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Gene: TMPRSS15 |
Gene summary for TMPRSS15 |
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Gene information | Species | Human | Gene symbol | TMPRSS15 | Gene ID | 5651 |
Gene name | transmembrane serine protease 15 | |
Gene Alias | ENTK | |
Cytomap | 21q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P98073 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5651 | TMPRSS15 | Pat01-B | Human | Stomach | GC | 6.27e-43 | 8.77e-01 | 0.5754 |
5651 | TMPRSS15 | Pat03-B | Human | Stomach | GC | 1.62e-38 | 1.10e+00 | 0.3693 |
5651 | TMPRSS15 | Pat17-B | Human | Stomach | GC | 8.97e-18 | 5.64e-01 | 0.3109 |
5651 | TMPRSS15 | SIM_1 | Human | Stomach | SIM | 3.98e-11 | 4.84e-01 | 0.3573 |
5651 | TMPRSS15 | SIM_2 | Human | Stomach | SIM | 8.72e-11 | 3.39e-01 | 0.3139 |
5651 | TMPRSS15 | SIM_4 | Human | Stomach | SIM | 7.38e-15 | 5.89e-01 | 0.2664 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMPRSS15 | SNV | Missense_Mutation | c.1990N>T | p.Gly664Cys | p.G664C | P98073 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
TMPRSS15 | SNV | Missense_Mutation | c.389N>T | p.Trp130Leu | p.W130L | P98073 | protein_coding | tolerated(0.58) | benign(0.031) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
TMPRSS15 | SNV | Missense_Mutation | novel | c.1375G>A | p.Gly459Arg | p.G459R | P98073 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TMPRSS15 | SNV | Missense_Mutation | c.418N>A | p.Leu140Met | p.L140M | P98073 | protein_coding | tolerated(0.05) | possibly_damaging(0.823) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMPRSS15 | SNV | Missense_Mutation | novel | c.415N>C | p.Glu139Gln | p.E139Q | P98073 | protein_coding | tolerated(0.32) | benign(0.164) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TMPRSS15 | SNV | Missense_Mutation | rs763542195 | c.2402G>A | p.Gly801Asp | p.G801D | P98073 | protein_coding | deleterious(0.03) | benign(0.213) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD |
TMPRSS15 | SNV | Missense_Mutation | c.645C>A | p.Asp215Glu | p.D215E | P98073 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-8655-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMPRSS15 | SNV | Missense_Mutation | c.938C>G | p.Ala313Gly | p.A313G | P98073 | protein_coding | deleterious(0) | possibly_damaging(0.582) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMPRSS15 | SNV | Missense_Mutation | novel | c.1505N>A | p.Cys502Tyr | p.C502Y | P98073 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TMPRSS15 | SNV | Missense_Mutation | c.2398N>T | p.Val800Leu | p.V800L | P98073 | protein_coding | deleterious(0) | possibly_damaging(0.807) | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | THONZONIUM BROMIDE | THONZONIUM BROMIDE | ||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | US9024044, 62 | |||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | CALMIDAZOLIUM CHLORIDE | CALMIDAZOLIUM CHLORIDE | ||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | NSC-60340 | CHEMBL1534034 | ||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | US9024044, 3 | |||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | US9346821, B-13 | |||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | US8609715, A-1 | |||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | US8609715, A-26 | |||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | GNF-PF-254 | CHEMBL461579 | ||
5651 | TMPRSS15 | PROTEASE, DRUGGABLE GENOME, ENZYME | US8609715, B-61 |
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