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Gene: YTHDC2 |
Gene summary for YTHDC2 |
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Gene information | Species | Human | Gene symbol | YTHDC2 | Gene ID | 64848 |
Gene name | YTH domain containing 2 | |
Gene Alias | CAHL | |
Cytomap | 5q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H6S0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64848 | YTHDC2 | CCI_2 | Human | Cervix | CC | 2.95e-05 | 7.55e-01 | 0.5249 |
64848 | YTHDC2 | CCI_3 | Human | Cervix | CC | 1.82e-05 | 6.62e-01 | 0.516 |
64848 | YTHDC2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.91e-12 | -5.05e-01 | 0.0155 |
64848 | YTHDC2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.65e-05 | -3.37e-01 | -0.1464 |
64848 | YTHDC2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.28e-06 | -3.89e-01 | -0.1001 |
64848 | YTHDC2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.83e-04 | -4.16e-01 | -0.059 |
64848 | YTHDC2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.36e-05 | -4.23e-01 | 0.096 |
64848 | YTHDC2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.36e-03 | -4.41e-01 | 0.0338 |
64848 | YTHDC2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.40e-04 | -3.21e-01 | 0.0674 |
64848 | YTHDC2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.59e-02 | -4.59e-01 | 0.0588 |
64848 | YTHDC2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.07e-05 | -3.16e-01 | 0.3859 |
64848 | YTHDC2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.77e-14 | -4.57e-01 | 0.3005 |
64848 | YTHDC2 | A015-C-203 | Human | Colorectum | FAP | 3.36e-16 | -3.04e-01 | -0.1294 |
64848 | YTHDC2 | A015-C-204 | Human | Colorectum | FAP | 6.89e-03 | -2.62e-01 | -0.0228 |
64848 | YTHDC2 | A014-C-040 | Human | Colorectum | FAP | 5.01e-04 | -5.10e-01 | -0.1184 |
64848 | YTHDC2 | A002-C-201 | Human | Colorectum | FAP | 5.37e-08 | -3.16e-01 | 0.0324 |
64848 | YTHDC2 | A002-C-203 | Human | Colorectum | FAP | 7.43e-03 | -1.83e-01 | 0.2786 |
64848 | YTHDC2 | A001-C-119 | Human | Colorectum | FAP | 1.15e-05 | -4.25e-01 | -0.1557 |
64848 | YTHDC2 | A001-C-108 | Human | Colorectum | FAP | 2.78e-09 | -1.43e-01 | -0.0272 |
64848 | YTHDC2 | A002-C-205 | Human | Colorectum | FAP | 5.00e-12 | -2.55e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:001907910 | Cervix | CC | viral genome replication | 35/2311 | 131/18723 | 6.11e-06 | 1.49e-04 | 35 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:00346129 | Cervix | CC | response to tumor necrosis factor | 55/2311 | 253/18723 | 1.75e-05 | 3.32e-04 | 55 |
GO:00457862 | Cervix | CC | negative regulation of cell cycle | 67/2311 | 385/18723 | 2.21e-03 | 1.59e-02 | 67 |
GO:00459302 | Cervix | CC | negative regulation of mitotic cell cycle | 44/2311 | 235/18723 | 3.02e-03 | 1.99e-02 | 44 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0035821 | Colorectum | AD | modulation of process of other organism | 34/3918 | 106/18723 | 4.73e-03 | 3.22e-02 | 34 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00190582 | Colorectum | MSS | viral life cycle | 111/3467 | 317/18723 | 1.65e-12 | 2.95e-10 | 111 |
GO:00444032 | Colorectum | MSS | biological process involved in symbiotic interaction | 93/3467 | 290/18723 | 1.72e-08 | 9.85e-07 | 93 |
GO:00190792 | Colorectum | MSS | viral genome replication | 49/3467 | 131/18723 | 2.73e-07 | 1.11e-05 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YTHDC2 | deletion | Frame_Shift_Del | c.82delN | p.Gly29AlafsTer8 | p.G29Afs*8 | Q9H6S0 | protein_coding | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
YTHDC2 | deletion | Frame_Shift_Del | novel | c.2527delN | p.Met844TrpfsTer8 | p.M844Wfs*8 | Q9H6S0 | protein_coding | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
YTHDC2 | SNV | Missense_Mutation | rs559215760 | c.2384T>C | p.Met795Thr | p.M795T | Q9H6S0 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-CC-A3M9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
YTHDC2 | SNV | Missense_Mutation | c.73N>C | p.Cys25Arg | p.C25R | Q9H6S0 | protein_coding | tolerated_low_confidence(0.15) | benign(0) | TCGA-CC-A7IK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
YTHDC2 | SNV | Missense_Mutation | c.1846A>T | p.Ile616Phe | p.I616F | Q9H6S0 | protein_coding | deleterious(0) | benign(0.074) | TCGA-ED-A459-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Ancillary | alvesin | CR | |
YTHDC2 | SNV | Missense_Mutation | novel | c.2202A>G | p.Ile734Met | p.I734M | Q9H6S0 | protein_coding | tolerated(0.11) | benign(0.058) | TCGA-LG-A9QC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
YTHDC2 | SNV | Missense_Mutation | c.462N>A | p.Phe154Leu | p.F154L | Q9H6S0 | protein_coding | tolerated(0.85) | benign(0) | TCGA-55-6971-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YTHDC2 | SNV | Missense_Mutation | c.3220C>G | p.Leu1074Val | p.L1074V | Q9H6S0 | protein_coding | tolerated(0.25) | benign(0.019) | TCGA-55-8204-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YTHDC2 | SNV | Missense_Mutation | c.1885N>G | p.Leu629Val | p.L629V | Q9H6S0 | protein_coding | deleterious(0.03) | benign(0.336) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YTHDC2 | SNV | Missense_Mutation | novel | c.38C>T | p.Ala13Val | p.A13V | Q9H6S0 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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