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Gene: NISCH |
Gene summary for NISCH |
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Gene information | Species | Human | Gene symbol | NISCH | Gene ID | 11188 |
Gene name | nischarin | |
Gene Alias | I-1 | |
Cytomap | 3p21.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y2I1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11188 | NISCH | HCC1_Meng | Human | Liver | HCC | 3.05e-23 | 2.82e-02 | 0.0246 |
11188 | NISCH | HCC1 | Human | Liver | HCC | 7.48e-08 | 4.59e+00 | 0.5336 |
11188 | NISCH | HCC2 | Human | Liver | HCC | 6.29e-07 | 3.20e+00 | 0.5341 |
11188 | NISCH | S014 | Human | Liver | HCC | 1.26e-05 | 4.53e-01 | 0.2254 |
11188 | NISCH | S015 | Human | Liver | HCC | 2.84e-09 | 6.23e-01 | 0.2375 |
11188 | NISCH | S028 | Human | Liver | HCC | 5.38e-12 | 6.70e-01 | 0.2503 |
11188 | NISCH | S029 | Human | Liver | HCC | 2.47e-05 | 4.60e-01 | 0.2581 |
11188 | NISCH | C04 | Human | Oral cavity | OSCC | 6.44e-06 | 2.93e-01 | 0.2633 |
11188 | NISCH | C21 | Human | Oral cavity | OSCC | 6.32e-12 | 2.67e-01 | 0.2678 |
11188 | NISCH | C30 | Human | Oral cavity | OSCC | 5.69e-14 | 6.23e-01 | 0.3055 |
11188 | NISCH | C46 | Human | Oral cavity | OSCC | 1.56e-07 | 2.48e-01 | 0.1673 |
11188 | NISCH | C51 | Human | Oral cavity | OSCC | 1.87e-04 | 3.69e-01 | 0.2674 |
11188 | NISCH | C09 | Human | Oral cavity | OSCC | 3.95e-02 | 7.88e-02 | 0.1431 |
11188 | NISCH | LN22 | Human | Oral cavity | OSCC | 1.81e-05 | 6.10e-01 | 0.1733 |
11188 | NISCH | SYSMH2 | Human | Oral cavity | OSCC | 1.69e-04 | 2.14e-01 | 0.2326 |
11188 | NISCH | SYSMH3 | Human | Oral cavity | OSCC | 1.43e-11 | 3.92e-01 | 0.2442 |
11188 | NISCH | SYSMH6 | Human | Oral cavity | OSCC | 1.46e-02 | 1.26e-01 | 0.1275 |
11188 | NISCH | HTA12-25-1 | Human | Pancreas | PDAC | 9.69e-04 | 4.55e-01 | 0.313 |
11188 | NISCH | HTA12-26-1 | Human | Pancreas | PDAC | 7.87e-28 | 1.05e+00 | 0.3728 |
11188 | NISCH | HTA12-29-1 | Human | Pancreas | PDAC | 4.59e-51 | 1.02e+00 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:001931821 | Liver | HCC | hexose metabolic process | 155/7958 | 237/18723 | 7.63e-13 | 3.90e-11 | 155 |
GO:000600621 | Liver | HCC | glucose metabolic process | 128/7958 | 196/18723 | 8.60e-11 | 3.06e-09 | 128 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:001660121 | Liver | HCC | Rac protein signal transduction | 28/7958 | 42/18723 | 1.35e-03 | 7.26e-03 | 28 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:00059968 | Oral cavity | OSCC | monosaccharide metabolic process | 129/7305 | 257/18723 | 1.63e-04 | 1.13e-03 | 129 |
GO:00166018 | Oral cavity | OSCC | Rac protein signal transduction | 28/7305 | 42/18723 | 2.61e-04 | 1.67e-03 | 28 |
GO:00193188 | Oral cavity | OSCC | hexose metabolic process | 118/7305 | 237/18723 | 4.53e-04 | 2.73e-03 | 118 |
GO:00060068 | Oral cavity | OSCC | glucose metabolic process | 98/7305 | 196/18723 | 1.10e-03 | 5.63e-03 | 98 |
GO:000726514 | Prostate | Tumor | Ras protein signal transduction | 101/3246 | 337/18723 | 6.29e-09 | 2.44e-07 | 101 |
GO:005127114 | Prostate | Tumor | negative regulation of cellular component movement | 92/3246 | 367/18723 | 1.03e-04 | 9.99e-04 | 92 |
GO:000600613 | Prostate | Tumor | glucose metabolic process | 55/3246 | 196/18723 | 1.22e-04 | 1.14e-03 | 55 |
GO:200014614 | Prostate | Tumor | negative regulation of cell motility | 89/3246 | 359/18723 | 1.99e-04 | 1.74e-03 | 89 |
GO:001660112 | Prostate | Tumor | Rac protein signal transduction | 17/3246 | 42/18723 | 3.45e-04 | 2.73e-03 | 17 |
GO:004001313 | Prostate | Tumor | negative regulation of locomotion | 94/3246 | 391/18723 | 4.20e-04 | 3.21e-03 | 94 |
GO:003033613 | Prostate | Tumor | negative regulation of cell migration | 84/3246 | 344/18723 | 4.95e-04 | 3.66e-03 | 84 |
GO:00193187 | Prostate | Tumor | hexose metabolic process | 59/3246 | 237/18723 | 1.96e-03 | 1.14e-02 | 59 |
GO:00059967 | Prostate | Tumor | monosaccharide metabolic process | 62/3246 | 257/18723 | 3.38e-03 | 1.75e-02 | 62 |
GO:000726519 | Thyroid | PTC | Ras protein signal transduction | 162/5968 | 337/18723 | 3.16e-10 | 1.02e-08 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NISCH | SNV | Missense_Mutation | rs749466358 | c.743N>A | p.Arg248His | p.R248H | Q9Y2I1 | protein_coding | tolerated(0.78) | benign(0.019) | TCGA-VQ-A8P5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | SD |
NISCH | SNV | Missense_Mutation | c.4486C>T | p.Arg1496Cys | p.R1496C | Q9Y2I1 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
NISCH | SNV | Missense_Mutation | rs764100876 | c.1909G>A | p.Glu637Lys | p.E637K | Q9Y2I1 | protein_coding | tolerated(0.83) | possibly_damaging(0.456) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
NISCH | SNV | Missense_Mutation | novel | c.614N>G | p.Gln205Arg | p.Q205R | Q9Y2I1 | protein_coding | tolerated(0.16) | benign(0) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NISCH | deletion | Frame_Shift_Del | novel | c.3515delC | p.Pro1172GlnfsTer5 | p.P1172Qfs*5 | Q9Y2I1 | protein_coding | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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