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Gene: XPO4 |
Gene summary for XPO4 |
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Gene information | Species | Human | Gene symbol | XPO4 | Gene ID | 64328 |
Gene name | exportin 4 | |
Gene Alias | exp4 | |
Cytomap | 13q12.11 | |
Gene Type | protein-coding | GO ID | GO:0006611 | UniProtAcc | Q9C0E2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64328 | XPO4 | CCI_1 | Human | Cervix | CC | 4.42e-04 | 4.64e-01 | 0.528 |
64328 | XPO4 | CCI_2 | Human | Cervix | CC | 3.84e-11 | 9.35e-01 | 0.5249 |
64328 | XPO4 | CCI_3 | Human | Cervix | CC | 6.83e-15 | 7.50e-01 | 0.516 |
64328 | XPO4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.28e-03 | -4.58e-01 | -0.1808 |
64328 | XPO4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.59e-02 | -3.59e-01 | -0.1207 |
64328 | XPO4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.83e-09 | 7.66e-01 | 0.281 |
64328 | XPO4 | A001-C-207 | Human | Colorectum | FAP | 3.58e-08 | -3.96e-01 | 0.1278 |
64328 | XPO4 | A015-C-203 | Human | Colorectum | FAP | 4.92e-27 | -5.17e-01 | -0.1294 |
64328 | XPO4 | A015-C-204 | Human | Colorectum | FAP | 1.02e-07 | -3.86e-01 | -0.0228 |
64328 | XPO4 | A014-C-040 | Human | Colorectum | FAP | 1.96e-03 | -3.02e-01 | -0.1184 |
64328 | XPO4 | A002-C-201 | Human | Colorectum | FAP | 1.09e-18 | -5.09e-01 | 0.0324 |
64328 | XPO4 | A002-C-203 | Human | Colorectum | FAP | 1.85e-04 | -2.82e-01 | 0.2786 |
64328 | XPO4 | A001-C-119 | Human | Colorectum | FAP | 2.49e-13 | -5.99e-01 | -0.1557 |
64328 | XPO4 | A001-C-108 | Human | Colorectum | FAP | 7.88e-17 | -4.08e-01 | -0.0272 |
64328 | XPO4 | A002-C-205 | Human | Colorectum | FAP | 1.09e-23 | -5.04e-01 | -0.1236 |
64328 | XPO4 | A001-C-104 | Human | Colorectum | FAP | 1.11e-06 | -4.21e-01 | 0.0184 |
64328 | XPO4 | A015-C-005 | Human | Colorectum | FAP | 1.07e-04 | -2.99e-01 | -0.0336 |
64328 | XPO4 | A015-C-006 | Human | Colorectum | FAP | 3.74e-15 | -2.75e-01 | -0.0994 |
64328 | XPO4 | A015-C-106 | Human | Colorectum | FAP | 1.17e-10 | -3.67e-01 | -0.0511 |
64328 | XPO4 | A002-C-114 | Human | Colorectum | FAP | 7.32e-23 | -5.97e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:00468229 | Cervix | CC | regulation of nucleocytoplasmic transport | 31/2311 | 106/18723 | 2.68e-06 | 7.87e-05 | 31 |
GO:00903167 | Cervix | CC | positive regulation of intracellular protein transport | 41/2311 | 160/18723 | 3.24e-06 | 8.80e-05 | 41 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00331579 | Cervix | CC | regulation of intracellular protein transport | 52/2311 | 229/18723 | 8.16e-06 | 1.88e-04 | 52 |
GO:00511689 | Cervix | CC | nuclear export | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00323889 | Cervix | CC | positive regulation of intracellular transport | 46/2311 | 202/18723 | 2.45e-05 | 4.24e-04 | 46 |
GO:00468248 | Cervix | CC | positive regulation of nucleocytoplasmic transport | 19/2311 | 62/18723 | 1.11e-04 | 1.40e-03 | 19 |
GO:00468259 | Cervix | CC | regulation of protein export from nucleus | 12/2311 | 30/18723 | 1.23e-04 | 1.53e-03 | 12 |
GO:00066116 | Cervix | CC | protein export from nucleus | 17/2311 | 57/18723 | 3.61e-04 | 3.75e-03 | 17 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XPO4 | SNV | Missense_Mutation | novel | c.3393N>T | p.Met1131Ile | p.M1131I | Q9C0E2 | protein_coding | tolerated(0.63) | benign(0) | TCGA-BR-7715-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
XPO4 | SNV | Missense_Mutation | c.331G>A | p.Val111Ile | p.V111I | Q9C0E2 | protein_coding | deleterious(0.02) | possibly_damaging(0.621) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
XPO4 | SNV | Missense_Mutation | c.1431N>C | p.Gln477His | p.Q477H | Q9C0E2 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
XPO4 | SNV | Missense_Mutation | rs767647297 | c.674N>A | p.Arg225His | p.R225H | Q9C0E2 | protein_coding | tolerated(0.24) | benign(0.043) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
XPO4 | SNV | Missense_Mutation | c.394A>G | p.Ile132Val | p.I132V | Q9C0E2 | protein_coding | tolerated(0.28) | benign(0.06) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
XPO4 | SNV | Missense_Mutation | c.815G>T | p.Ser272Ile | p.S272I | Q9C0E2 | protein_coding | tolerated(0.18) | benign(0.11) | TCGA-EQ-8122-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
XPO4 | SNV | Missense_Mutation | c.1316N>A | p.Cys439Tyr | p.C439Y | Q9C0E2 | protein_coding | deleterious(0) | benign(0.385) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
XPO4 | deletion | Frame_Shift_Del | c.2492delT | p.Leu831Ter | p.L831* | Q9C0E2 | protein_coding | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |||
XPO4 | SNV | Missense_Mutation | c.1961A>G | p.Glu654Gly | p.E654G | Q9C0E2 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-ET-A3DR-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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