![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: UBE4B |
Gene summary for UBE4B |
![]() |
Gene information | Species | Human | Gene symbol | UBE4B | Gene ID | 10277 |
Gene name | ubiquitination factor E4B | |
Gene Alias | E4 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | O95155 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10277 | UBE4B | CCI_1 | Human | Cervix | CC | 1.34e-09 | 1.00e+00 | 0.528 |
10277 | UBE4B | CCI_2 | Human | Cervix | CC | 1.38e-12 | 1.37e+00 | 0.5249 |
10277 | UBE4B | CCI_3 | Human | Cervix | CC | 8.37e-13 | 9.72e-01 | 0.516 |
10277 | UBE4B | AEH-subject1 | Human | Endometrium | AEH | 5.38e-04 | 2.38e-01 | -0.3059 |
10277 | UBE4B | AEH-subject2 | Human | Endometrium | AEH | 3.08e-02 | 1.54e-01 | -0.2525 |
10277 | UBE4B | AEH-subject3 | Human | Endometrium | AEH | 1.79e-02 | 1.95e-01 | -0.2576 |
10277 | UBE4B | AEH-subject4 | Human | Endometrium | AEH | 1.41e-05 | 2.87e-01 | -0.2657 |
10277 | UBE4B | AEH-subject5 | Human | Endometrium | AEH | 2.70e-07 | 3.34e-01 | -0.2953 |
10277 | UBE4B | EEC-subject1 | Human | Endometrium | EEC | 1.27e-02 | 2.50e-01 | -0.2682 |
10277 | UBE4B | EEC-subject4 | Human | Endometrium | EEC | 3.48e-02 | 2.35e-01 | -0.2571 |
10277 | UBE4B | GSM5276934 | Human | Endometrium | EEC | 3.65e-04 | -9.18e-02 | -0.0913 |
10277 | UBE4B | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.17e-02 | -7.52e-02 | -0.1869 |
10277 | UBE4B | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 9.94e-03 | 3.39e-02 | -0.1875 |
10277 | UBE4B | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.40e-04 | -2.53e-02 | -0.1883 |
10277 | UBE4B | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.79e-04 | -9.11e-03 | -0.1934 |
10277 | UBE4B | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.66e-10 | -9.92e-02 | -0.1917 |
10277 | UBE4B | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.63e-04 | -6.57e-02 | -0.1916 |
10277 | UBE4B | LZE2T | Human | Esophagus | ESCC | 9.32e-03 | 3.85e-01 | 0.082 |
10277 | UBE4B | LZE4T | Human | Esophagus | ESCC | 1.49e-12 | 4.88e-01 | 0.0811 |
10277 | UBE4B | LZE7T | Human | Esophagus | ESCC | 2.34e-07 | 5.92e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:003497610 | Cervix | CC | response to endoplasmic reticulum stress | 57/2311 | 256/18723 | 5.81e-06 | 1.42e-04 | 57 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00094112 | Cervix | CC | response to UV | 33/2311 | 149/18723 | 5.51e-04 | 5.29e-03 | 33 |
GO:00094163 | Cervix | CC | response to light stimulus | 54/2311 | 320/18723 | 1.03e-02 | 4.97e-02 | 54 |
GO:001049816 | Endometrium | AEH | proteasomal protein catabolic process | 108/2100 | 490/18723 | 2.73e-12 | 4.67e-10 | 108 |
GO:004316116 | Endometrium | AEH | proteasome-mediated ubiquitin-dependent protein catabolic process | 88/2100 | 412/18723 | 1.54e-09 | 1.36e-07 | 88 |
GO:003497616 | Endometrium | AEH | response to endoplasmic reticulum stress | 62/2100 | 256/18723 | 2.88e-09 | 2.13e-07 | 62 |
GO:00002098 | Endometrium | AEH | protein polyubiquitination | 44/2100 | 236/18723 | 4.83e-04 | 4.97e-03 | 44 |
GO:00365033 | Endometrium | AEH | ERAD pathway | 23/2100 | 107/18723 | 1.55e-03 | 1.27e-02 | 23 |
GO:000931410 | Endometrium | AEH | response to radiation | 70/2100 | 456/18723 | 3.99e-03 | 2.68e-02 | 70 |
GO:00304332 | Endometrium | AEH | ubiquitin-dependent ERAD pathway | 18/2100 | 85/18723 | 5.63e-03 | 3.46e-02 | 18 |
GO:001049817 | Endometrium | EEC | proteasomal protein catabolic process | 112/2168 | 490/18723 | 6.99e-13 | 1.40e-10 | 112 |
GO:004316117 | Endometrium | EEC | proteasome-mediated ubiquitin-dependent protein catabolic process | 92/2168 | 412/18723 | 3.01e-10 | 3.23e-08 | 92 |
GO:003497617 | Endometrium | EEC | response to endoplasmic reticulum stress | 63/2168 | 256/18723 | 3.84e-09 | 2.71e-07 | 63 |
GO:000020913 | Endometrium | EEC | protein polyubiquitination | 46/2168 | 236/18723 | 2.65e-04 | 3.04e-03 | 46 |
GO:003650312 | Endometrium | EEC | ERAD pathway | 24/2168 | 107/18723 | 1.03e-03 | 9.07e-03 | 24 |
GO:003043311 | Endometrium | EEC | ubiquitin-dependent ERAD pathway | 19/2168 | 85/18723 | 3.43e-03 | 2.32e-02 | 19 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0412016 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0412017 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0412023 | Endometrium | EEC | Ubiquitin mediated proteolysis | 41/1237 | 142/8465 | 7.86e-06 | 9.58e-05 | 7.14e-05 | 41 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0412033 | Endometrium | EEC | Ubiquitin mediated proteolysis | 41/1237 | 142/8465 | 7.86e-06 | 9.58e-05 | 7.14e-05 | 41 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
Page: 1 2 3 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE4B | SNV | Missense_Mutation | c.784N>A | p.Ser262Thr | p.S262T | O95155 | protein_coding | tolerated_low_confidence(0.18) | benign(0.186) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBE4B | SNV | Missense_Mutation | c.3347N>A | p.Arg1116Gln | p.R1116Q | O95155 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBE4B | SNV | Missense_Mutation | c.3617N>G | p.Leu1206Arg | p.L1206R | O95155 | protein_coding | tolerated(0.51) | benign(0.044) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBE4B | SNV | Missense_Mutation | c.3711N>A | p.Met1237Ile | p.M1237I | O95155 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
UBE4B | SNV | Missense_Mutation | rs765404233 | c.2320N>T | p.Arg774Cys | p.R774C | O95155 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
UBE4B | SNV | Missense_Mutation | rs772803836 | c.1069N>A | p.Ala357Thr | p.A357T | O95155 | protein_coding | tolerated_low_confidence(0.24) | benign(0) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBE4B | SNV | Missense_Mutation | rs761955109 | c.31N>T | p.Arg11Trp | p.R11W | O95155 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
UBE4B | SNV | Missense_Mutation | c.3442C>G | p.Pro1148Ala | p.P1148A | O95155 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
UBE4B | SNV | Missense_Mutation | rs749630439 | c.284N>T | p.Thr95Met | p.T95M | O95155 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-IN-AB1X-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
UBE4B | SNV | Missense_Mutation | novel | c.1990G>A | p.Val664Ile | p.V664I | O95155 | protein_coding | tolerated(0.24) | benign(0.084) | TCGA-KB-A6F7-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |