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Gene: STAU2 |
Gene summary for STAU2 |
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Gene information | Species | Human | Gene symbol | STAU2 | Gene ID | 27067 |
Gene name | staufen double-stranded RNA binding protein 2 | |
Gene Alias | 39K2 | |
Cytomap | 8q21.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A0A0MTC5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27067 | STAU2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.19e-07 | -3.95e-01 | 0.0155 |
27067 | STAU2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.06e-02 | -3.29e-01 | -0.1808 |
27067 | STAU2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.21e-02 | -2.74e-01 | -0.1464 |
27067 | STAU2 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.04e-05 | -4.03e-01 | 0.096 |
27067 | STAU2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.87e-14 | -4.35e-01 | 0.0674 |
27067 | STAU2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.75e-06 | -3.70e-01 | 0.294 |
27067 | STAU2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.47e-08 | -3.76e-01 | 0.3005 |
27067 | STAU2 | A015-C-203 | Human | Colorectum | FAP | 1.87e-23 | -3.58e-01 | -0.1294 |
27067 | STAU2 | A015-C-204 | Human | Colorectum | FAP | 2.48e-05 | -2.54e-01 | -0.0228 |
27067 | STAU2 | A002-C-201 | Human | Colorectum | FAP | 1.36e-08 | -1.87e-01 | 0.0324 |
27067 | STAU2 | A001-C-119 | Human | Colorectum | FAP | 5.03e-07 | -3.70e-01 | -0.1557 |
27067 | STAU2 | A001-C-108 | Human | Colorectum | FAP | 1.77e-14 | -3.72e-01 | -0.0272 |
27067 | STAU2 | A002-C-205 | Human | Colorectum | FAP | 3.69e-20 | -4.77e-01 | -0.1236 |
27067 | STAU2 | A001-C-104 | Human | Colorectum | FAP | 4.95e-04 | -2.95e-01 | 0.0184 |
27067 | STAU2 | A015-C-005 | Human | Colorectum | FAP | 8.73e-04 | -2.67e-01 | -0.0336 |
27067 | STAU2 | A015-C-006 | Human | Colorectum | FAP | 2.39e-15 | -5.24e-01 | -0.0994 |
27067 | STAU2 | A015-C-106 | Human | Colorectum | FAP | 2.38e-08 | -2.17e-01 | -0.0511 |
27067 | STAU2 | A002-C-114 | Human | Colorectum | FAP | 6.29e-15 | -4.08e-01 | -0.1561 |
27067 | STAU2 | A015-C-104 | Human | Colorectum | FAP | 4.54e-26 | -3.39e-01 | -0.1899 |
27067 | STAU2 | A001-C-014 | Human | Colorectum | FAP | 1.64e-13 | -3.05e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAU2 | deletion | Frame_Shift_Del | rs770360338 | c.1091delN | p.Asn364MetfsTer67 | p.N364Mfs*67 | protein_coding | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
STAU2 | deletion | Frame_Shift_Del | rs770360338 | c.1091delN | p.Asn364MetfsTer67 | p.N364Mfs*67 | protein_coding | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
STAU2 | deletion | Frame_Shift_Del | novel | c.1090_1091delNN | p.Asn364CysfsTer12 | p.N364Cfs*12 | protein_coding | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR | |||
STAU2 | insertion | Frame_Shift_Ins | novel | c.1228_1229insT | p.Lys410IlefsTer9 | p.K410Ifs*9 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |||
STAU2 | insertion | In_Frame_Ins | novel | c.1227_1228insTTC | p.Pro409_Lys410insPhe | p.P409_K410insF | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |||
STAU2 | insertion | Frame_Shift_Ins | novel | c.1337_1338insTTCAT | p.Gln446HisfsTer27 | p.Q446Hfs*27 | protein_coding | TCGA-EL-A3ZH-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
STAU2 | insertion | Frame_Shift_Ins | novel | c.1228_1229insT | p.Lys410IlefsTer9 | p.K410Ifs*9 | protein_coding | TCGA-EL-A3ZP-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
STAU2 | insertion | In_Frame_Ins | novel | c.1227_1228insTTC | p.Pro409_Lys410insPhe | p.P409_K410insF | protein_coding | TCGA-EL-A3ZP-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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