![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF470 |
Gene summary for ZNF470 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF470 | Gene ID | 388566 |
Gene name | zinc finger protein 470 | |
Gene Alias | CZF-1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ECI4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388566 | ZNF470 | HCC1 | Human | Liver | HCC | 8.27e-05 | 1.38e+00 | 0.5336 |
388566 | ZNF470 | HCC2 | Human | Liver | HCC | 3.94e-24 | 3.89e+00 | 0.5341 |
388566 | ZNF470 | HCC5 | Human | Liver | HCC | 7.23e-03 | 1.85e-01 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF470 | SNV | Missense_Mutation | c.618N>C | p.Lys206Asn | p.K206N | Q6ECI4 | protein_coding | tolerated(0.21) | benign(0) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF470 | SNV | Missense_Mutation | novel | c.2048N>A | p.Gly683Glu | p.G683E | Q6ECI4 | protein_coding | tolerated(0.14) | possibly_damaging(0.825) | TCGA-CV-7091-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF470 | SNV | Missense_Mutation | novel | c.1970C>T | p.Ala657Val | p.A657V | Q6ECI4 | protein_coding | deleterious(0.02) | benign(0.138) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF470 | SNV | Missense_Mutation | rs763736722 | c.1003N>C | p.Thr335Pro | p.T335P | Q6ECI4 | protein_coding | deleterious(0) | benign(0.212) | TCGA-F7-A50I-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF470 | SNV | Missense_Mutation | novel | c.1416N>C | p.Gln472His | p.Q472H | Q6ECI4 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
ZNF470 | insertion | In_Frame_Ins | novel | c.2124_2125insTGTATGAAT | p.Ser708_Ser709insCysMetAsn | p.S708_S709insCMN | Q6ECI4 | protein_coding | TCGA-CV-A45U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ZNF470 | insertion | Frame_Shift_Ins | novel | c.2126_2127insTCTGA | p.Ala710LeufsTer45 | p.A710Lfs*45 | Q6ECI4 | protein_coding | TCGA-CV-A45U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ZNF470 | SNV | Missense_Mutation | c.1693N>G | p.Tyr565Asp | p.Y565D | Q6ECI4 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-QU-A6IM-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
ZNF470 | SNV | Missense_Mutation | novel | c.356C>A | p.Ala119Glu | p.A119E | Q6ECI4 | protein_coding | tolerated(0.79) | benign(0) | TCGA-3M-AB47-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
ZNF470 | SNV | Missense_Mutation | c.884A>G | p.Gln295Arg | p.Q295R | Q6ECI4 | protein_coding | tolerated(0.22) | possibly_damaging(0.768) | TCGA-BR-6801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |