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Gene: OXR1 |
Gene summary for OXR1 |
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Gene information | Species | Human | Gene symbol | OXR1 | Gene ID | 55074 |
Gene name | oxidation resistance 1 | |
Gene Alias | CHEGDD | |
Cytomap | 8q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N573 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55074 | OXR1 | CA_HPV_3 | Human | Cervix | CC | 1.09e-03 | 9.66e-02 | 0.0414 |
55074 | OXR1 | CCI_1 | Human | Cervix | CC | 5.66e-04 | 7.60e-01 | 0.528 |
55074 | OXR1 | CCI_2 | Human | Cervix | CC | 9.61e-05 | 1.36e+00 | 0.5249 |
55074 | OXR1 | CCI_3 | Human | Cervix | CC | 2.05e-04 | 5.72e-01 | 0.516 |
55074 | OXR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.68e-20 | -6.50e-01 | 0.0155 |
55074 | OXR1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.57e-03 | -7.23e-01 | 0.0216 |
55074 | OXR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.96e-07 | -2.91e-01 | -0.1001 |
55074 | OXR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.61e-06 | -4.77e-01 | 0.096 |
55074 | OXR1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.09e-03 | -6.10e-01 | 0.0528 |
55074 | OXR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.00e-08 | -3.59e-01 | 0.0674 |
55074 | OXR1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.25e-04 | -3.97e-01 | 0.0112 |
55074 | OXR1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.27e-08 | -5.92e-01 | 0.0588 |
55074 | OXR1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.99e-03 | -4.91e-01 | 0.2585 |
55074 | OXR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.73e-22 | -6.05e-01 | 0.3005 |
55074 | OXR1 | F007 | Human | Colorectum | FAP | 1.04e-05 | -3.59e-01 | 0.1176 |
55074 | OXR1 | A002-C-010 | Human | Colorectum | FAP | 3.11e-04 | -2.28e-01 | 0.242 |
55074 | OXR1 | A001-C-207 | Human | Colorectum | FAP | 1.01e-06 | -3.23e-01 | 0.1278 |
55074 | OXR1 | A015-C-203 | Human | Colorectum | FAP | 1.91e-40 | -5.46e-01 | -0.1294 |
55074 | OXR1 | A015-C-204 | Human | Colorectum | FAP | 7.77e-12 | -4.53e-01 | -0.0228 |
55074 | OXR1 | A014-C-040 | Human | Colorectum | FAP | 1.31e-08 | -6.05e-01 | -0.1184 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:006219710 | Cervix | CC | cellular response to chemical stress | 76/2311 | 337/18723 | 1.01e-07 | 5.25e-06 | 76 |
GO:003459910 | Cervix | CC | cellular response to oxidative stress | 63/2311 | 288/18723 | 3.58e-06 | 9.50e-05 | 63 |
GO:007099710 | Cervix | CC | neuron death | 70/2311 | 361/18723 | 7.50e-05 | 1.03e-03 | 70 |
GO:190121410 | Cervix | CC | regulation of neuron death | 61/2311 | 319/18723 | 3.11e-04 | 3.31e-03 | 61 |
GO:005140210 | Cervix | CC | neuron apoptotic process | 49/2311 | 246/18723 | 4.48e-04 | 4.48e-03 | 49 |
GO:00170143 | Cervix | CC | protein nitrosylation | 7/2311 | 16/18723 | 1.79e-03 | 1.34e-02 | 7 |
GO:00181193 | Cervix | CC | peptidyl-cysteine S-nitrosylation | 7/2311 | 16/18723 | 1.79e-03 | 1.34e-02 | 7 |
GO:00435238 | Cervix | CC | regulation of neuron apoptotic process | 41/2311 | 212/18723 | 2.23e-03 | 1.60e-02 | 41 |
GO:003647310 | Cervix | CC | cell death in response to oxidative stress | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
GO:0036473 | Colorectum | AD | cell death in response to oxidative stress | 35/3918 | 95/18723 | 2.58e-04 | 3.24e-03 | 35 |
GO:1903203 | Colorectum | AD | regulation of oxidative stress-induced neuron death | 14/3918 | 27/18723 | 3.72e-04 | 4.29e-03 | 14 |
GO:1903204 | Colorectum | AD | negative regulation of oxidative stress-induced neuron death | 11/3918 | 19/18723 | 4.66e-04 | 5.15e-03 | 11 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OXR1 | SNV | Missense_Mutation | novel | c.2094N>G | p.Asp698Glu | p.D698E | Q8N573 | protein_coding | tolerated(0.57) | benign(0.012) | TCGA-60-2704-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxotere | PD |
OXR1 | SNV | Missense_Mutation | c.1568N>G | p.Gln523Arg | p.Q523R | Q8N573 | protein_coding | tolerated(0.26) | benign(0.218) | TCGA-70-6723-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OXR1 | SNV | Missense_Mutation | novel | c.436N>A | p.Glu146Lys | p.E146K | Q8N573 | protein_coding | deleterious(0.04) | benign(0.219) | TCGA-98-8020-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
OXR1 | SNV | Missense_Mutation | novel | c.1165N>T | p.Thr389Ser | p.T389S | Q8N573 | protein_coding | tolerated(0.82) | benign(0) | TCGA-NC-A5HD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OXR1 | SNV | Missense_Mutation | rs765153986 | c.868A>G | p.Ile290Val | p.I290V | Q8N573 | protein_coding | tolerated(0.48) | benign(0) | TCGA-NK-A5CR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OXR1 | SNV | Missense_Mutation | novel | c.835N>A | p.Asp279Asn | p.D279N | Q8N573 | protein_coding | tolerated(0.29) | benign(0.085) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
OXR1 | SNV | Missense_Mutation | novel | c.2597N>G | p.Gln866Arg | p.Q866R | Q8N573 | protein_coding | tolerated(0.05) | benign(0.133) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
OXR1 | SNV | Missense_Mutation | c.1612N>A | p.Asp538Asn | p.D538N | Q8N573 | protein_coding | tolerated(0.09) | possibly_damaging(0.529) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OXR1 | SNV | Missense_Mutation | rs541833758 | c.266N>A | p.Arg89Gln | p.R89Q | Q8N573 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OXR1 | SNV | Missense_Mutation | c.346N>C | p.Phe116Leu | p.F116L | Q8N573 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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