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Gene: SBNO1 |
Gene summary for SBNO1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SBNO1 | Gene ID | 55206 |
Gene name | strawberry notch homolog 1 | |
Gene Alias | MOP3 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A3KN83 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55206 | SBNO1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.62e-04 | -2.86e-01 | 0.0155 |
55206 | SBNO1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.48e-04 | 4.05e-01 | -0.1954 |
55206 | SBNO1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.40e-04 | 9.91e-01 | 0.3487 |
55206 | SBNO1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.36e-05 | 6.22e-01 | 0.281 |
55206 | SBNO1 | A001-C-207 | Human | Colorectum | FAP | 4.28e-02 | -1.85e-01 | 0.1278 |
55206 | SBNO1 | A015-C-203 | Human | Colorectum | FAP | 9.90e-12 | -2.19e-01 | -0.1294 |
55206 | SBNO1 | A015-C-204 | Human | Colorectum | FAP | 2.72e-03 | -1.36e-01 | -0.0228 |
55206 | SBNO1 | A002-C-201 | Human | Colorectum | FAP | 1.87e-07 | -1.22e-01 | 0.0324 |
55206 | SBNO1 | A001-C-108 | Human | Colorectum | FAP | 1.02e-04 | 3.08e-02 | -0.0272 |
55206 | SBNO1 | A002-C-205 | Human | Colorectum | FAP | 2.53e-10 | -2.13e-02 | -0.1236 |
55206 | SBNO1 | A015-C-006 | Human | Colorectum | FAP | 2.88e-08 | 5.28e-02 | -0.0994 |
55206 | SBNO1 | A015-C-106 | Human | Colorectum | FAP | 1.16e-02 | -2.05e-03 | -0.0511 |
55206 | SBNO1 | A002-C-114 | Human | Colorectum | FAP | 4.09e-11 | -2.65e-01 | -0.1561 |
55206 | SBNO1 | A015-C-104 | Human | Colorectum | FAP | 3.94e-12 | -1.13e-01 | -0.1899 |
55206 | SBNO1 | A001-C-014 | Human | Colorectum | FAP | 1.35e-04 | -8.35e-02 | 0.0135 |
55206 | SBNO1 | A002-C-016 | Human | Colorectum | FAP | 7.38e-10 | -1.58e-01 | 0.0521 |
55206 | SBNO1 | A015-C-002 | Human | Colorectum | FAP | 2.19e-06 | -2.01e-01 | -0.0763 |
55206 | SBNO1 | A002-C-116 | Human | Colorectum | FAP | 1.09e-15 | -1.20e-01 | -0.0452 |
55206 | SBNO1 | A014-C-008 | Human | Colorectum | FAP | 9.28e-06 | -1.01e-01 | -0.191 |
55206 | SBNO1 | A018-E-020 | Human | Colorectum | FAP | 1.79e-11 | -2.14e-01 | -0.2034 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SBNO1 | insertion | In_Frame_Ins | novel | c.2365_2366insCAGTATTTC | p.Lys789delinsThrValPheGln | p.K789delinsTVFQ | A3KN83 | protein_coding | TCGA-MP-A4T6-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SBNO1 | SNV | Missense_Mutation | novel | c.237G>T | p.Arg79Ser | p.R79S | A3KN83 | protein_coding | deleterious_low_confidence(0.01) | benign(0.055) | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SBNO1 | SNV | Missense_Mutation | novel | c.2792G>C | p.Gly931Ala | p.G931A | A3KN83 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
SBNO1 | SNV | Missense_Mutation | novel | c.2545G>A | p.Glu849Lys | p.E849K | A3KN83 | protein_coding | tolerated(0.08) | possibly_damaging(0.453) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
SBNO1 | SNV | Missense_Mutation | novel | c.4069N>T | p.Pro1357Ser | p.P1357S | A3KN83 | protein_coding | tolerated(0.73) | benign(0.001) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
SBNO1 | SNV | Missense_Mutation | c.1330T>G | p.Leu444Val | p.L444V | A3KN83 | protein_coding | tolerated(0.13) | benign(0.072) | TCGA-CV-7415-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SBNO1 | SNV | Missense_Mutation | novel | c.1435N>T | p.Ala479Ser | p.A479S | A3KN83 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SBNO1 | SNV | Missense_Mutation | novel | c.1898N>G | p.Ser633Cys | p.S633C | A3KN83 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
SBNO1 | SNV | Missense_Mutation | novel | c.1645N>T | p.Leu549Phe | p.L549F | A3KN83 | protein_coding | deleterious(0) | benign(0.027) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
SBNO1 | SNV | Missense_Mutation | novel | c.154N>A | p.Glu52Lys | p.E52K | A3KN83 | protein_coding | tolerated_low_confidence(0.18) | benign(0.017) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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