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Gene: UNC13B |
Gene summary for UNC13B |
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Gene information | Species | Human | Gene symbol | UNC13B | Gene ID | 10497 |
Gene name | unc-13 homolog B | |
Gene Alias | MUNC13 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O14795 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10497 | UNC13B | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.83e-05 | -3.14e-01 | 0.0155 |
10497 | UNC13B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.03e-07 | -3.71e-01 | 0.294 |
10497 | UNC13B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.16e-09 | -7.30e-01 | 0.2585 |
10497 | UNC13B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.22e-26 | -7.24e-01 | 0.3005 |
10497 | UNC13B | A015-C-203 | Human | Colorectum | FAP | 4.12e-27 | -5.02e-01 | -0.1294 |
10497 | UNC13B | A015-C-204 | Human | Colorectum | FAP | 6.25e-06 | -2.65e-01 | -0.0228 |
10497 | UNC13B | A014-C-040 | Human | Colorectum | FAP | 8.84e-04 | -2.28e-01 | -0.1184 |
10497 | UNC13B | A002-C-201 | Human | Colorectum | FAP | 8.75e-14 | -2.92e-01 | 0.0324 |
10497 | UNC13B | A001-C-119 | Human | Colorectum | FAP | 1.06e-08 | -4.90e-01 | -0.1557 |
10497 | UNC13B | A001-C-108 | Human | Colorectum | FAP | 8.99e-12 | -1.36e-01 | -0.0272 |
10497 | UNC13B | A002-C-205 | Human | Colorectum | FAP | 6.59e-26 | -5.56e-01 | -0.1236 |
10497 | UNC13B | A015-C-005 | Human | Colorectum | FAP | 1.57e-03 | -2.05e-01 | -0.0336 |
10497 | UNC13B | A015-C-006 | Human | Colorectum | FAP | 2.93e-19 | -5.00e-01 | -0.0994 |
10497 | UNC13B | A015-C-106 | Human | Colorectum | FAP | 1.66e-06 | -2.47e-01 | -0.0511 |
10497 | UNC13B | A002-C-114 | Human | Colorectum | FAP | 1.10e-20 | -4.82e-01 | -0.1561 |
10497 | UNC13B | A015-C-104 | Human | Colorectum | FAP | 1.66e-30 | -4.18e-01 | -0.1899 |
10497 | UNC13B | A001-C-014 | Human | Colorectum | FAP | 1.21e-09 | -2.52e-01 | 0.0135 |
10497 | UNC13B | A002-C-016 | Human | Colorectum | FAP | 3.22e-22 | -4.07e-01 | 0.0521 |
10497 | UNC13B | A015-C-002 | Human | Colorectum | FAP | 3.99e-13 | -3.56e-01 | -0.0763 |
10497 | UNC13B | A001-C-007 | Human | Colorectum | CRC | 2.53e-05 | -5.85e-01 | 0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0034284 | Colorectum | AD | response to monosaccharide | 76/3918 | 225/18723 | 4.64e-06 | 1.23e-04 | 76 |
GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
GO:0009746 | Colorectum | AD | response to hexose | 73/3918 | 219/18723 | 1.20e-05 | 2.65e-04 | 73 |
GO:0009749 | Colorectum | AD | response to glucose | 71/3918 | 212/18723 | 1.31e-05 | 2.85e-04 | 71 |
GO:0042593 | Colorectum | AD | glucose homeostasis | 83/3918 | 258/18723 | 1.44e-05 | 3.11e-04 | 83 |
GO:0001678 | Colorectum | AD | cellular glucose homeostasis | 60/3918 | 172/18723 | 1.49e-05 | 3.18e-04 | 60 |
GO:0071322 | Colorectum | AD | cellular response to carbohydrate stimulus | 56/3918 | 163/18723 | 4.61e-05 | 7.97e-04 | 56 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0071333 | Colorectum | AD | cellular response to glucose stimulus | 52/3918 | 151/18723 | 7.88e-05 | 1.25e-03 | 52 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0071331 | Colorectum | AD | cellular response to hexose stimulus | 52/3918 | 153/18723 | 1.16e-04 | 1.71e-03 | 52 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071326 | Colorectum | AD | cellular response to monosaccharide stimulus | 52/3918 | 154/18723 | 1.40e-04 | 1.98e-03 | 52 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNC13B | SNV | Missense_Mutation | novel | c.700G>A | p.Asp234Asn | p.D234N | O14795 | protein_coding | deleterious_low_confidence(0.01) | benign(0.231) | TCGA-2Y-A9H0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
UNC13B | deletion | In_Frame_Del | novel | c.4679_4729delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Cys1561_Gly1577del | p.C1561_G1577del | O14795 | protein_coding | TCGA-G3-A25Y-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
UNC13B | SNV | Missense_Mutation | novel | c.4763G>T | p.Ser1588Ile | p.S1588I | O14795 | protein_coding | deleterious(0.04) | benign(0.312) | TCGA-38-4626-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
UNC13B | SNV | Missense_Mutation | novel | c.4303N>T | p.Val1435Leu | p.V1435L | O14795 | protein_coding | tolerated_low_confidence(0.06) | benign(0.36) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC13B | SNV | Missense_Mutation | novel | c.901A>T | p.Ser301Cys | p.S301C | O14795 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.846) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UNC13B | SNV | Missense_Mutation | c.1475N>G | p.Tyr492Cys | p.Y492C | O14795 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UNC13B | SNV | Missense_Mutation | novel | c.3007N>G | p.Ser1003Gly | p.S1003G | O14795 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC13B | SNV | Missense_Mutation | novel | c.1981N>A | p.Arg661Ser | p.R661S | O14795 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-6981-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | chemo | CR |
UNC13B | SNV | Missense_Mutation | c.1816N>C | p.Val606Leu | p.V606L | O14795 | protein_coding | deleterious(0) | benign(0.412) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
UNC13B | SNV | Missense_Mutation | c.1483N>A | p.Glu495Lys | p.E495K | O14795 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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