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Gene: TARBP1 |
Gene summary for TARBP1 |
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Gene information | Species | Human | Gene symbol | TARBP1 | Gene ID | 6894 |
Gene name | TAR (HIV-1) RNA binding protein 1 | |
Gene Alias | TRM3 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q13395 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6894 | TARBP1 | CCI_2 | Human | Cervix | CC | 2.16e-02 | 4.93e-01 | 0.5249 |
6894 | TARBP1 | CCI_3 | Human | Cervix | CC | 1.36e-11 | 7.62e-01 | 0.516 |
6894 | TARBP1 | sample3 | Human | Cervix | CC | 2.04e-02 | 8.57e-02 | 0.1387 |
6894 | TARBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.11e-09 | -4.12e-01 | 0.0155 |
6894 | TARBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.06e-07 | -5.48e-01 | -0.1808 |
6894 | TARBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.96e-06 | -4.31e-01 | -0.1464 |
6894 | TARBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.58e-06 | -3.74e-01 | -0.1001 |
6894 | TARBP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.81e-03 | -6.55e-01 | -0.2061 |
6894 | TARBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.39e-02 | -3.99e-01 | 0.096 |
6894 | TARBP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.90e-03 | -2.95e-01 | 0.3005 |
6894 | TARBP1 | F007 | Human | Colorectum | FAP | 1.27e-03 | -4.00e-01 | 0.1176 |
6894 | TARBP1 | A001-C-207 | Human | Colorectum | FAP | 7.13e-04 | -3.70e-01 | 0.1278 |
6894 | TARBP1 | A015-C-203 | Human | Colorectum | FAP | 4.90e-28 | -4.62e-01 | -0.1294 |
6894 | TARBP1 | A015-C-204 | Human | Colorectum | FAP | 1.41e-05 | -3.64e-01 | -0.0228 |
6894 | TARBP1 | A002-C-201 | Human | Colorectum | FAP | 1.27e-11 | -4.17e-01 | 0.0324 |
6894 | TARBP1 | A001-C-119 | Human | Colorectum | FAP | 5.12e-04 | -3.92e-01 | -0.1557 |
6894 | TARBP1 | A001-C-108 | Human | Colorectum | FAP | 2.10e-14 | -2.74e-01 | -0.0272 |
6894 | TARBP1 | A002-C-205 | Human | Colorectum | FAP | 2.00e-18 | -3.93e-01 | -0.1236 |
6894 | TARBP1 | A001-C-104 | Human | Colorectum | FAP | 2.84e-04 | -1.87e-01 | 0.0184 |
6894 | TARBP1 | A015-C-006 | Human | Colorectum | FAP | 2.90e-09 | -1.70e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TARBP1 | SNV | Missense_Mutation | novel | c.3670N>G | p.Gln1224Glu | p.Q1224E | Q13395 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
TARBP1 | deletion | Frame_Shift_Del | novel | c.2675_2690delNNNNNNNNNNNNNNNN | p.Gln892LeufsTer4 | p.Q892Lfs*4 | Q13395 | protein_coding | TCGA-CV-5970-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
TARBP1 | SNV | Missense_Mutation | rs201389692 | c.4013N>A | p.Arg1338His | p.R1338H | Q13395 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-VP-A879-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
TARBP1 | SNV | Missense_Mutation | novel | c.4071G>T | p.Glu1357Asp | p.E1357D | Q13395 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TARBP1 | SNV | Missense_Mutation | rs766128155 | c.3461A>C | p.Lys1154Thr | p.K1154T | Q13395 | protein_coding | deleterious(0) | benign(0.212) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
TARBP1 | SNV | Missense_Mutation | c.2370N>A | p.His790Gln | p.H790Q | Q13395 | protein_coding | tolerated(0.2) | benign(0.425) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TARBP1 | SNV | Missense_Mutation | c.3913N>C | p.Ser1305Arg | p.S1305R | Q13395 | protein_coding | tolerated(0.57) | benign(0) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TARBP1 | SNV | Missense_Mutation | novel | c.4835A>T | p.Gln1612Leu | p.Q1612L | Q13395 | protein_coding | deleterious(0.01) | benign(0.024) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
TARBP1 | SNV | Missense_Mutation | c.1218G>T | p.Lys406Asn | p.K406N | Q13395 | protein_coding | deleterious(0.04) | benign(0.109) | TCGA-CD-5798-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TARBP1 | SNV | Missense_Mutation | c.4585T>C | p.Tyr1529His | p.Y1529H | Q13395 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-CG-4466-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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