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Gene: PDZRN4 |
Gene summary for PDZRN4 |
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Gene information | Species | Human | Gene symbol | PDZRN4 | Gene ID | 29951 |
Gene name | PDZ domain containing ring finger 4 | |
Gene Alias | LNX4 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B4DGD1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29951 | PDZRN4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.88e-04 | 1.77e-01 | 0.0155 |
29951 | PDZRN4 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.59e-03 | 1.74e-01 | -0.1954 |
29951 | PDZRN4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.27e-03 | 1.61e-01 | -0.1207 |
29951 | PDZRN4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.66e-04 | 1.46e-01 | -0.1464 |
29951 | PDZRN4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.94e-04 | 2.35e-01 | -0.059 |
29951 | PDZRN4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.25e-03 | 3.90e-01 | -0.1706 |
29951 | PDZRN4 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.42e-04 | 2.15e-01 | -0.0842 |
29951 | PDZRN4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.33e-82 | 3.95e+00 | 0.281 |
29951 | PDZRN4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.21e-19 | 5.26e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDZRN4 | SNV | Missense_Mutation | c.2894N>A | p.Arg965Gln | p.R965Q | Q6ZMN7 | protein_coding | tolerated(1) | benign(0.226) | TCGA-05-5715-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDZRN4 | SNV | Missense_Mutation | novel | c.2812N>T | p.Gly938Trp | p.G938W | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-38-4627-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDZRN4 | SNV | Missense_Mutation | novel | c.749G>A | p.Gly250Glu | p.G250E | Q6ZMN7 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-38-4628-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
PDZRN4 | SNV | Missense_Mutation | c.649N>C | p.Asp217His | p.D217H | Q6ZMN7 | protein_coding | tolerated_low_confidence(0.06) | benign(0.062) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
PDZRN4 | SNV | Missense_Mutation | c.2687N>G | p.Asp896Gly | p.D896G | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-A479-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PDZRN4 | SNV | Missense_Mutation | c.2140A>T | p.Ile714Leu | p.I714L | Q6ZMN7 | protein_coding | tolerated(0.65) | benign(0) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDZRN4 | SNV | Missense_Mutation | novel | c.1373N>C | p.Gly458Ala | p.G458A | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR |
PDZRN4 | SNV | Missense_Mutation | c.2460G>T | p.Glu820Asp | p.E820D | Q6ZMN7 | protein_coding | tolerated(0.47) | benign(0.001) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
PDZRN4 | SNV | Missense_Mutation | novel | c.2543G>T | p.Arg848Leu | p.R848L | Q6ZMN7 | protein_coding | deleterious(0) | benign(0.194) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDZRN4 | SNV | Missense_Mutation | rs775748827 | c.2035G>C | p.Glu679Gln | p.E679Q | Q6ZMN7 | protein_coding | deleterious(0) | possibly_damaging(0.684) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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