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Gene: TAF3 |
Gene summary for TAF3 |
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Gene information | Species | Human | Gene symbol | TAF3 | Gene ID | 83860 |
Gene name | TATA-box binding protein associated factor 3 | |
Gene Alias | TAF140 | |
Cytomap | 10p14 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q5VWG9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83860 | TAF3 | CCI_2 | Human | Cervix | CC | 4.29e-10 | 1.15e+00 | 0.5249 |
83860 | TAF3 | CCI_3 | Human | Cervix | CC | 1.90e-05 | 6.18e-01 | 0.516 |
83860 | TAF3 | LZE4T | Human | Esophagus | ESCC | 3.05e-08 | 2.71e-01 | 0.0811 |
83860 | TAF3 | LZE5T | Human | Esophagus | ESCC | 2.84e-03 | 1.69e-01 | 0.0514 |
83860 | TAF3 | LZE7T | Human | Esophagus | ESCC | 4.08e-05 | 2.01e-01 | 0.0667 |
83860 | TAF3 | LZE8T | Human | Esophagus | ESCC | 3.93e-02 | 6.15e-02 | 0.067 |
83860 | TAF3 | LZE22T | Human | Esophagus | ESCC | 2.02e-03 | 1.69e-01 | 0.068 |
83860 | TAF3 | LZE24T | Human | Esophagus | ESCC | 5.29e-15 | 3.38e-01 | 0.0596 |
83860 | TAF3 | LZE21T | Human | Esophagus | ESCC | 1.65e-04 | 2.39e-01 | 0.0655 |
83860 | TAF3 | LZE6T | Human | Esophagus | ESCC | 3.99e-04 | 1.05e-01 | 0.0845 |
83860 | TAF3 | P1T-E | Human | Esophagus | ESCC | 1.78e-02 | 2.65e-01 | 0.0875 |
83860 | TAF3 | P2T-E | Human | Esophagus | ESCC | 7.28e-25 | 3.67e-01 | 0.1177 |
83860 | TAF3 | P4T-E | Human | Esophagus | ESCC | 2.61e-21 | 3.77e-01 | 0.1323 |
83860 | TAF3 | P5T-E | Human | Esophagus | ESCC | 2.10e-18 | 2.34e-01 | 0.1327 |
83860 | TAF3 | P8T-E | Human | Esophagus | ESCC | 4.47e-11 | 2.59e-01 | 0.0889 |
83860 | TAF3 | P9T-E | Human | Esophagus | ESCC | 6.35e-08 | 2.01e-01 | 0.1131 |
83860 | TAF3 | P10T-E | Human | Esophagus | ESCC | 4.84e-13 | 1.61e-01 | 0.116 |
83860 | TAF3 | P11T-E | Human | Esophagus | ESCC | 9.29e-08 | 1.83e-01 | 0.1426 |
83860 | TAF3 | P12T-E | Human | Esophagus | ESCC | 2.49e-20 | 5.30e-01 | 0.1122 |
83860 | TAF3 | P15T-E | Human | Esophagus | ESCC | 2.89e-18 | 3.32e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00325077 | Cervix | CC | maintenance of protein location in cell | 21/2311 | 65/18723 | 2.03e-05 | 3.71e-04 | 21 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:00725955 | Cervix | CC | maintenance of protein localization in organelle | 14/2311 | 42/18723 | 3.32e-04 | 3.49e-03 | 14 |
GO:00514571 | Cervix | CC | maintenance of protein location in nucleus | 8/2311 | 23/18723 | 4.70e-03 | 2.82e-02 | 8 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:0045185111 | Esophagus | ESCC | maintenance of protein location | 71/8552 | 94/18723 | 3.41e-09 | 7.24e-08 | 71 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:0032507110 | Esophagus | ESCC | maintenance of protein location in cell | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:007259517 | Esophagus | ESCC | maintenance of protein localization in organelle | 36/8552 | 42/18723 | 8.46e-08 | 1.44e-06 | 36 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:005145712 | Esophagus | ESCC | maintenance of protein location in nucleus | 20/8552 | 23/18723 | 4.97e-05 | 3.86e-04 | 20 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:00434332 | Esophagus | ESCC | negative regulation of DNA-binding transcription factor activity | 103/8552 | 185/18723 | 3.86e-03 | 1.57e-02 | 103 |
GO:003450411 | Liver | Cirrhotic | protein localization to nucleus | 113/4634 | 290/18723 | 5.00e-08 | 1.58e-06 | 113 |
GO:00451857 | Liver | Cirrhotic | maintenance of protein location | 46/4634 | 94/18723 | 3.31e-07 | 7.90e-06 | 46 |
GO:00325074 | Liver | Cirrhotic | maintenance of protein location in cell | 35/4634 | 65/18723 | 4.60e-07 | 1.05e-05 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa03022 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
hsa030221 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAF3 | deletion | Frame_Shift_Del | novel | c.1638delA | p.Asp547ThrfsTer13 | p.D547Tfs*13 | Q5VWG9 | protein_coding | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
TAF3 | insertion | Frame_Shift_Ins | rs754261495 | c.1863_1864insTTCCTTCCAG | p.Asp622PhefsTer5 | p.D622Ffs*5 | Q5VWG9 | protein_coding | TCGA-BR-8676-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
TAF3 | deletion | Frame_Shift_Del | novel | c.1580delA | p.Lys527ArgfsTer3 | p.K527Rfs*3 | Q5VWG9 | protein_coding | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
TAF3 | insertion | Frame_Shift_Ins | novel | c.1863_1864insTTCCTTCCAGG | p.Asp622PhefsTer21 | p.D622Ffs*21 | Q5VWG9 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
TAF3 | insertion | Frame_Shift_Ins | novel | c.1634_1635insGGAG | p.Lys546GlufsTer10 | p.K546Efs*10 | Q5VWG9 | protein_coding | TCGA-IM-A41Z-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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