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Gene: TMC5 |
Gene summary for TMC5 |
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Gene information | Species | Human | Gene symbol | TMC5 | Gene ID | 79838 |
Gene name | transmembrane channel like 5 | |
Gene Alias | TMC5 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6UXY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79838 | TMC5 | GSM4909281 | Human | Breast | IDC | 5.53e-10 | -2.50e-01 | 0.21 |
79838 | TMC5 | GSM4909282 | Human | Breast | IDC | 1.34e-09 | -2.50e-01 | -0.0288 |
79838 | TMC5 | GSM4909285 | Human | Breast | IDC | 6.74e-13 | -2.52e-01 | 0.21 |
79838 | TMC5 | GSM4909286 | Human | Breast | IDC | 3.30e-12 | -2.55e-01 | 0.1081 |
79838 | TMC5 | GSM4909287 | Human | Breast | IDC | 1.16e-08 | -2.52e-01 | 0.2057 |
79838 | TMC5 | GSM4909293 | Human | Breast | IDC | 1.82e-07 | 3.65e-01 | 0.1581 |
79838 | TMC5 | GSM4909295 | Human | Breast | IDC | 4.72e-02 | -2.46e-01 | 0.0898 |
79838 | TMC5 | GSM4909296 | Human | Breast | IDC | 4.23e-05 | -2.09e-01 | 0.1524 |
79838 | TMC5 | GSM4909297 | Human | Breast | IDC | 6.72e-04 | 1.38e-01 | 0.1517 |
79838 | TMC5 | GSM4909302 | Human | Breast | IDC | 5.28e-17 | 6.17e-01 | 0.1545 |
79838 | TMC5 | GSM4909311 | Human | Breast | IDC | 3.10e-09 | -1.69e-01 | 0.1534 |
79838 | TMC5 | GSM4909315 | Human | Breast | IDC | 1.49e-12 | -2.55e-01 | 0.21 |
79838 | TMC5 | GSM4909319 | Human | Breast | IDC | 1.41e-12 | -2.13e-01 | 0.1563 |
79838 | TMC5 | GSM4909320 | Human | Breast | IDC | 2.44e-02 | -1.41e-01 | 0.1575 |
79838 | TMC5 | GSM4909321 | Human | Breast | IDC | 1.99e-05 | -1.96e-01 | 0.1559 |
79838 | TMC5 | brca2 | Human | Breast | Precancer | 1.65e-06 | 4.77e-01 | -0.024 |
79838 | TMC5 | brca3 | Human | Breast | Precancer | 3.38e-12 | 4.55e-01 | -0.0263 |
79838 | TMC5 | M1 | Human | Breast | IDC | 4.32e-03 | -2.43e-01 | 0.1577 |
79838 | TMC5 | NCCBC5 | Human | Breast | DCIS | 3.53e-03 | -2.06e-01 | 0.2046 |
79838 | TMC5 | P1 | Human | Breast | IDC | 1.36e-06 | -2.40e-01 | 0.1527 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMC5 | deletion | Frame_Shift_Del | novel | c.437_438delAT | p.Tyr146CysfsTer25 | p.Y146Cfs*25 | Q6UXY8 | protein_coding | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | ||
TMC5 | insertion | Frame_Shift_Ins | novel | c.660dupT | p.Gly221TrpfsTer9 | p.G221Wfs*9 | Q6UXY8 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMC5 | insertion | Frame_Shift_Ins | novel | c.1171dupA | p.Ser391LysfsTer109 | p.S391Kfs*109 | Q6UXY8 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | ||
TMC5 | SNV | Missense_Mutation | c.284N>G | p.Ser95Cys | p.S95C | Q6UXY8 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.628) | TCGA-DO-A2HM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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