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Gene: VPS13B |
Gene summary for VPS13B |
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Gene information | Species | Human | Gene symbol | VPS13B | Gene ID | 157680 |
Gene name | vacuolar protein sorting 13 homolog B | |
Gene Alias | CHS1 | |
Cytomap | 8q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q7Z7G8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
157680 | VPS13B | CCI_1 | Human | Cervix | CC | 4.83e-17 | 1.07e+00 | 0.528 |
157680 | VPS13B | CCI_2 | Human | Cervix | CC | 1.55e-16 | 1.71e+00 | 0.5249 |
157680 | VPS13B | CCI_3 | Human | Cervix | CC | 4.46e-22 | 1.21e+00 | 0.516 |
157680 | VPS13B | CCII_1 | Human | Cervix | CC | 2.08e-06 | 2.63e-01 | 0.3249 |
157680 | VPS13B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.11e-29 | -7.81e-01 | 0.0155 |
157680 | VPS13B | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.02e-05 | -4.67e-01 | -0.1808 |
157680 | VPS13B | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.18e-06 | -7.96e-01 | 0.0216 |
157680 | VPS13B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.25e-06 | -6.06e-01 | -0.1207 |
157680 | VPS13B | HTA11_83_2000001011 | Human | Colorectum | SER | 1.26e-03 | -4.72e-01 | -0.1526 |
157680 | VPS13B | HTA11_696_2000001011 | Human | Colorectum | AD | 4.00e-15 | -4.62e-01 | -0.1464 |
157680 | VPS13B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.18e-06 | -3.76e-01 | -0.1001 |
157680 | VPS13B | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.27e-06 | -7.65e-01 | -0.2061 |
157680 | VPS13B | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.87e-02 | -6.30e-01 | -0.00410000000000005 |
157680 | VPS13B | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.64e-05 | -6.34e-01 | -0.0179 |
157680 | VPS13B | HTA11_866_3004761011 | Human | Colorectum | AD | 3.88e-17 | -6.00e-01 | 0.096 |
157680 | VPS13B | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.69e-07 | -6.99e-01 | 0.0446 |
157680 | VPS13B | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.82e-04 | -7.94e-01 | 0.0451 |
157680 | VPS13B | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.17e-04 | -6.84e-01 | 0.0528 |
157680 | VPS13B | HTA11_6801_2000001011 | Human | Colorectum | SER | 9.80e-03 | -7.65e-01 | 0.0171 |
157680 | VPS13B | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.22e-04 | -4.59e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VPS13B | SNV | Missense_Mutation | rs772958839 | c.1916G>A | p.Arg639Gln | p.R639Q | Q7Z7G8 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
VPS13B | SNV | Missense_Mutation | rs746562006 | c.4597N>T | p.Pro1533Ser | p.P1533S | Q7Z7G8 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VPS13B | SNV | Missense_Mutation | c.8591N>T | p.Arg2864Met | p.R2864M | Q7Z7G8 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VPS13B | SNV | Missense_Mutation | c.11231N>G | p.Pro3744Arg | p.P3744R | Q7Z7G8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3727-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
VPS13B | SNV | Missense_Mutation | novel | c.9N>T | p.Glu3Asp | p.E3D | Q7Z7G8 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
VPS13B | SNV | Missense_Mutation | novel | c.610N>C | p.Asn204His | p.N204H | Q7Z7G8 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
VPS13B | SNV | Missense_Mutation | novel | c.2631N>C | p.Lys877Asn | p.K877N | Q7Z7G8 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
VPS13B | SNV | Missense_Mutation | c.6506N>G | p.Val2169Gly | p.V2169G | Q7Z7G8 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
VPS13B | SNV | Missense_Mutation | rs763678767 | c.6944N>A | p.Ser2315Tyr | p.S2315Y | Q7Z7G8 | protein_coding | tolerated(0.09) | benign(0.172) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
VPS13B | SNV | Missense_Mutation | c.4223N>G | p.Leu1408Arg | p.L1408R | Q7Z7G8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A026-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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