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Gene: TEX2 |
Gene summary for TEX2 |
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Gene information | Species | Human | Gene symbol | TEX2 | Gene ID | 55852 |
Gene name | testis expressed 2 | |
Gene Alias | HT008 | |
Cytomap | 17q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q8IWB9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55852 | TEX2 | LZE4T | Human | Esophagus | ESCC | 9.21e-03 | 1.39e-01 | 0.0811 |
55852 | TEX2 | LZE24T | Human | Esophagus | ESCC | 8.00e-04 | 1.31e-01 | 0.0596 |
55852 | TEX2 | P1T-E | Human | Esophagus | ESCC | 1.25e-16 | 9.13e-01 | 0.0875 |
55852 | TEX2 | P2T-E | Human | Esophagus | ESCC | 2.75e-08 | 5.85e-02 | 0.1177 |
55852 | TEX2 | P8T-E | Human | Esophagus | ESCC | 1.62e-09 | 6.61e-02 | 0.0889 |
55852 | TEX2 | P10T-E | Human | Esophagus | ESCC | 3.27e-06 | 4.42e-02 | 0.116 |
55852 | TEX2 | P11T-E | Human | Esophagus | ESCC | 1.06e-08 | 4.00e-01 | 0.1426 |
55852 | TEX2 | P12T-E | Human | Esophagus | ESCC | 2.66e-05 | 8.31e-02 | 0.1122 |
55852 | TEX2 | P15T-E | Human | Esophagus | ESCC | 1.53e-08 | 1.93e-01 | 0.1149 |
55852 | TEX2 | P16T-E | Human | Esophagus | ESCC | 1.37e-04 | 2.69e-02 | 0.1153 |
55852 | TEX2 | P21T-E | Human | Esophagus | ESCC | 3.18e-14 | 1.77e-01 | 0.1617 |
55852 | TEX2 | P22T-E | Human | Esophagus | ESCC | 4.57e-08 | 4.02e-02 | 0.1236 |
55852 | TEX2 | P23T-E | Human | Esophagus | ESCC | 3.26e-08 | 2.50e-01 | 0.108 |
55852 | TEX2 | P26T-E | Human | Esophagus | ESCC | 2.55e-06 | 1.58e-01 | 0.1276 |
55852 | TEX2 | P27T-E | Human | Esophagus | ESCC | 2.92e-04 | 3.64e-02 | 0.1055 |
55852 | TEX2 | P28T-E | Human | Esophagus | ESCC | 6.91e-10 | 1.36e-01 | 0.1149 |
55852 | TEX2 | P30T-E | Human | Esophagus | ESCC | 5.27e-07 | 1.75e-01 | 0.137 |
55852 | TEX2 | P31T-E | Human | Esophagus | ESCC | 1.00e-02 | 4.19e-02 | 0.1251 |
55852 | TEX2 | P32T-E | Human | Esophagus | ESCC | 8.93e-17 | 1.94e-01 | 0.1666 |
55852 | TEX2 | P36T-E | Human | Esophagus | ESCC | 9.76e-05 | 1.54e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00068881 | Colorectum | SER | endoplasmic reticulum to Golgi vesicle-mediated transport | 34/2897 | 130/18723 | 1.13e-03 | 1.29e-02 | 34 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00068882 | Colorectum | MSS | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3467 | 130/18723 | 2.17e-05 | 4.60e-04 | 44 |
GO:00068883 | Colorectum | MSI-H | endoplasmic reticulum to Golgi vesicle-mediated transport | 22/1319 | 130/18723 | 1.05e-04 | 3.24e-03 | 22 |
GO:00481933 | Colorectum | MSI-H | Golgi vesicle transport | 39/1319 | 296/18723 | 1.17e-04 | 3.51e-03 | 39 |
GO:001623616 | Esophagus | HGIN | macroautophagy | 77/2587 | 291/18723 | 7.15e-09 | 4.61e-07 | 77 |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:19030089 | Esophagus | HGIN | organelle disassembly | 36/2587 | 114/18723 | 8.60e-07 | 3.58e-05 | 36 |
GO:00619128 | Esophagus | HGIN | selective autophagy | 19/2587 | 68/18723 | 1.68e-03 | 1.85e-02 | 19 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:190300816 | Esophagus | ESCC | organelle disassembly | 89/8552 | 114/18723 | 1.36e-12 | 5.80e-11 | 89 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00066652 | Esophagus | ESCC | sphingolipid metabolic process | 96/8552 | 155/18723 | 3.21e-05 | 2.66e-04 | 96 |
GO:006191215 | Esophagus | ESCC | selective autophagy | 47/8552 | 68/18723 | 7.81e-05 | 5.80e-04 | 47 |
GO:00108765 | Liver | NAFLD | lipid localization | 79/1882 | 448/18723 | 4.75e-07 | 2.92e-05 | 79 |
GO:00068694 | Liver | NAFLD | lipid transport | 71/1882 | 398/18723 | 1.16e-06 | 5.59e-05 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEX2 | SNV | Missense_Mutation | c.673N>T | p.Thr225Ser | p.T225S | Q8IWB9 | protein_coding | tolerated(0.17) | probably_damaging(0.956) | TCGA-CV-6956-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
TEX2 | SNV | Missense_Mutation | novel | c.2659N>T | p.Leu887Phe | p.L887F | Q8IWB9 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEX2 | SNV | Missense_Mutation | novel | c.503C>G | p.Ser168Cys | p.S168C | Q8IWB9 | protein_coding | deleterious(0.04) | probably_damaging(0.964) | TCGA-QK-A6IG-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD |
TEX2 | SNV | Missense_Mutation | c.1265N>G | p.Tyr422Cys | p.Y422C | Q8IWB9 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TEX2 | SNV | Missense_Mutation | novel | c.147N>T | p.Glu49Asp | p.E49D | Q8IWB9 | protein_coding | deleterious_low_confidence(0.04) | benign(0.438) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TEX2 | SNV | Missense_Mutation | rs782361810 | c.419N>T | p.Ser140Leu | p.S140L | Q8IWB9 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEX2 | SNV | Missense_Mutation | c.385A>G | p.Thr129Ala | p.T129A | Q8IWB9 | protein_coding | tolerated_low_confidence(0.72) | benign(0.075) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TEX2 | SNV | Missense_Mutation | novel | c.1896N>T | p.Lys632Asn | p.K632N | Q8IWB9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TEX2 | SNV | Missense_Mutation | c.1702C>T | p.His568Tyr | p.H568Y | Q8IWB9 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
TEX2 | SNV | Missense_Mutation | rs782479358 | c.1289N>T | p.Thr430Met | p.T430M | Q8IWB9 | protein_coding | tolerated(0.17) | benign(0.044) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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