GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:00712601 | Liver | HCC | cellular response to mechanical stimulus | 48/7958 | 81/18723 | 1.72e-03 | 8.96e-03 | 48 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:0071496113 | Thyroid | PTC | cellular response to external stimulus | 158/5968 | 320/18723 | 4.12e-11 | 1.47e-09 | 158 |
GO:0071214111 | Thyroid | PTC | cellular response to abiotic stimulus | 158/5968 | 331/18723 | 9.90e-10 | 2.89e-08 | 158 |
GO:0104004111 | Thyroid | PTC | cellular response to environmental stimulus | 158/5968 | 331/18723 | 9.90e-10 | 2.89e-08 | 158 |
GO:0009612110 | Thyroid | PTC | response to mechanical stimulus | 98/5968 | 216/18723 | 2.09e-05 | 2.09e-04 | 98 |
GO:007126016 | Thyroid | PTC | cellular response to mechanical stimulus | 44/5968 | 81/18723 | 2.34e-05 | 2.33e-04 | 44 |
GO:0071496210 | Thyroid | ATC | cellular response to external stimulus | 165/6293 | 320/18723 | 2.01e-11 | 7.23e-10 | 165 |
GO:007121427 | Thyroid | ATC | cellular response to abiotic stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:010400427 | Thyroid | ATC | cellular response to environmental stimulus | 169/6293 | 331/18723 | 3.24e-11 | 1.08e-09 | 169 |
GO:000961225 | Thyroid | ATC | response to mechanical stimulus | 105/6293 | 216/18723 | 3.29e-06 | 3.70e-05 | 105 |
GO:007126022 | Thyroid | ATC | cellular response to mechanical stimulus | 46/6293 | 81/18723 | 1.51e-05 | 1.41e-04 | 46 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIEZO2 | SNV | Missense_Mutation | novel | c.3149C>A | p.Ser1050Tyr | p.S1050Y | Q9H5I5 | protein_coding | tolerated(1) | benign(0.243) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.1357G>A | p.Glu453Lys | p.E453K | Q9H5I5 | protein_coding | tolerated(0.21) | benign(0.028) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.1018C>A | p.Leu340Ile | p.L340I | Q9H5I5 | protein_coding | tolerated(0.65) | benign(0.01) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.603C>A | p.Phe201Leu | p.F201L | Q9H5I5 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.6245N>T | p.Ser2082Leu | p.S2082L | Q9H5I5 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.2497N>A | p.Ala833Thr | p.A833T | Q9H5I5 | protein_coding | tolerated(0.15) | benign(0.012) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.3763N>A | p.Ala1255Thr | p.A1255T | Q9H5I5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.2120N>G | p.Tyr707Cys | p.Y707C | Q9H5I5 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.7922A>G | p.Tyr2641Cys | p.Y2641C | Q9H5I5 | protein_coding | tolerated(0.2) | benign(0.312) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PIEZO2 | SNV | Missense_Mutation | novel | c.5245T>G | p.Ser1749Ala | p.S1749A | Q9H5I5 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |