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Gene: SYDE2 |
Gene summary for SYDE2 |
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Gene information | Species | Human | Gene symbol | SYDE2 | Gene ID | 84144 |
Gene name | synapse defective Rho GTPase homolog 2 | |
Gene Alias | SYDE2 | |
Cytomap | 1p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q5VT97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84144 | SYDE2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.47e-16 | 5.80e-01 | -0.0166 |
84144 | SYDE2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.85e-15 | 5.34e-01 | -0.0132 |
84144 | SYDE2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.57e-15 | 4.77e-01 | -0.013 |
84144 | SYDE2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.13e-12 | 4.88e-01 | -0.0121 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510565 | Lung | IAC | regulation of small GTPase mediated signal transduction | 70/2061 | 302/18723 | 9.44e-10 | 1.87e-07 | 70 |
GO:00430876 | Lung | IAC | regulation of GTPase activity | 67/2061 | 348/18723 | 3.43e-06 | 1.44e-04 | 67 |
GO:00435475 | Lung | IAC | positive regulation of GTPase activity | 48/2061 | 255/18723 | 1.40e-04 | 2.60e-03 | 48 |
GO:00906303 | Lung | IAC | activation of GTPase activity | 22/2061 | 115/18723 | 6.80e-03 | 4.73e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYDE2 | SNV | Missense_Mutation | novel | c.2483N>A | p.Gly828Glu | p.G828E | Q5VT97 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-CV-6960-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
SYDE2 | SNV | Missense_Mutation | novel | c.3368N>T | p.Gly1123Val | p.G1123V | Q5VT97 | protein_coding | deleterious(0.03) | benign(0.215) | TCGA-CV-A6JO-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SYDE2 | SNV | Missense_Mutation | c.1438N>T | p.Ala480Ser | p.A480S | Q5VT97 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-QK-A6V9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SYDE2 | insertion | Frame_Shift_Ins | novel | c.874_875insT | p.Tyr292LeufsTer9 | p.Y292Lfs*9 | Q5VT97 | protein_coding | TCGA-CV-7102-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SYDE2 | insertion | Nonsense_Mutation | novel | c.1659_1660insTAGCTTTAGTTGTA | p.Ser554Ter | p.S554* | Q5VT97 | protein_coding | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
SYDE2 | SNV | Missense_Mutation | novel | c.1717G>A | p.Asp573Asn | p.D573N | Q5VT97 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-TP-A8TV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
SYDE2 | SNV | Missense_Mutation | c.2857N>T | p.Thr953Ser | p.T953S | Q5VT97 | protein_coding | tolerated(0.06) | possibly_damaging(0.461) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SYDE2 | SNV | Missense_Mutation | c.848N>T | p.Thr283Ile | p.T283I | Q5VT97 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.927) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
SYDE2 | SNV | Missense_Mutation | c.3356N>T | p.Asp1119Val | p.D1119V | Q5VT97 | protein_coding | deleterious(0) | possibly_damaging(0.603) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
SYDE2 | SNV | Missense_Mutation | novel | c.557N>C | p.Val186Ala | p.V186A | Q5VT97 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.551) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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