.E350K | Q9BX82 | protein_coding | tolerated(0.06) | possibly_damaging(0.595) | TCGA-RD-A7BW-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
ZNF471 | SNV | Missense_Mutation | c.845N>C | p.Arg282Thr | p.R282T | Q9BX82 | protein_coding | deleterious(0.03) | probably_damaging(0.927) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |
ZNF471 | SNV | Missense_Mutation | novel | c.347N>A | p.Leu116His | p.L116H | Q9BX82 | protein_coding | deleterious(0.04) | possibly_damaging(0.46) | TCGA-VQ-A91V-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
ZNF471 | SNV | Missense_Mutation | novel | c.1222N>C | p.Cys408Arg | p.C408R | Q9BX82 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VQ-A922-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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