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Gene: SAMD9L |
Gene summary for SAMD9L |
Gene summary. |
Gene information | Species | Human | Gene symbol | SAMD9L | Gene ID | 219285 |
Gene name | sterile alpha motif domain containing 9 like | |
Gene Alias | ATXPC | |
Cytomap | 7q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IVG5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219285 | SAMD9L | LZE20T | Human | Esophagus | ESCC | 1.23e-07 | 4.05e-01 | 0.0662 |
219285 | SAMD9L | LZE24T | Human | Esophagus | ESCC | 3.89e-13 | 5.14e-01 | 0.0596 |
219285 | SAMD9L | LZE6T | Human | Esophagus | ESCC | 7.85e-03 | 1.84e-01 | 0.0845 |
219285 | SAMD9L | P1T-E | Human | Esophagus | ESCC | 7.11e-03 | 2.91e-01 | 0.0875 |
219285 | SAMD9L | P2T-E | Human | Esophagus | ESCC | 6.71e-22 | 4.45e-01 | 0.1177 |
219285 | SAMD9L | P5T-E | Human | Esophagus | ESCC | 2.10e-04 | 7.25e-02 | 0.1327 |
219285 | SAMD9L | P8T-E | Human | Esophagus | ESCC | 7.57e-18 | 4.06e-01 | 0.0889 |
219285 | SAMD9L | P9T-E | Human | Esophagus | ESCC | 1.16e-05 | 1.85e-01 | 0.1131 |
219285 | SAMD9L | P11T-E | Human | Esophagus | ESCC | 2.78e-10 | 5.46e-01 | 0.1426 |
219285 | SAMD9L | P20T-E | Human | Esophagus | ESCC | 1.15e-08 | 3.43e-01 | 0.1124 |
219285 | SAMD9L | P21T-E | Human | Esophagus | ESCC | 6.14e-07 | 2.19e-01 | 0.1617 |
219285 | SAMD9L | P23T-E | Human | Esophagus | ESCC | 1.07e-09 | 3.13e-01 | 0.108 |
219285 | SAMD9L | P24T-E | Human | Esophagus | ESCC | 4.29e-08 | 2.13e-01 | 0.1287 |
219285 | SAMD9L | P26T-E | Human | Esophagus | ESCC | 1.52e-02 | 9.21e-02 | 0.1276 |
219285 | SAMD9L | P27T-E | Human | Esophagus | ESCC | 3.90e-02 | 8.13e-02 | 0.1055 |
219285 | SAMD9L | P32T-E | Human | Esophagus | ESCC | 1.11e-05 | 1.54e-01 | 0.1666 |
219285 | SAMD9L | P36T-E | Human | Esophagus | ESCC | 3.06e-10 | 4.68e-01 | 0.1187 |
219285 | SAMD9L | P37T-E | Human | Esophagus | ESCC | 3.66e-06 | 2.04e-01 | 0.1371 |
219285 | SAMD9L | P40T-E | Human | Esophagus | ESCC | 5.80e-06 | 2.47e-01 | 0.109 |
219285 | SAMD9L | P47T-E | Human | Esophagus | ESCC | 2.30e-07 | 1.46e-01 | 0.1067 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAMD9L | SNV | Missense_Mutation | novel | c.193N>A | p.Ala65Thr | p.A65T | Q8IVG5 | protein_coding | deleterious(0.03) | possibly_damaging(0.61) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.4748N>C | p.Val1583Ala | p.V1583A | Q8IVG5 | protein_coding | tolerated(0.24) | benign(0.006) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.938N>G | p.His313Arg | p.H313R | Q8IVG5 | protein_coding | deleterious(0.01) | possibly_damaging(0.563) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.2665T>A | p.Phe889Ile | p.F889I | Q8IVG5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.230G>T | p.Ser77Ile | p.S77I | Q8IVG5 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | c.2014G>A | p.Asp672Asn | p.D672N | Q8IVG5 | protein_coding | tolerated(0.17) | benign(0.024) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SAMD9L | SNV | Missense_Mutation | novel | c.967A>G | p.Ile323Val | p.I323V | Q8IVG5 | protein_coding | tolerated(0.24) | benign(0.015) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | c.3493N>A | p.Glu1165Lys | p.E1165K | Q8IVG5 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAMD9L | SNV | Missense_Mutation | c.3054N>T | p.Glu1018Asp | p.E1018D | Q8IVG5 | protein_coding | tolerated(0.13) | possibly_damaging(0.797) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAMD9L | SNV | Missense_Mutation | rs375447430 | c.2461N>A | p.Val821Ile | p.V821I | Q8IVG5 | protein_coding | tolerated(0.18) | benign(0) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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